RESUMO
Early-stage hepatocellular carcinoma (HCC) is typically clinically silent, and HCC is often advanced at first manifestation. Without treatment, the 5-year survival rate is less than 5%. The selected treatment depends on the presence of comorbidity; tumor size, location, and morphology; and the presence of metastatic disease. Complete surgical resection followed by hepatic transplantation offers the best long-term survival, but few patients are eligible for this therapy. All other therapies are palliative. Radiofrequency ablation is the preferred method for managing unresectable small HCCs that are few in number. More widespread disease is treated with percutaneous therapies such as chemoembolization and selective internal radiation therapy. Systemic administration of biologic and chemotherapeutic agents is minimally successful in slowing the growth of HCC and typically is used to control symptoms in patients with overwhelming disease. A multidisciplinary approach that includes surgery, systemic therapy, and radiation therapy and that is based on the cooperation of radiation oncologists, interventional and diagnostic radiologists, hepatologists, and pathologists may offer the best chance of a cure or at least a longer and more normal life. To participate effectively in this effort, radiologists must be familiar with staging and treatment options for HCC and with the factors that affect the choice of management method.
Assuntos
Carcinoma Hepatocelular/diagnóstico por imagem , Carcinoma Hepatocelular/terapia , Neoplasias Hepáticas/diagnóstico por imagem , Neoplasias Hepáticas/terapia , Tomografia Computadorizada por Raios X , Adulto , Idoso , Idoso de 80 Anos ou mais , Algoritmos , Carcinoma Hepatocelular/patologia , Carcinoma Hepatocelular/cirurgia , Ablação por Cateter , Quimioembolização Terapêutica , Feminino , Humanos , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/cirurgia , Masculino , Pessoa de Meia-Idade , Estadiamento de NeoplasiasRESUMO
SUMMARY: This case report details the initial radiographic findings of a patient with mixed connective-tissue disease who presented with significant hemoptysis. Several radiographic findings suggested mycetoma formation, prompting appropriate antibiotic therapy; however, the rapid resolution and subsequent reappearance of the lesion on serial images pointed toward a diagnosis of hemorrhage into a preexisting cavity. Chest radiographic and computed tomographic findings commonly described as pathognomonic for the diagnosis of mycetoma are, in fact, nonspecific and can be simulated by several other entities that result in intracavitary masses. Familiarity with these radiographic "mimickers" of mycetoma will aid in avoiding misdiagnosis and unnecessary or improper invasive interventions when the appropriate clinical history and course of disease are appreciated.
Assuntos
Hematoma/diagnóstico por imagem , Micetoma/diagnóstico por imagem , Aspergillus fumigatus/isolamento & purificação , Diagnóstico Diferencial , Feminino , Hematoma/etiologia , Humanos , Pessoa de Meia-Idade , Doença Mista do Tecido Conjuntivo/complicações , Púrpura Trombocitopênica Trombótica/complicações , Tomografia Computadorizada por Raios XRESUMO
The transition from medical student to junior doctor is well recognised to be a difficult and stressful period. To ease this transition, most UK universities have a work-shadowing period (WSP), during which students can learn practical skills needed for forthcoming employment. The aim of this study was to evaluate the WSP at Queen's University Belfast, and gain the views of both students and Foundation Programme Supervisors and Directors (FPSDs). The study utilised both qualitative (focus groups) and quantitative (questionnaires) approaches. The FPSDs completed a specific questionnaire designed for this study, while the students completed the university's internal quality assurance questionnaire. Twenty-eight of the 37 (76%) FPSDs and 106 / 196 (54%) students completed the questionnaires. Focus groups were conducted with up to 10 students in each group in both a regional centre and a district general hospital at the start and the end of the WSP as well as 8 weeks into working life. The transcripts of the focus groups were analysed and themes identified. A number of deficiencies with the current WSP were identified, including concerns about the use of log books, the timing of the attachment and relatively low levels of supervision provided by senior hospital staff members. As a result, students felt unprepared for commencing work, with particular mention given to medical emergencies, prescribing, and the emotional aspects of the job. A number of recommendations are made, including the need for more senior input to ensure better student attendance, participation and clinical interaction. Furthermore, students should be offered additional supervised responsibility for delivery of patient care and more experiential learning with respect to drug prescribing and administration. The study also suggests that more needs to be done to help ease the emotional and psychological stresses of the early FY1 period. These issues have been resolved to a large extent with the introduction of the new final year Student Assistantship module in the academic year 2010-2011.
Assuntos
Estágio Clínico , Estudantes de Medicina , Atitude do Pessoal de Saúde , Educação de Graduação em Medicina , Grupos Focais , Humanos , Irlanda do Norte , Avaliação de Programas e Projetos de Saúde , Inquéritos e QuestionáriosRESUMO
OBJECTIVE: Our objective was to review the CT appearance of liver metastases after radiofrequency ablation and to describe the imaging findings of and utility of (18)F-FDG PET and PET/CT in assessing tumor recurrence after ablation. CONCLUSION: (18)F-FDG PET and PET/CT can provide added diagnostic information compared with conventional imaging in patients after radiofrequency ablation of liver metastases and can be useful in guiding repeat ablation procedures.
Assuntos
Fluordesoxiglucose F18 , Neoplasias Hepáticas/diagnóstico por imagem , Tomografia Computadorizada de Emissão/métodos , Tomografia Computadorizada por Raios X/métodos , Ablação por Cateter , Humanos , Neoplasias Hepáticas/secundário , Neoplasias Hepáticas/cirurgiaRESUMO
Minimally invasive therapy in the urinary tract begins with renal access by means of percutaneous nephrostomy. Indications for percutaneous nephrostomy include urinary diversion, treatment of nephrolithiasis and complex urinary tract infections, ureteral intervention, and nephroscopy and ureteroscopy. Bleeding complications can be minimized by entering the kidney in a relatively avascular zone created by branching of the renal artery. The specific site of renal entry is dictated by the indication for access with consideration of the anatomic constraints. Successful percutaneous nephrostomy requires visualization of the collecting system for selection of an appropriate entry site. The definitive entry site is then selected; ideally, the entry site should be subcostal and lateral to the paraspinous musculature. Small-bore nephrostomy tracks can be created over a guide wire coiled in the renal pelvis. A large-diameter track may be necessary for percutaneous stone therapy, nephroscopy, or antegrade ureteroscopy. The most common extension of percutaneous nephrostomy is placement of a ureteral stent for treatment of obstruction. Transient hematuria occurs in virtually every patient after percutaneous nephrostomy, but severe bleeding that requires transfusion or intervention is uncommon. In patients with an obstructed urinary tract complicated by infection, extensive manipulations pose a risk of septic complications.
Assuntos
Nefrostomia Percutânea/métodos , Humanos , Intubação , Punções , Stents , Tomografia Computadorizada por Raios X , Ureter , Cateterismo Urinário/métodos , Doenças Urológicas/terapiaRESUMO
Rapid, noninvasive imaging strategies, especially multidetector spiral CT and CT angiography (CTA) as well as gadolinium-enhanced MR angiography (MRA), have facilitated early diagnosis of splanchnic venous thrombosis, a potentially lethal cause of intestinal ischemia. Single breath-hold volumetric acquisitions permit superior temporal and contrast resolution while eliminating motion artifact and suppressing respiratory misregistration. Increased spatial resolution is aided by thinner slice collimation. These cross-sectional imaging techniques are becoming a preferred noninvasive alternative to conventional selective mesenteric angiography with delayed imaging for venous evaluation and should be considered the primary diagnostic modalities for evaluating patients with high clinical suspicion of nonsurgical mesenteric ischemia.
Assuntos
Processamento de Imagem Assistida por Computador , Imageamento Tridimensional , Angiografia por Ressonância Magnética , Oclusão Vascular Mesentérica/diagnóstico , Veias Mesentéricas , Veia Porta , Portografia , Tomografia Computadorizada por Raios X , Trombose Venosa/diagnóstico , Humanos , Intestinos/irrigação sanguínea , Isquemia/diagnóstico , Veias Mesentéricas/patologia , Veia Porta/patologia , Valor Preditivo dos TestesRESUMO
The recent increase in usage of ureteral stents in the management of a variety of urinary tract disease processes mandates familiarity with these devices, their consequences, and their potential complications, which at times can be devastating. Radiology plays an important role in the routine monitoring of stents and in the evaluation of these consequences and complications. It may also offer solutions for their correction. Stents should be monitored while in place, promptly removed when no longer needed, and changed periodically if chronically indwelling. Risk factors for complications should be minimized with high fluid intake, timely evaluation of clinical complaints, and aggressive treatment of documented infection. Certain patients may not be best served by indwelling stent placement, and urinary diversion by means of other mechanisms may be indicated. The implanting physician is responsible for informing the patient of the requirements, consequences, and complications associated with stent placement. Failure to do so has obvious management and potential medicolegal implications.
Assuntos
Stents/efeitos adversos , Obstrução Ureteral/cirurgia , Cateterismo/efeitos adversos , Desenho de Equipamento , Falha de Equipamento , Humanos , Complicações Pós-Operatórias , Radiografia IntervencionistaRESUMO
BACKGROUND: The purpose of this study was to review the trend of using chest computed tomography (CT) and aortography in evaluating patients with blunt thoracic trauma. METHODS: A total of 85 patients who had blunt aortic injury diagnosed by chest CT, aortography, or both were included in this study. RESULTS: Aortography was the dominant modality before 1998, and the use of chest CT has increased to 50% of patients with aortic injuries as of 2001. Isolated aortic, branch vessel, or combined injuries were found in 71 (84%), 11 (13%), and 3 (4%) patients, respectively. All 14 patients with branch vessel injuries were diagnosed by aortography. Ninety-eight percent of patients with aortography were true-positives, and 20% of patients with chest CT had indirect signs of aortic injury. CONCLUSION: Our institution has increased the use of chest CT to evaluate blunt thoracic trauma. Patients with indirect signs of aortic injuries shown on chest CT require further evaluation. In our experience, angiography remains the optimal diagnostic modality for evaluating aortic branch vessel injuries.
Assuntos
Aorta Torácica/lesões , Ferimentos não Penetrantes/diagnóstico por imagem , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Aorta Torácica/diagnóstico por imagem , Aortografia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X , Centros de TraumatologiaRESUMO
Mesenteric venous thrombosis is an uncommon but potentially lethal cause of bowel ischemia. Several imaging methods are available for diagnosis, each of which has advantages and disadvantages. Doppler ultrasonography allows direct evaluation of the mesenteric and portal veins, provides semiquantitative flow information, and allows Doppler waveform analysis of the visceral vessels; however, it is operator dependent and is often limited by overlying bowel gas. Conventional contrast material-enhanced computed tomography (CT) allows sensitive detection of venous thrombosis within the central large vessels of the portomesenteric circulation and any associated secondary findings; however, it is limited by respiratory misregistration, motion artifact, and substantially decreased longitudinal spatial resolution. Helical CT and CT angiography, especially when performed with multi-detector row scanners, and magnetic resonance (MR) imaging, particularly gadolinium-enhanced MR angiography, enable volumetric acquisitions in a single breath hold, eliminating motion artifact and suppressing respiratory misregistration. Helical CT angiography and three-dimensional gadolinium-enhanced MR angiography should be considered the primary diagnostic modalities for patients with a high clinical suspicion of mesenteric ischemia. Conventional angiography is reserved for equivocal cases at noninvasive imaging and is also used in conjunction with transcatheter therapeutic techniques in management of symptomatic portal and mesenteric venous thrombosis.
Assuntos
Oclusão Vascular Mesentérica/diagnóstico , Trombose Venosa/diagnóstico , Adulto , Idoso , Feminino , Humanos , Angiografia por Ressonância Magnética , Imageamento por Ressonância Magnética , Masculino , Veias Mesentéricas , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X , Ultrassonografia DopplerRESUMO
PURPOSE: To assess, by using computer simulation, the effect of the use of reduced computed tomographic (CT) tube current on reader evaluation of structures and lung findings on images obtained at clinically indicated chest CT examinations. MATERIALS AND METHODS: The noise level in the raw scan data of 150 clinically indicated conventional tube current (200-320-mA) chest CT examinations was modified to simulate tube current reduction to 100 and to 40 mA. A total of 450 image sets were thus available. Four radiologists blinded to the tube current used assessed the image sets in random order for 14 structures and lung findings and ranked subjective image quality by using a five-point scale (1 = nondiagnostic, 2 = inferior, 3 = adequate, 4 = good, 5 = excellent). After a 3-week interval, the 150 conventional tube current image sets were rescored so that intraobserver agreement could be assessed. The McNemar statistic was used to determine whether there were more scoring disagreements between interpretations of the conventional and those of the reduced tube current scans or between the two interpretations of the conventional tube current scans. RESULTS: When overall agreement for 14 structures and lung findings was pooled over four observers, significantly more disagreements (P <.05) were seen when scores were compared between conventional and reduced tube current scans than when scores were compared between repeated interpretations of the conventional tube current scans. There was a significant decrease (P <.05) in the subjective image quality of reduced tube current scans compared with the subjective image quality of conventional tube current scans. CONCLUSION: These data indicate that reduced tube current does affect reader evaluation of structures and lung findings and reduces a reader's subjective assessment of image quality.