Detalhe da pesquisa
1.
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
J Chem Inf Model
; 63(9): 2828-2841, 2023 05 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37060320
2.
Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.
Bioorg Med Chem Lett
; 29(17): 2503-2510, 2019 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31327531
3.
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".
J Chem Inf Model
; 64(3): 1106, 2024 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-38258980
4.
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055.
ACS Med Chem Lett
; 15(4): 524-532, 2024 Apr 11.
Artigo
Inglês
| MEDLINE | ID: mdl-38628784
5.
A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors.
ACS Med Chem Lett
; 13(3): 377-387, 2022 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35300079
6.
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
J Med Chem
; 65(22): 15208-15226, 2022 11 24.
Artigo
Inglês
| MEDLINE | ID: mdl-36346696
7.
Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.
Cancer Discov
; 12(11): 2684-2709, 2022 11 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36053276
8.
Applying the pro-drug approach to afford highly bioavailable antagonists of P2Y(14).
Bioorg Med Chem Lett
; 21(14): 4366-8, 2011 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21689930
9.
The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14.
Bioorg Med Chem Lett
; 21(10): 2836-9, 2011 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21507640
10.
Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists.
Bioorg Med Chem Lett
; 21(10): 2832-5, 2011 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21507642
11.
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
ACS Med Chem Lett
; 12(8): 1283-1287, 2021 Aug 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34413957
12.
Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists.
Bioorg Med Chem Lett
; 19(19): 5741-5, 2009 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19713110
13.
Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
J Med Chem
; 50(4): 794-806, 2007 Feb 22.
Artigo
Inglês
| MEDLINE | ID: mdl-17300164
14.
Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.
PLoS One
; 12(7): e0180965, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28700746
15.
Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice.
Cancer Res
; 63(3): 586-92, 2003 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-12566300
16.
Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.
ACS Med Chem Lett
; 7(1): 111-6, 2016 Jan 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26819676
17.
The C3a receptor antagonist SB 290157 has agonist activity.
Immunol Lett
; 100(2): 139-45, 2005 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16154494
18.
Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes.
Sci Rep
; 4: 4549, 2014 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25008545
19.
Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity.
ChemMedChem
; 8(12): 1930-40, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-24127258
20.
Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.
ACS Chem Biol
; 8(11): 2442-51, 2013 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23957438