Detalhe da pesquisa
1.
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
Proc Natl Acad Sci U S A
; 114(23): E4676-E4685, 2017 06 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28533375
2.
Sirtuins in Alzheimer's Disease: SIRT2-Related GenoPhenotypes and Implications for PharmacoEpiGenetics.
Int J Mol Sci
; 20(5)2019 Mar 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30871086
3.
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.
Hum Mol Genet
; 20(20): 3986-96, 2011 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21791548
4.
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.
Proc Natl Acad Sci U S A
; 107(17): 7927-32, 2010 Apr 27.
Artigo
Inglês
| MEDLINE | ID: mdl-20378838
5.
3-(N-arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2).
Bioorg Med Chem Lett
; 22(8): 2789-93, 2012 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22446090
6.
Drug targeting of dysregulated transcription in Huntington's disease.
Prog Neurobiol
; 83(4): 249-59, 2007 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-17379386
7.
The role of Nrf2 signaling in counteracting neurodegenerative diseases.
FEBS J
; 285(19): 3576-3590, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29323772
8.
Discovery of a novel small-molecule targeting selective clearance of mutant huntingtin fragments.
J Biomol Screen
; 12(3): 351-60, 2007 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-17379859
9.
Discovery of bioactive small-molecule inhibitor of poly adp-ribose polymerase: implications for energy-deficient cells.
Chem Biol
; 13(7): 765-70, 2006 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-16873024
10.
Cellular pathways leading to neuronal dysfunction and degeneration.
Drug News Perspect
; 20(8): 501-9, 2007 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-18080037
11.
Two approaches to drug discovery in SOD1-mediated ALS.
J Biomol Screen
; 11(7): 729-35, 2006 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16928982
12.
LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease.
J Huntingtons Dis
; 5(4): 347-355, 2016 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27983565
13.
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.
Cell Chem Biol
; 23(7): 849-861, 2016 07 21.
Artigo
Inglês
| MEDLINE | ID: mdl-27427231
14.
Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors.
ACS Med Chem Lett
; 6(5): 607-11, 2015 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26005542
15.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
PLoS One
; 10(1): e0116919, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25608039
16.
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
Eur J Med Chem
; 76: 414-26, 2014 Apr 09.
Artigo
Inglês
| MEDLINE | ID: mdl-24602787
17.
Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases.
Neurodegener Dis Manag
; 7(2): 97-100, 2017 04.
Artigo
Inglês
| MEDLINE | ID: mdl-28534719
18.
SIRT2 as a Therapeutic Target for Age-Related Disorders.
Front Pharmacol
; 3: 82, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22563317
19.
Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia.
Front Pharmacol
; 3: 42, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22416232
20.
The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
Cell Rep
; 2(6): 1492-7, 2012 Dec 27.
Artigo
Inglês
| MEDLINE | ID: mdl-23200855