[Changes in vaginal microbiocenosis in patients with chronic pelvic inflammatory diseases following antibiotic therapy].

The species composition of the vaginal microorganisms in healthy women and in patients with chronic pelvic inflammatory diseases before and after treatment in a gynecological hospital was studied. The study revealed that antibiotic therapy did not lead to complete clinical convalescence. During bacteriological investigation of patients changes in vaginal microbiocenosis, manifested by a decreased number of microbial species, an increased proportion of Escherichia coli, the occurrence of Staphylococcus aureus, a decreased number of Lactobacillus ssp., were observed. Antibiotic therapy aggravated the dysbiotic microbial picture of the vagina.

[An experimental study of autovaccines prepared with different preservatives]. / Eksperimental'noe izuchenie autovaktsin, prigotovlennykh na razlichnykh konservantakh.

The comparative study of the immunological potency of staphylococcal vaccines prepared on the basis of different preservatives the mixture of formaldehyde, glutaraldehyde and 0.5% novocaine solution in combination with Gorgiev's bactericidal fluid) was made in experiments on mice. The vaccine was prepared from three staphylococcal strains isolated from chronic tonsillitis patients. The optimum low concentrations of formaldehyde (0.025%) and glutaraldehyde (0.0125%), producing bactericidal effect on staphylococci, have been established. The vaccine prepared with the use of Gorgiev's bactericidal fluid and 0.5% novocaine solution was found to have the highest immunogenic potency. The vaccine prepared on the basis of the aldehyde mixture exhibited the lowest potency.

[Experimental reactivity and antigenic activity of the bacterial-fungal antigen complexes]. / Reaktogennost' i antigennaia aktivnost' bakterial'no-gribkovogo kompleksa antigenov v éksperimente.

The immunogenic and reactogenic properties of monovaccines prepared from Staphylococcus aureus, S. epidermidis and Candida albicans, as well as those of a associated polyvaccine prepared from these infective agents, were experimentally studied on rabbits. The monovaccines and the associated bacterial-fungal vaccines were found to be safe and faintly reactogenic; in the blood serum of vaccinated rabbits a growth in the titer of agglutinins and its preservation at a high level for 4 months were noted.

[Integral mathematical parameters of a gemogram as criteria for evaluation of severity of chronic adnexitis and of treatment efficacy in conservative therapy]. / Integral'no-matematicheskie pokazateli gemogrammy kak kriterii otsenki tiazhesti techeniia khronicheskogo adneksita i éffektivnosti terapii pri traditsionnom metode lecheniia.

A number of hematological indices of the peripheral blood in patients with chronic adnexitis were mathematically calculated to evaluate a disease severity and an effect of recovery by using the traditional therapy method. It was established that the integral-and-mathematical indices of hemogram reflect clinical disease acuteness while receiving patients to hospital. A comprehensive evaluation of hematological indices makes it possible to determine the severity of inflammatory process in women, to detect the efficacy of a conducted therapy and to choose a strategy for further metabolic correction to ensure a maximum treatment effect.