RESUMO
In this study, the deoxidation process for off-grade titanium (Ti) sponge using magnesium (Mg) metal with a wire mesh strainer type of crucible was developed. Ti hydride (TiH2) feedstock, which was prepared by hydrogenating off-grade Ti sponge, was deoxidized using Mg in a molten magnesium chloride-potassium chloride salt at 933 K under an argon and 20% hydrogen (H2) mixed gas atmosphere. After deoxidation, the residual Mg-containing salt was separated in situ from the crucible to investigate the feasibility of minimizing salt loss during the leaching and production of pure TiH2. The results showed that the presence of residual Mg-containing salt inside the crucible strongly influenced whether a mixture of Ti and TiH2 or pure TiH2 was produced. When the salt was not sufficiently separated, a mixture of Ti and TiH2 was obtained and its oxygen (O) concentration was 0.121 mass% under certain conditions. Meanwhile, pure TiH2 was obtained by increasing the H2 gas flow rate during deoxidation. Therefore, these results demonstrate that the decrease of O concentration to below 0.180 mass% and the minimal loss of the salt are feasible.
RESUMO
PURPOSE: To retrospectively evaluate the 3-year efficacy and safety of single-agent omidenepag isopropyl in patients with normal tension glaucoma (NTG). STUDY DESIGN: Retrospective. METHODS: One hundred patients (100 eyes) who had newly been administered omidenepag isopropyl were enrolled in this study. Intraocular pressure (IOP) was compared at baseline and 6, 9, 12, 18, 24, 30, and 36 months after administration. The mean deviation values at baseline and 12, 24, and 36 months measured using the Humphrey visual field test (30-2 Swedish Interactive Threshold Algorithm standard) were compared. Adverse reactions and dropouts were assessed. RESULTS: IOP significantly decreased from 15.5±2.7 mmHg at baseline to 13.8 ±2.3 mmHg after 6 months, 13.9± 2.3 mmHg after 12 months, 13.9±2.3 mmHg after 18 months, 13.8±2.1 mmHg after 24 months, 13.9±2.0 mmHg after 30 months, and 13.6±1.7 mmHg after 36 months (P < 0.0001). There was no significant difference in the mean deviation values at baseline (-3.66±3.49 dB), 12 months (-3.41±3.80 dB), 24 months (-3.13±3.81 dB), and 36 months (-3.06±3.30 dB). Adverse reactions occurred in 11 patients (11.0%), including conjunctival hyperemia in 6 patients. Fifty-two patients (52.0%) were excluded from the analysis because they discontinued treatment either due to IOP measurement by NCT or the use of additional drugs. CONCLUSION: After the administration of omidenepag isopropyl, IOP in patients with NTG decreased within 3 years, visual fields were maintained, and safety was satisfactory. Thus, omidenepag isopropyl can be used as the first-line treatment for patients with NTG.
Assuntos
Pressão Intraocular , Glaucoma de Baixa Tensão , Soluções Oftálmicas , Campos Visuais , Humanos , Pressão Intraocular/efeitos dos fármacos , Pressão Intraocular/fisiologia , Masculino , Feminino , Estudos Retrospectivos , Glaucoma de Baixa Tensão/tratamento farmacológico , Glaucoma de Baixa Tensão/fisiopatologia , Glaucoma de Baixa Tensão/diagnóstico , Pessoa de Meia-Idade , Resultado do Tratamento , Idoso , Seguimentos , Campos Visuais/fisiologia , Tonometria Ocular , Adulto , Fatores de Tempo , Testes de Campo VisualRESUMO
An oxide scale formed on the surface of metal anodes is crucial for determining the overall quality of molten salt electrolysis (MSE), particularly for the durability of the anode materials. However, the material properties of oxide scales are yet to be revealed, particularly in ternary spinel oxide phases. Therefore, we investigate the mechanical and thermal properties of spinel oxides via first-principles calculations. The oxides are calculated using the models of normal (cubic) and inverse (orthorhombic) spinel compounds. The d-orbital exchange correlation potential of transition metal oxides is addressed using the generalized gradient approximation plus Hubbard U. The lattice constant, formation energy, cohesive energy, elastic modulus, Poisson's ratio, universal anisotropy index, hardness, minimal thermal conductivity, and thermal expansion coefficient are calculated. Based on the calculated mechanical and thermal properties of the spinel compound, the Fe-Ni-Al inert anode is expected to be the most suitable oxide scale for MSE applications among the materials investigated in our study.