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1.
Adv Health Sci Educ Theory Pract ; 23(1): 159-186, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28667549

RESUMO

Feedback in medical education is complicated by the multiple contexts within which learning occurs. However, feedback research in medical education has typically focused on information provided by tutors to students with limited exploration of the influence of context. This research seeks to address this gap by exploring the influence of multiple contexts upon feedback processes. Employing video-ethnography methodology we explored feedback in two common contexts for medical student learning: the simulated clinical environment and the medical workplace. Learning and teaching sessions were filmed in each of these contexts, capturing diverse feedback processes. Data were analysed for key themes using a Framework Analysis approach and similarities and differences between the two contexts identified. In total 239 distinct feedback episodes across 28 different teaching and learning sessions were captured, with feedback processes relating to the patient, practice, educational and institutional contexts observed. In this paper, we concentrate on key similarities and differences in feedback processes between the two contexts with respect to six themes: feedback interlocutors, interlocutor positioning, feedback types, feedback foci, feedback styles and feedback milieu. We argue that feedback is inextricably linked to the multiple contexts in which feedback is enacted. It is only by exploring these contextual influences that feedback can be understood more fully. With such understanding we should be better placed to develop interventions capable of improving the long elusive experience of successful feedback.


Assuntos
Educação de Graduação em Medicina/métodos , Feedback Formativo , Estudantes de Medicina/psicologia , Gravação em Vídeo , Adolescente , Adulto , Antropologia Cultural , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Faculdades de Medicina , Adulto Jovem
2.
Med Teach ; 37(6): 585-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25155281

RESUMO

BACKGROUND: There are a number of approaches to teaching high-risk clinical skills, such as a large bore chest drain insertion, although effectiveness is limited and realism is only achieved at great expense. Summary of work: In response to a training needs' analysis of practitioners in remote and rural areas in Scotland, training in chest drains was identified as an urgent priority need. Subsequently, the Clinical Skills Managed Educational Network (CSMEN) developed an evidence-based multi-professional clinical skills pack. This e-learning resource encompasses all aspects of chest drain management, both pre and in-hospital. The pack and an interactive workshop is used to deliver 'blended' chest drain training on a mobile clinical skills unit. Evaluation confirms that the chest drain training is a valuable resource and has been widely used to deliver skills training in remote and rural areas. Feedback from all professional groups is positive. CONCLUSIONS: Developing shared national resources, with standardised workshops taught in local contexts via a mobile skills unit is one approach to the challenges associated with delivering high-risk clinical skills education.


Assuntos
Cateterismo/métodos , Tubos Torácicos , Serviços de Saúde Rural , Treinamento por Simulação/métodos , Competência Clínica , Medicina Baseada em Evidências , Humanos , Avaliação de Programas e Projetos de Saúde , Escócia
3.
Qual Prim Care ; 22(1): 43-51, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24589150

RESUMO

BACKGROUND: The rising prevalence of obesity and diabetes in Kuwait represents a significant challenge for the country's healthcare system. Diabetes care in Scotland has improved by adopting a system of managed clinical networks supported by a national informatics platform. In 2010, a Kuwait-Dundee collaboration was established with a view to transforming diabetes care in Kuwait. This paper describes the significant progress that has been made to date. METHODS: The Kuwait-Scotland eHealth Innovation Network (KSeHIN) is a partnership among health, education, industry and government. KSeHIN aims to deliver a package of clinical service development, education (including a formal postgraduate programme and continuing professional development) and research underpinned by a comprehensive informatics system. RESULTS: The informatics system includes a disease registry for children and adults with diabetes. At the patient level, the system provides an overview of clinical and operational data. At the population level, users view key performance indicators based on national standards of diabetes care established by KSeHIN. The national childhood registry (CODeR) accumulates approximately 300 children a year. The adult registry (KHN), implemented in four primary healthcare centres in 2013, has approximately 4000 registered patients, most of whom are not yet meeting national clinical targets. A credit-bearing postgraduate educational programme provides module-based teaching and workplace-based projects. In addition, a new clinical skills centre provides simulator-based training. Over 150 masters students from throughout Kuwait are enrolled and over 400 work-based projects have been completed to date. CONCLUSION: KSeHIN represents a successful collaboration between multiple stakeholders working across traditional boundaries. It is targeting patient outcomes, system performance and professional development to provide a sustainable transformation in the quality of diabetes healthcare for the growing population of Kuwaitis with diabetes in Kuwait.


Assuntos
Diabetes Mellitus/epidemiologia , Pessoal de Saúde/educação , Informática Médica/organização & administração , Obesidade/epidemiologia , Educação de Pacientes como Assunto/métodos , Garantia da Qualidade dos Cuidados de Saúde/organização & administração , Adulto , Criança , Diabetes Mellitus/prevenção & controle , Diabetes Mellitus/terapia , Educação de Pós-Graduação , Coalizão em Cuidados de Saúde/organização & administração , Coalizão em Cuidados de Saúde/normas , Humanos , Relações Interinstitucionais , Cooperação Internacional , Kuweit/epidemiologia , Informática Médica/normas , Informática Médica/tendências , Obesidade/complicações , Obesidade/terapia , Prevalência , Garantia da Qualidade dos Cuidados de Saúde/métodos , Garantia da Qualidade dos Cuidados de Saúde/normas , Melhoria de Qualidade/organização & administração , Melhoria de Qualidade/normas , Sistema de Registros , Escócia/epidemiologia
4.
World J Surg ; 37(5): 957-64, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23404485

RESUMO

BACKGROUND: There is growing evidence that training on virtual reality simulators leads to improved performance in the animate and human operating room. However, they are expensive, have a limited availability, and involve complex systems. Portable simulators are significantly cheaper, more user-friendly, and are flexible systems that are more suited to a surgical trainee's busy schedule. The use of portable surgical simulators to train skills and reduce errors has never been evaluated in prospective, randomized clinical settings. The objective of this study was to determine if training on the portable Integrated Laparoscopic Simulator leads to improved performance of core laparoscopic skills. METHODS: Core laparoscopic skills were identified by five experienced laparoscopic surgeons and modeled into two exercises and three basic tasks. Twenty surgically naive medical students had baseline laparoscopic skills assessed on a fixed simulator. Participants were randomized to either 14 h training on a portable laparoscopic simulator over a 3 week period, or control with no training. At 3 weeks two expert laparoscopic surgeons blinded to the allocation of participants assessed their pre- and post-intervention performances recorded on a CD-ROM. The outcome measures included time to complete and global rating scores of clipping and dissection tasks. RESULTS: No differences were observed in baseline skills level between the two groups. The intervention group had better quality of scissors dissection (p = 0.0038) and improved clipping skills (p = 0.0051), and they took less time to accomplish the tasks (p = 0.0099) in comparison to control. CONCLUSIONS: Training on the portable Integrated Laparoscopic Simulator significantly improved core laparoscopic skills in medical students with no prior experience.


Assuntos
Competência Clínica , Simulação por Computador , Laparoscopia/educação , Modelos Educacionais , Adulto , Técnica Delphi , Feminino , Humanos , Masculino , Reino Unido , Interface Usuário-Computador
5.
Alcohol Alcohol ; 47(1): 75-8, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22085525

RESUMO

AIMS: To assess perceptions on alcohol misuse and addiction among medical students prior to in-depth training in order to determine areas of the curriculum that need to be reshaped or focused on. METHODS: A questionnaire assessment of first- and second-year medical students' perceptions of alcohol misuse. RESULTS: Students had some misconceptions about current alcohol misuse rates, including a perception that addiction is common among health professionals, that the under-25s had the fastest increasing rate of alcohol addiction and that British women had a more rapidly increasing rate of alcohol addiction than British men. CONCLUSION: Encouragingly, students overwhelmingly felt that alcohol addiction was something to which they could make a difference. It highlights that early education about alcohol misuse is important in terms of teaching students how to recognize hazardous and harmful drinkers and how to manage them.


Assuntos
Alcoolismo/epidemiologia , Alcoolismo/prevenção & controle , Atitude do Pessoal de Saúde , Percepção Social , Estudantes de Medicina/psicologia , Consumo de Bebidas Alcoólicas/epidemiologia , Consumo de Bebidas Alcoólicas/prevenção & controle , Alcoolismo/diagnóstico , Currículo/tendências , Feminino , Humanos , Masculino , Relatório de Pesquisa , Escócia/epidemiologia , Inquéritos e Questionários
6.
Artigo em Inglês | MEDLINE | ID: mdl-34430870

RESUMO

The therapy of autoimmune rheumatological conditions has undergone significant changes with the introduction of biologic antiinflammatory agents including cytokine antagonists and agents that interfere with the function of T and B cells or those that inhibit intracellular enzymes such as Janus kinase (JAK). Although useful to control inflammation, these agents may be associated with druginduced lung disease, which may be difficult to differentiate from pulmonary disorders caused by the underlying autoimmune diseases. This review aims to provide a description of lung disease, both infectious and non-infectious, that may be induced by the administration of biologic anti-inflammatory agents with emphasis on inhibitors of tumour necrosis factor, interleukin-1, interleukin-6 and JAK.

7.
Alcohol Alcohol ; 45(4): 395-7, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20501550

RESUMO

AIMS: This study was aimed to review and rewrite the undergraduate curriculum on alcohol use disorders, implement the changes and assess for any early evidence of an improvement in knowledge. METHODS: A three-stage process was used to review the old curriculum and a new one was designed around the five undergraduate years. Students' opinions were sought about the acceptability of the new curriculum using a questionnaire, to which 93 responded and 70 volunteers were objectively assessed using an examination based on questions from the text of the Medical Students' Handbook on Alcohol and Health. RESULTS: There was no evidence of any improvement in the students' knowledge using the old curriculum. After teaching with the new curriculum, examination scores significantly increased (P < 0.0001). There was no difference between the sexes. The new curriculum was assessed as acceptable to the students. CONCLUSION: This new curriculum reflects the need for a new teaching method and not only offers improved teaching, but also produces a generation of doctors equipped to identify alcohol-related problems and to deliver brief interventions, helping to reduce the projected consequences of alcohol abuse and the associated burden on the health service.


Assuntos
Transtornos Relacionados ao Uso de Álcool , Currículo , Educação de Graduação em Medicina/métodos , Feminino , Humanos , Masculino , Inquéritos e Questionários , Ensino
8.
Onderstepoort J Vet Res ; 76(4): 443-8, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21344793

RESUMO

The QRS response of the electrocardiogram to bleeding has been a source of interest to the physiologist for more than a century. Studies in the dog, cat and chicken have shown a reduction in QRS amplitude in response to bleeding. This effect has been explained by the so-called Brody effect, in which the intraventricular mass of blood acts as a conducting medium, augmenting radial conduction, thus resulting in the subsequent reduction in QRS amplitude in conditions where the intraventricular mass of blood is reduced. The aim of this study was to evaluate whether the Brody effect will be present in the ovine heart and, furthermore, to evaluate if the right and left ventricles will demonstrate the same QRS change if the Brody effect is indeed present. This study clearly demonstrated that the Brody effect is present in the ovine heart. Furthermore, two unique aspects emanating from this study are firstly the fact that this is the first study to show that premature ventricular complexes are able to induce the Brody effect and, secondly that there is a very clear difference in the response of the right and the left ventricles when the Brody effect is induced in the ovine heart.


Assuntos
Eletrocardiografia/veterinária , Ventrículos do Coração/fisiopatologia , Doenças dos Ovinos/etiologia , Complexos Ventriculares Prematuros/veterinária , Animais , Volume Sanguíneo , Condutividade Elétrica , Coração/fisiologia , Sistema de Condução Cardíaco/fisiologia , Masculino , Ovinos , Complexos Ventriculares Prematuros/complicações
9.
Med Teach ; 30(6): e157-60, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18608961

RESUMO

BACKGROUND: Healthcare associated infection affects 9% of patients admitted to hospital. One of the greatest challenges in addressing this problem is transferring theory to practice in relation to hand hygiene. Developing the ability to reflect can promote this transfer. This study illustrates how an instrument to assess the reflective ability of final year medical students was applied to the context of hand hygiene within the infection control cleanliness champion programme (CCP) and demonstrated inter-rater reliability at all three levels of reflection. The results suggest behaviour change in relation to practice. METHODS: One hundred and thirty two reflective accounts were used for this study, provided by 44 5th year medical students. Each student had written three reflective accounts for each part of the hand hygiene unit. Results show that the inter-rater agreement was consistently high for all three levels of reflection. However, the least consistent was at reflective level three. CONCLUSIONS: These results suggest that the students were able to link theory to practice following the completion of the CCP. It could also indicate that assessors might require more skills and knowledge to enable effective and consistent examination of all areas of reflection.


Assuntos
Infecção Hospitalar/prevenção & controle , Educação de Graduação em Medicina/métodos , Desinfecção das Mãos/normas , Controle de Infecções , Educação de Graduação em Medicina/normas , Humanos , Medicina Estatal , Estudantes de Medicina , Ensino/métodos
10.
Angiology ; 58(4): 502-3, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17636184

RESUMO

Hypertrophic cardiomyopathy is the term for a heterogeneous group of disorders for which various mutations of genes involving proteins of the cardiac sarcomere lead to hypertrophy of various segments of the left ventricle. The hypertrophy can involve the left and/or right ventricle, be symmetric or asymmetric, involving the septum, free wall, mid-ventricle, or apex. The phenomenon of solitary papillary muscle hypertrophy is rare with only 2 references in the literature. Furthermore, giant negative T and U waves are 2 common electrocardiographic phenomena in hypertrophic cardiomyopathy and have been attributed to hypertrophy of the posterior papillary muscle. Solitary hypertrophy of the anterior papillary muscle might be a new echo-electrocardiographic syndrome.


Assuntos
Cardiomiopatia Hipertrófica/diagnóstico , Músculos Papilares , Adulto , Cardiomiopatia Hipertrófica/fisiopatologia , Diagnóstico Diferencial , Ecocardiografia , Eletrocardiografia , Humanos , Hipertrofia , Masculino , Contração Miocárdica/fisiologia , Músculos Papilares/diagnóstico por imagem , Músculos Papilares/patologia , Músculos Papilares/fisiopatologia
11.
Med Teach ; 29(6): e151-9, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17978962

RESUMO

BACKGROUND: Although dying and death are common in practice, medical and social work students receive limited teaching on this topic. In addition, they have minimal experience of each others' role in the process, yet respecting the roles of other professionals in this delicate area is paramount to the delivery of high standards of care. In an attempt to address this, a pilot interprofessional 3 hour dying and death workshop was developed for senior social work and medical students using a constructivist approach to explore their own personal, uniprofessional and interprofessional roles in the dying and death process. METHODS: An expert group of health care professionals designed the workshop through an iterative process. The participants evaluated the workshop in relation to the levels of their learning journey at two time points using a combination of Likert scales and free text. RESULTS: An afternoon workshop was created comprising a trigger exercise to ascertain the students' own feelings, simulation of the practical aspects relating to a patient's death (confirmation of death, death certification and last offices), and discussion about the grief process, followed by case studies to consolidate their learning and highlight the interprofessional aspect. Eleven final year social work students and 14 medical students in their fourth year took part. Participants felt they gained most from the interprofessional aspect of their learning journey and suggested other topics for interprofessional learning. All students would recommend the workshop to their colleagues. CONCLUSIONS: This undergraduate interprofessional pilot dying and death workshop was well received and enabled learning on three levels--personal, professional and interprofessional. It promoted a greater understanding of the role of each student's own profession and appreciation of the role of other professionals in the dying and death process.


Assuntos
Atitude Frente a Morte , Educação de Graduação em Medicina , Serviço Social/educação , Estudantes de Ciências da Saúde/psicologia , Estudantes de Medicina/psicologia , Adulto , Feminino , Humanos , Masculino , Projetos Piloto
12.
J R Coll Physicians Edinb ; 47(2): 135-137, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28675182

RESUMO

Atrial fibrillation is the most common pathologic supraventricular tachycardia. It has many causes, is an expensive disease, impairs quality of life and leads to an increased risk of death. Atrial dissociation is characterised by the presence of two independent sets of P-waves. This peculiar abnormality may give rise to the scenario where one atrium is in atrial fibrillation while the other is in sinus rhythm. This is the first published case of atrial dissociation where the phenomenon is demonstrated by transmitral and transtricuspid pulsed wave Doppler.


Assuntos
Fibrilação Atrial/diagnóstico , Fibrilação Atrial/terapia , Bloqueio Cardíaco/diagnóstico , Bloqueio Cardíaco/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
13.
Intern Med J ; 36(5): 294-301, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16650194

RESUMO

BACKGROUND: The wide 95% confidence interval for S(a)O2 measured by pulse oximetry (S(P)O2) and the inherent characteristics of the oxyhaemoglobin dissociation curve can lead to modest but significant decreases in P(a)O2 (deltaP(a)O2 > or = 5 mmHg) that may be under-appreciated. AIM: To avoid missing potentially significant deltaP(a)O2 by using S(P)O2, this study establishes a threshold of deltaS(P)O2 to detect deltaP(a)O2 by examining the correlation between deltaS(P)O2 and deltaP(a)O2. METHODS: We enrolled 29 elderly patients with moderate to severe chronic obstructive pulmonary disease as assessed by lung function testing. Arterial blood gases and S(P)O2 measurements were carried out during maximal exercise testing. The patients were assigned to groups based on P(a)O2 measurements: group 1 had P(a)O2 at peak exercise (P(a)O2peak) > or = 60 mmHg without a deltaP(a)O2; group 2 had P(a)O2peak > or = 60 mmHg with a deltaP(a)O2; group 3 had P(a)O2peak < 60 mmHg without a deltaP(a)O2; and group 4 had P(a)O2peak < 60 mmHg with a deltaP(a)O2. RESULTS: The study population was evenly distributed between groups 1, 2 and 4. However, group 3 did not have any patients enrolled in this study that met group 3 criteria. The sensitivity of pulse oximetry required to detect S(a)O2 below 90% was 19%. DeltaS(P)O2 of 3% may increase the low sensitivity of S(P)O2 and was shown by a 92% positive predictive value for deltaP(a)O2 > or = 5 mmHg. CONCLUSION: This study suggests that important changes in oxygenation may be avoided if using deltaS(P)O2 rather than absolute values of S(P)O2 in patients with chronic obstructive pulmonary disease undergoing exercise testing to detect exercise-induced hypoxaemia.


Assuntos
Exercício Físico/fisiologia , Hipóxia/sangue , Oxigênio/sangue , Adulto , Idoso , Gasometria , Humanos , Hipóxia/complicações , Hipóxia/etiologia , Masculino , Pessoa de Meia-Idade , Pressão Parcial , Doença Pulmonar Obstrutiva Crônica/sangue , Doença Pulmonar Obstrutiva Crônica/complicações
14.
Onderstepoort J Vet Res ; 72(4): 273-7, 2005 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16562729

RESUMO

In this study we evaluated the validity of well-known human electrocardiographic markers of myocardial pathology in Dorper sheep. These markers include: the duration of the QRS complex of premature ventricular complexes (PVCs), the presence of notching of the QRS complex of PVCs and change of the ST-segment of PVCs. It was shown that these three electrocardiographic phenomena correlate with myocardial pathology in the hearts of Dorper sheep. We also describe a new electrocardiographic indicator of myocardial pathology, namely an increase in the frequency of cardiac memory T waves as a new electrocardiographic surrogate for myocardial pathology in the hearts of Dorper sheep.


Assuntos
Eletrocardiografia/veterinária , Sistema de Condução Cardíaco/patologia , Miocárdio/patologia , Doenças dos Ovinos/patologia , Ovinos/fisiologia , Animais , Eletrocardiografia/métodos , Coração/fisiologia , Sistema de Condução Cardíaco/fisiologia , Masculino
15.
Biochem Pharmacol ; 61(10): 1319-28, 2001 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-11322936

RESUMO

This study was designed to evaluate the effects of epinephrine (0.01-1 microM) on superoxide production by, and release of elastase from human neutrophils activated with the chemotactic tripeptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) (1 microM) in vitro, and to relate alterations in these responses to changes in adenosine 3,5' cyclic monophosphate (cAMP) and cytosolic free Ca(2+). Cyclic AMP, superoxide production and elastase release were measured by radioimmunoassay, lucigenin-enhanced chemiluminescence, and a colorimetric procedure respectively. Cytosolic Ca(2+) fluxes were measured by fura-2 spectrofluorimetry in combination with radiometric procedures that enable distinction between net efflux and influx of the cation. Epinephrine treatment of neutrophils resulted in increased cAMP and dose-related inhibition of both superoxide production and elastase release, which was potentiated by the type 4 phosphodiesterase inhibitor, rolipram, and attenuated by propranolol, but not by selective beta(1)-, alpha(1)- or alpha(2)-adrenoreceptor antagonists. Although epinephrine did not affect the FMLP-activated abruptly-occurring increase in fura-2 fluorescence intensity, indicating no effects on the release of Ca(2+) from neutrophil intracellular stores, this agent accelerated the rate of decline in fluorescence in the setting of decreased efflux and a reduction in store-operated influx of Ca(2+). These effects of epinephrine on the clearance of Ca(2+) from the cytosol of FMLP-activated neutrophils were attenuated by propranolol, and are compatible with enhancement of the activity of the cAMP-dependent Ca(2+) sequestering/resequestering endo-membrane Ca(2+)-ATPase. We conclude that epinephrine down-regulates the pro-inflammatory activities of neutrophils by cAMP-mediated enhancement of the clearance of cytosolic Ca(2+).


Assuntos
Epinefrina/farmacologia , Neutrófilos/efeitos dos fármacos , Elastase Pancreática/metabolismo , Superóxidos/metabolismo , Adulto , Transporte Biológico/efeitos dos fármacos , Cálcio/metabolismo , Radioisótopos de Cálcio , AMP Cíclico/metabolismo , Citosol/efeitos dos fármacos , Citosol/metabolismo , Corantes Fluorescentes/metabolismo , Fura-2/metabolismo , Humanos , Técnicas In Vitro , N-Formilmetionina Leucil-Fenilalanina/farmacologia , Ativação de Neutrófilo/efeitos dos fármacos , Neutrófilos/enzimologia , Neutrófilos/metabolismo , Vasoconstritores/farmacologia
16.
Biochem Pharmacol ; 60(7): 993-9, 2000 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-10974209

RESUMO

This study was undertaken to identify the adenosine receptor (AR) subtypes which down-regulate the proinflammatory activities of human neutrophils, as well as the involvement of adenosine 3',5'-cyclic monophosphate (cAMP) and its relationship to cellular handling of Ca(2+) in mediating these effects. Neutrophils were treated with varying concentrations (0.01-1 microM) of AR agonists operative at A(1) (N(6)-cyclopentyladenosine, CPA), A(2A) (2(4-[(2-carboxyethyl)phenyl]ethylamino)-5'-N-ethylcarboxamidoadenosi ne, CGS 21680), and A(3) (N(6)-(3-iodobenzyl-5'-N-methylcarbamoyladenosine, IB-MECA) receptors, after which they were activated with the chemoattractant, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP, 1 microM). Intracellular cAMP, superoxide, and elastase were assayed using radioimmunoassay, lucigenin-enhanced chemiluminescence (LECL), and colorimetric procedures, respectively, while changes in the concentrations of cytosolic Ca(2+) were monitored by fura-2-based spectrofluorimetry. CGS 21680, at all concentrations tested, inhibited superoxide production in a dose-related manner, while CPA and IB-MECA were effective only at the highest concentrations tested (0.5-1 microM). The release of elastase from activated neutrophils was also inhibited by all three AR agonists, but was more sensitive to CGS 21680 and IB-MECA than was superoxide production. The inhibitory effects of all 3 agonists on superoxide production and elastase release were associated with accelerated clearance of Ca(2+) from the cytosol of activated neutrophils, and were effectively neutralized by pretreatment of the cells with the highly selective A(2A)R antagonist, ZM 241385 (4-(2-[7-amino-2-(2-furyl)[1, 2,4]triazolo[2,3-a][1,3,5]triazin-5yl amino]ethyl)phenol). Increased cAMP was detected in neutrophils treated with CGS 21680 and IB-MECA (1 microM). These data support the involvement of the A(2A)R subtype in the suppression of superoxide production and degranulation by activated human neutrophils, probably by cAMP-mediated alterations in Ca(2+) handling.


Assuntos
Adenosina/análogos & derivados , Adenosina/farmacologia , Anti-Inflamatórios não Esteroides/farmacologia , Neutrófilos/efeitos dos fármacos , Fenetilaminas/farmacologia , Receptores Purinérgicos P1/metabolismo , Degranulação Celular/efeitos dos fármacos , AMP Cíclico/metabolismo , Fura-2/metabolismo , Humanos , Técnicas In Vitro , Neutrófilos/enzimologia , Neutrófilos/metabolismo , Elastase Pancreática/metabolismo , Espécies Reativas de Oxigênio/metabolismo , Receptor A2A de Adenosina , Receptores Purinérgicos P1/efeitos dos fármacos
17.
IEEE Trans Neural Netw ; 8(6): 1545-56, 1997.
Artigo em Inglês | MEDLINE | ID: mdl-18255755

RESUMO

The cerebellar model articulation controller (CMAC) neural network has the advantages of fast convergence speed and low computation complexity. However, it suffers from a low storage space utilization rate on weight memory. In this paper, we propose a direct weight address mapping approach, which can reduce the required weight memory size with a utilization rate near 100%. Based on such an address mapping approach, we developed a pipeline architecture to efficiently perform the addressing operations. The proposed direct weight address mapping approach also speeds up the computation for the generation of weight addresses. Besides, a CMAC hardware prototype used for color calibration has been implemented to confirm the proposed approach and architecture.

18.
Med Teach ; 23(4): 357-366, 2001 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12098382

RESUMO

The introduction of an outcome-based approach to education at Dundee Medical School in Scotland instigated a search for assessment methods that would appropriately assess the students' achievements in terms of the learning outcomes. Portfolio assessment has been developed for this purpose and has been adopted for the summative assessment of students in their final examination in Dundee. The contents of the portfolio and the assessment process have been defined and the first cohort of students to be assessed in this way has been studied. The evaluation of the approach demonstrated strong staff support. Students were also positive although with some reservations. It is concluded that portfolio assessment is a powerful approach to assessing a range of curriculum outcomes not easily assessed by other methods and is worthy of inclusion in the assessor's toolkit.

19.
Med Teach ; 23(6): 535-551, 2001 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-12098472

RESUMO

This guide is intended to inform medical teachers about the use of portfolios for student assessment. It provides a background to the topic, reviews the range of assessment purposes for which portfolios have been used, identifies possible portfolio contents and outlines the advantages of portfolio assessment with particular focus on assessing professionalism. The experience of one medical school, the University of Dundee, is presented as a case study. The current state of understanding of the technical, psychometric issues relating to portfolio assessment is clarified. The final part of the paper provides a practical guide for those wishing to design and implement portfolio assessment in their own institutions. Five steps in the portfolio assessment process are identified: documentation, reflection, evaluation, defence and decision. It is concluded that portfolio assessment is an important addition to the assessor's toolkit. Reasons for using portfolios for assessment purposes include the impact that they have in driving student learning and their ability to measure outcomes such as professionalism that are difficult to assess using traditional methods.

20.
Surgeon ; 1(4): 215-20, 2003 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-15570765

RESUMO

BACKGROUND: The aim of this study was to obtain consensus amongst consultant surgeons on the attributes of a good surgical trainer that can be used to inform continuing professional development programmes for trainers. METHODS: good trainer attributes were generated from an intensive qualitative study using a participative inquiry process with consultant general surgeons and specialist registrars in the Tayside region. These good trainer attributes were then used as the basis of a modified Delphi study; the early rounds of the Delphi simultaneously sought participants' views concerning stated attributes and sought to generate new attributes. A final Delphi questionnaire was sent to all 180 consultant general surgeons in Scotland to identify consensus. RESULTS: The first two rounds of the Delphi process produced 45 attributes covering seven themes: interest in training, trainer as a team member, communication, receptiveness to trainee needs, trainer as a role model, reflection on practice and clinical and operative competence. The final survey identified significant consensus among surgeons. Clinical and operative competence achieved the highest consensus with 89.2% of surgeons believing it to be an essential attribute. CONCLUSIONS: The results indicate that there is consensus on the seven themes identified as essential for a trainer in general surgery. The recognition of the importance by trainers of non-surgical trainer attributes in the changed training structure is encouraging. Surgeons' level of awareness of their roles as a trainer will help inform the level and direction of trainer training and support required as part of a flexible and continuing developmental process.


Assuntos
Educação de Pós-Graduação em Medicina , Cirurgia Geral/educação , Ensino , Docentes de Medicina , Humanos , Reino Unido
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