Detalhe da pesquisa
1.
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice.
Immunity
; 55(11): 2168-2186.e6, 2022 11 08.
Artigo
Inglês
| MEDLINE | ID: mdl-36179690
2.
Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors.
Immunity
; 55(11): 2149-2167.e9, 2022 11 08.
Artigo
Inglês
| MEDLINE | ID: mdl-36179689
3.
Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies.
Cell
; 166(6): 1459-1470.e11, 2016 Sep 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27610570
4.
Long-primed germinal centres with enduring affinity maturation and clonal migration.
Nature
; 609(7929): 998-1004, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36131022
5.
Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens.
Immunity
; 48(1): 133-146.e6, 2018 01 16.
Artigo
Inglês
| MEDLINE | ID: mdl-29287996
6.
Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies.
Immunity
; 49(2): 301-311.e5, 2018 08 21.
Artigo
Inglês
| MEDLINE | ID: mdl-30076101
7.
Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors.
Proc Natl Acad Sci U S A
; 120(1): e2217883120, 2023 01 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36574685
8.
HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.
Immunity
; 45(3): 483-496, 2016 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-27617678
9.
Author Correction: Long-primed germinal centres with enduring affinity maturation and clonal migration.
Nature
; 614(7949): E43, 2023 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-36717721
10.
B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models.
Proc Natl Acad Sci U S A
; 117(37): 22920-22931, 2020 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32873644
11.
Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.
PLoS Pathog
; 14(5): e1006986, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29746590
12.
Proof of principle for epitope-focused vaccine design.
Nature
; 507(7491): 201-6, 2014 Mar 13.
Artigo
Inglês
| MEDLINE | ID: mdl-24499818
13.
Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.
PLoS Pathog
; 13(2): e1006212, 2017 02.
Artigo
Inglês
| MEDLINE | ID: mdl-28225819
14.
Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.
Proc Natl Acad Sci U S A
; 113(44): E6849-E6858, 2016 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27791117
15.
Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
PLoS Pathog
; 12(9): e1005905, 2016 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-27627763
16.
Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
PLoS Pathog
; 12(8): e1005815, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27560183
17.
Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming.
NPJ Vaccines
; 9(1): 58, 2024 Mar 11.
Artigo
Inglês
| MEDLINE | ID: mdl-38467663
18.
High frequency of HIV precursor-target-specific B cells in sub-Saharan populations.
Cell Rep
; 42(12): 113450, 2023 12 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38019653
19.
Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming.
medRxiv
; 2023 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36993183
20.
Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer.
Cell Rep
; 38(10): 110485, 2022 03 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35263576