Detalhe da pesquisa
1.
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
Proc Natl Acad Sci U S A
; 114(23): E4676-E4685, 2017 06 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28533375
2.
A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease.
J Biol Chem
; 289(10): 6709-6726, 2014 Mar 07.
Artigo
Inglês
| MEDLINE | ID: mdl-24407293
3.
Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay.
Neurobiol Dis
; 43(1): 248-56, 2011 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21458569
4.
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
PLoS Genet
; 3(5): e82, 2007 May 11.
Artigo
Inglês
| MEDLINE | ID: mdl-17500595
5.
Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.
Sci Rep
; 6: 25626, 2016 05 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27172999
6.
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.
Cell Chem Biol
; 23(7): 849-861, 2016 07 21.
Artigo
Inglês
| MEDLINE | ID: mdl-27427231
7.
Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration.
Neurotherapeutics
; 10(3): 400-15, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23700210
8.
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.
Nat Med
; 19(8): 1030-8, 2013 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-23852340
9.
Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons.
Neurobiol Aging
; 33(3): 621.e17-33, 2012 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-21482444
10.
TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease.
Chem Biol
; 19(2): 264-75, 2012 Feb 24.
Artigo
Inglês
| MEDLINE | ID: mdl-22365609
11.
Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1.
PLoS One
; 6(1): e16676, 2011 Jan 31.
Artigo
Inglês
| MEDLINE | ID: mdl-21304966
12.
Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions.
J Biomol Screen
; 15(7): 806-19, 2010 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-20581077
13.
Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.
Chem Biol
; 17(11): 1189-200, 2010 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-21095569
14.
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
J Cell Biol
; 187(7): 1083-99, 2009 Dec 28.
Artigo
Inglês
| MEDLINE | ID: mdl-20026656
15.
Contribution of the amino and carboxyl termini for PHA-4/FoxA function in Caenorhabditis elegans.
Dev Dyn
; 234(2): 346-54, 2005 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16127716