Detalhe da pesquisa
1.
Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug Conjugates.
J Am Chem Soc
; 138(4): 1430-45, 2016 Feb 03.
Artigo
Inglês
| MEDLINE | ID: mdl-26745435
2.
Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs.
Bioconjug Chem
; 27(9): 2081-8, 2016 09 21.
Artigo
Inglês
| MEDLINE | ID: mdl-27469406
3.
Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia.
J Med Chem
; 66(2): 1157-1171, 2023 01 26.
Artigo
Inglês
| MEDLINE | ID: mdl-36624931
4.
3-(Pyridin-2-yl-ethynyl)benzamide metabotropic glutamate receptor 5 negative allosteric modulators: hit to lead studies.
Bioorg Med Chem Lett
; 21(1): 195-9, 2011 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21126874
5.
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.
Nat Commun
; 12(1): 815, 2021 02 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33547286
6.
1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists.
Bioorg Med Chem Lett
; 20(16): 4816-8, 2010 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20638844
7.
Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists.
Bioorg Med Chem Lett
; 20(12): 3742-5, 2010 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20471258
8.
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II.
Bioorg Med Chem
; 18(1): 190-201, 2010 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19932972
9.
5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators.
Bioorg Med Chem Lett
; 19(23): 6666-9, 2009 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19864132
10.
Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).
J Med Chem
; 51(6): 1861-73, 2008 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-18318463
11.
1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators.
Bioorg Med Chem Lett
; 18(18): 5015-7, 2008 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18722119
12.
7-aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists.
Bioorg Med Chem
; 16(13): 6589-600, 2008 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18504132
13.
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.
J Med Chem
; 52(1): 105-16, 2009 Jan 08.
Artigo
Inglês
| MEDLINE | ID: mdl-19072540
14.
A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.
Bone
; 44(6): 1063-8, 2009 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-19254787
15.
SAR studies of 6-(arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones as progesterone receptor antagonists.
Bioorg Med Chem Lett
; 17(1): 189-92, 2007 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17027272