1.
Bioorg Med Chem Lett
; 25(18): 3992-8, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26235945
RESUMO
A series of novel 2,4-diaminopyrimidine compounds bearing bicyclic aminobenzazepine were synthesized and evaluated for their anti-ALK activities. The activities of these compounds were confirmed in both enzyme- and cell-based ALK assays. Amongst compounds synthesized, KRCA-0445 showed very promising results in pharmacokinetic study and in vivo efficacy study with H3122 xenograft mouse model.