[TOTAL KNEE REPLACEMENT WITH PATIENT SPECIFIC INSTRUMENT IN PATIENTS WITH SECONDARY OSTEOARTHRITIS].

INTRODUCTION: Total knee arthroplasty is the most prevalent operation with a high success rate in the treatment of primary osteoarthritis. However, patients with complex secondary osteoarthritis remained marginalized to the surgical response or otherwise exposed to high risk conventional surgery. Early decades of life, surgical history, technical complexity, high surgical morbidity, variability of pathology and anatomy and poor clinical outcome are a few of the reasons. The assimilation of modern technology shifted the concept and practice in the field of arthroplasty, opening a window of treatment opportunities for patients with secondary osteoarthritis with patient specific implants (PSI). AIMS: Evaluate safety, efficacy and applicability limitations of PSI as an alternative to conventional total knee arthroplasty in complex clinical settings. Furthermore, the study aimed to conduct assessments of clinical outcome and technical aspects. METHODS: This was a prospective cohort clinical study, based on Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire pre and post-operative. The study was conducted through a structured analysis of parameters characterizing patients who are candidates for treatment with PSI, highlighting technical points. RESULTS: A curve of 31point improvement (p=0.021) in the WOMAC score at minimum 12 month follow up was observed. There was demonstration of the specific elements required for balancing lower limb axis deformity and previous metal retaining situations. CONCLUSIONS: PSI technology offers a reduction of surgical complexity, morbidity and complication potential with significant improvement in clinical outcome, in patients with secondary osteoarthritis associated with extra articular deformities, presence of hardware, and in musculoskeletal rare diseases. DISCUSSION: A first time presentation of focused, isolated and specified characteristics of a patient population with secondary osteoarthritis where PSI establishes a step forward in the treatment and outcome of patients with complex clinical presentation.

[111 INDIUM LABELED LEUKOCYTE SCINTIGRAPHY IS A LOW SENSITIVITY TEST FOR DIAGNOSING PROSTHETIC JOINT INFECTION IN EQUIVOCAL CASES].

INTRODUCTION: Nuclear medicine techniques are suggested to be used in equivocal cases only. Nuclear medicine procedures, specifically labeled leucocytes however, are widely used in the diagnosis of joint infection across Europe. The aim of our study was to determine if Indium 111 labeled leukocyte scintigraphy has a role in the diagnosis of infected prosthetic joints. METHODS: In this retrospective cohort study, the records of a total of 146 prosthetic hip or knee revision surgeries, in 116 patients, performed in our Institute between the years 2013-2016 were reviewed. A total of 34 patients with labeled leukocyte scans were analyzed. Ten patients had more than one scan (two to four times). The scintigraphy result reports were correlated with the outcome with respect to intra-/post-operative diagnosis of prosthetic joint infection. RESULTS: The findings of 42 of 44 scintigraphy tests were negative. One study in a patient who had three prior negative labeled white blood cells (WBC) scintigraphies was equivocal. One study was positive, but a later test in the same patient was negative. Of these 34 patients, nine were demonstrated intra- or post operatively as positive for infected prosthetic joint, including the two positive cases above. The remaining 25 patients went through revision surgery with no evidence of infection; 30 of 38 bone scans were positive. Of these 30 patients, seven were demonstrated intra- or post-operatively as positive for infected prosthetic joint. CONCLUSIONS: In our study population indium labeled leukocyte scintigraphy was found to be a non-sensitive test for the diagnosis of a prosthetic joint infection and had a poor negative predictive value. It is expected that following the guidelines more strictly and choosing the appropriate modality for assessing prosthetic joint infection will improve the diagnostic accuracy of these techniques.

Patellofemoral Arthroplasty for Irreducible Chronic Bilateral Patella Dislocation-A Case Report.

Introduction: Patellofemoral joint arthroplasty (PFJA) is mainly used to treat older patients suffering from osteoarthritis. However, this case report sheds light on the implications of this treatment for young patients suffering from patellar maltracking and secondary patellofemoral osteoarthritis (PFOA). Case Report: A female patient in her late 3rd decade of life presented with long-standing bilateral knee pain and significant functional impairment, including difficulty walking and stair climbing. She also expressed concern as a young female about her walking esthetics. Medical records indicated she underwent bilateral MPFL reconstruction in both knees simultaneously when she was 8 years old. Imaging studies revealed a bilateral complete patellar dislocation accompanied by bilateral patellofemoral joint osteoarthritis worse in the right knee. Various conservative treatment attempts were made with no or minimal relief. Consequently, bilateral PFJA was conducted, resulting in an overall transformational improvement in life quality at 39 months of follow-up on the right knee and 7 months of follow-up on the left knee. Conclusion: PFJA is extremely beneficial for treating young patients suffering from patellar maltracking and patellofemoral arthritis. This is an original case report of interest to orthopedic surgery. Not only does PFJA treat osteoarthritis, but it also improves patellar tracking and may even decrease the progression of tibiofemoral osteoarthritis.

Distal femur segmental gap reconstruction using ipsilateral amputated tibia in trauma setting - A case report.

Background: A 32 year old patient who sustained an ipsilateral Gustilo Anderson 3C open fractures of the distal femur and tibia, following an MVA (Motor Vehicle Accident). The femoral shaft fracture had a 6 cm gap, which was spanned with a tibial diaphyseal autograft harvested from the amputated ipsilateral leg and stabilized with a retrograde intramedullary nail, thus enabling preservation of the knee joint and a functional weight bearing below knee prosthesis. Conclusion: Distal femur segmental gap reconstruction using ipsilateral amputated tibia in trauma setting was shown to be a feasible surgical technique.

Surgical stabilisation in equivocal pelvic ring injuries - Into the grey zone.

Pelvic ring injuries comprise a spectrum of bony, ligamentous and muscular injuries, described by several common classification systems. However, the majority of injuries lie in areas of intermediate severity, where complexity and variable nature make it extremely hard to define in detail. This fact and associated injuries make it extremely difficult to conduct randomised control trials, with purpose to direct treatment guidelines. Thus, special interest and expertise are required by pelvic trauma surgeons, while surgical indications and fixation methods rely on their experience, at least in part. Namely, a significant grey zone of indication exists. As fixation methods evolve, specifically percutaneous fixation using osseous fixation pathways, some injuries in which morbidity bound with surgical fixation was considered too high relative to its benefits, may be considered eligible for surgical treatment nowadays. Moreover, due to significant progress in the treatment of the acute polytrauma casualties, the survival rate increased over the years, emphasizing the effect of long-term morbidity and functional outcome of pelvic ring injuries. The purpose of this manuscript is to describe the equivocal areas of controversies, hence "the grey zone", and to provide the readership with up-to-date published data. We aimed to collect and detail clinical and radiological clues in the diagnosis of intermediate unstable anterior-posterior compression and lateral compression injuries, and for the selection of treatment methods and sequence. Recent publications have provided some insights into specific injury features that are correlated with increased chance of instability, pain and delay in ambulation. Specific focus is given to the utility of examination under anaesthesia in selected cases. Other publications surveyed the shared experience of pelvic trauma surgeons as for the classification, indication and treatment sequence of pelvic ring injuries. Although the data hasn't matured yet to a comprehensive treatment algorithm, it may serve clinicians well when making treatment decisions in the grey zone of pelvic ring injuries, and serve as a basis for future prospective studies.

Surgical Correction of Non-traumatic Patella Maltracking. Midterm Clinical Follow-up.

BACKGROUND: Patellar instability comprises a group of pathologies that allow the patella to move out of its trajectory within the trochlear groove during walking. Symptomatic patients who need surgery commonly undergo soft tissue procedures such as medial patellofemoral ligament repair to strengthen the ligaments that hold the patella in place. However, soft-tissue repairs may be insufficient in patients suffering from patellar maltracking, which is characterized by an unbalanced gliding of the patella within its route. In these patients, a different approach is advised. We aim to provide the mid-term clinical outcomes of the Fulkerson distal realignment operation in selected patients with non-traumatic patellar maltracking. METHODS: The clinical outcomes of the Fulkerson distal realignment operation performed in 22 knees of 21 patients were evaluated by a self-administered subjective International Knee Documentation Committee (IKDC) score and the Tegner-Lysholm knee scoring scale. RESULTS: Before surgery, the median IKDC score was 52, and the median Tegner-Lysholm score was 56. Following surgery (mean follow-up 48 months, range 24-156), the median IKDC and the Tegner-Lysholm scores were 67 and 88, respectively. The improvement was statistically significant (P=0.001 and P=0.002 for IKDC and Tegner-Lysholm scores, respectively). Associated procedures included patella microfracture due to grade III-IV cartilage lesion (International Cartilage Repair Society grading system) in four patients, retinacular releases in three patients, medial capsular augmentations in two patients, and medial patellofemoral ligament reconstruction in two patients. One patient with Ehlers-Danlos disease required excessive medialization of the tibial tuberosity. Surgery-related complications occurred in three patients. DISCUSSION: Surgical correction of patellar maltracking with Fulkerson distal realignment combined with associated procedures in individual patients was associated with an increase in subjective and functional clinical scores at medium-term follow-up. Particular attention should address pathologies associated with patellar maltracking and managed accordingly. LEVEL OF EVIDENCE: 4c (case series).

Orthopedic screws insertion simulation with immediate feedback enhances surgical skill.

BACKGROUND: Screw insertion to bones is a fundamental skill in orthopedic, spine and cranio-maxillofacial surgery. Applying the correct tightening torque is critical when compressing and fixating bone fragments. Overtightening yields in plastic deformation of the bone and destruction of the screw-bone interface, damaging the construct's stability. The surgeon is required to achieve sufficient hold and compression without stripping the bone. Several studies have investigated these skills, demonstrating much potential to enhance the future surgeons' capabilities. This study presents a novel training module, combining direct tightening followed by deliberate striping with immediate feedback suggested to enhance the surgeon's tactile perception and improve skill. METHODS: A prospective single-blinded cohort study was run. Twenty surgeons from various disciplines, excluding orthopedic and maxillo-facial surgeons, were trained using an orthopedic screws insertion model, comprised of synthetic bones. Training sessions considered inserting 40 screws into normal and osteoporotic bone models, experiencing deliberate stripping of the screws and feedback for their performance in three different sessions. FINDINGS: Success rate increased between sessions - by 24% to 48% in normal bone, and by 37% to 52% in osteoporotic bone. Stripping rate decreased between sessions - by 37.5% to 18.5% in normal bone, and by 29% to 14% in osteoporotic bone. Average ratio between tightening torque and maximum possible torque before bone stripping improved gradually and consistently from 67.3% to 81.6% in normal bone (p < 0.001), and slightly from 76.4% to 77.5% in osteoporotic bone (p = 0.026). INTERPRETATION: Immediate feedback with deliberate stripping and external feedback using a digital torque measuring screwdriver may improve cortical screw insertion technique in the surgeons' community.

Interobserver and intraobserver agreement for Letournel acetabular fracture classification system using 3-dimensional printed solid models.

BACKGROUND: Acetabular fractures pose diagnostic and surgical challenges. They are classified using the Judet-Letournel system, which is based solely on X-ray. However, computed tomography (CT) imaging is now more widely utilized in diagnosing these injuries. The emergence of 3-dimensional (3-D) printing technology in varying orthopedic fields has provided surgeons a solid model that improves their spatial understanding of complex fractures and ability to plan pre-operatively. AIM: To evaluate the reliability of the Judet-Letournel classification system of acetabular fractures, when using either CT imaging or 3-D printed models. METHODS: Seven patients with acetabular fractures underwent pelvic CT imaging, which was then used to create solid, 3-D printed models. Eighteen orthopaedic trauma surgeons responded to questionnaires regarding fracture classification and preferred surgical approach. The same questionnaire was completed using only CT imaging, and two weeks later, using only 3-D printed models. The inter- and intra-observer agreement rates were then analyzed. RESULTS: Inter-observer agreement rates based on CT imaging or 3-D printed models were moderate for fracture classification: κ = 0.44, κ = 0.55, respectively (P < 0.001) and fair for preferred surgical approach: κ = 0.34, κ = 0.29, respectively (P < 0.005). Intra-observer agreement rates for fracture classification and preferred surgical approach comparing CT imaging or 3-D printed models were moderate: κ = 0.48, κ = 0.41, respectively. No significant difference in intra-observer agreement was detected when comparing orthopedic pelvic specialists to general orthopedic traumatologists. CONCLUSION: The Judet-Letournel classification demonstrated only moderate rates of agreement. The use of 3-D printed models increased the inter-observer agreement rates with respect to fracture classification, but decreased it with respect to the preferred surgical approach. This study highlights the role of 3-D printed models in acetabular fractures by improving spatial understanding of these complex injuries, thus providing more reliable fracture diagnoses and alternative viewpoints for pre-operative planning.

Is initial interfragmentary compression made to last? An ovine bone in vitro study.

Interfragmentary compression, a major principle of fracture treatment, is clinically not quantified and might be lost quickly even without functional loads. We designed an experimental study hypothesizing that (1) compression can be controlled using either lag screw or compression plate, and expecting similar initial compression, (2) loss of interfragmentary compression through relaxation within one hour is reduced with neutralization locking plate next to lag screw compared to compression plate. Twelve ovine femora (N=6) and humeri (N=6) were assigned into groups: Group 1 received a 45° oblique osteotomy at mid-diaphysis and was fixated using a 3.5 mm interfragmentary lag screw and locking compression plate (3.5 mm LCP, DePuy Synthes) as neutralization plate. Group 2 received a transverse osteotomy and was fixated with dynamic compression using compression plate (LCP). Interfragmentary pressure and relative bone fragment displacements were recorded over one hour. Median loss of compression over one hour time (relaxation) were 0.52% in Group 1, and 0.17% in Group 2 (p>0.05). Median rotational displacements amounted to 0.46° for Group 1, and 0.31° for Group 2, and axial displacement to a median of -20 µm in Group 1 and 25 µm in Group 2. Ovine bone interfragmentary stress relaxation maintains compression over the first hour for lag screw with neutralization plate for an oblique fracture line or compression plate for a transverse fracture line. Measured compression forces around 100 N could be overcome by physiological tension loading in bending or torsion, necessitating for instance tension band plating, additional lag screws or absolutive stability.

Knee arthroplasty with hardware removal: complication cascade. Is it preventable?

An elderly woman underwent hardware removal and total joint replacement (TJR) of her right knee. Ipsilateral total tip replacement was performed 7 years earlier, and 12 months later, a supracondylar fracture of the index femur was successfully treated by open reduction internal fixation (ORIF) of the distal femur with a locking compression plate condylar plate. Hardware removal attempt, prior to the arthroplasty, resulted in fracture of the distal femur. Total knee replacement (TKR) was commenced with temporary reduction and final stabilisation of the femur fracture with a condylar plate. Postoperatively, non-union of the femur fracture developed twice with fatigue failure of the plate fixation device in both instances. Refixation of the femur was performed on both occasions and additional bone healing augmentation measures were performed for each subsequent surgery. Femur union was achieved fourteen months after the last surgery.

Preoperative Evaluation of Intramedullary Tibial Nail Measurements-A Review of the Literature and a New Technique Using Contralateral Radiographs and Digital Planning.

INTRODUCTION: An accurate selection of tibial nail and screws measurements is paramount in purpose to achieve proper tibial fracture reduction and fixation, avoid irritation of the soft-tissue envelope, and enable extraction of the nail in the future, if needed. To this date, many methods were suggested to determine the length and diameter of an intramedullary tibial nail, preoperatively and intraoperatively. Each method has its disadvantages, and most are lacking in accuracy. Digital aids are currently available for preoperative planning for many types of surgeries. METHODS: Retrospectively, 27 patients operated for diaphysial tibial fracture intramedullary nailing were selected. The contralateral leg was imaged using AP and lateral radiograph views. Six orthopaedic trauma surgeons used the TraumaCad program (Voyant Health) to plan the appropriate nail and distal locking screws measurements, while blinded from the actual hardware used in the operation. Later, they also conducted quality review regarding the operation carried out and suggested correction in measurements of the hardware. Intra-observer and inter-observer reliability was calculated. RESULTS: The inter-correlation coefficient for the planned nails was 0.97 and 0.84 (P < 0.001) in AP view for length and diameter, respectively, and similarly 0.98 and 0.86 (P < 0.001) in lateral view. The interclass correlation coefficient (ICC) for the locking screws length was 0.7 (P < 0.02) and 0.82 (P < 0.01) for the proximal and distal medio-lateral screws, respectively, and 0.9 (P < 0.001). The ICC between AP and lateral views was 0.98 for length and 0.96 for diameter (P < 0.001). The scores and corrections given by the examiners to the actual selected nail were ICC of 0.98 and 0.96 (P < 0.001) for length and diameter, respectively. The examiners suggested they would correct, post-factum, the length of the nail in average 28% and the diameter in average 30%. The average observer resulted in ICC of 0.94 and 0.91 (P < 0.001) in length and only 0.77 and 0.67 (P < 0.001) in diameter (AP and lateral views, respectively) when comparing the actual nail used and the post-factum plan. CONCLUSION: Preoperative planning of tibial fractures' nailing using imaging of the contralateral leg and a digital graphic planning program is an accurate and reliable method. It may serve to reduce errors, surgical time, and radiation dose in the operating room. This method could also be applied for surgical debriefing.

Rhabdomyolysis. The role of diagnostic and prognostic factors.

Rhabdomyolysis, literally meaning the breakdown of muscle tissue, is a common syndrome with many causes, acquired ones such as exertion, trauma, infections, temperature extremes, drugs, toxins, electrolyte and endocrine abnormalities, and congenital ones such as myopathies and connective tissue disorders. All results in a common pathophysiologic pathway which ends with the dispersing of muscle tissue content into the circulation. Rhabdomyolysis has characteristic clinical, laboratory and radiologic features, but does require a high index of suspicion so that the diagnosis would not be missed. The sensitivity and specificity of the various characteristics, as well as clinical guidelines, are discussed in this paper. The syndrome may present with several complications, e.g. arrhythmias, electrolyte abnormalities, acute renal injury, acidosis, volume depletion, compartment syndrome and disseminated intravascular coagulation. The prognosis is highly variable and depends on the underlying etiologies and complications, but is in general considered as good. The milestone of treatment is vigorous fluid resuscitation. Treatment options, in practice and in research, are discussed in the following pages.