1.
Org Lett
; 8(24): 5441-3, 2006 Nov 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17107042
RESUMO
The first enantioselective total synthesis of (S)-equol is reported. The described route relies on an Evans alkylation to form the stereocenter and an intramolecular Buchwald etherification to generate the chroman ring. Key features of this method include its brevity, its scalability, and the low cost of starting materials. [reaction: see text].
Assuntos
Isoflavonas/síntese química , Alquilação , Cromanos/síntese química , Cromatografia Líquida de Alta Pressão , Equol , Éteres/síntese química , Indicadores e Reagentes , Estereoisomerismo
2.
ACS Med Chem Lett
; 2(2): 124-9, 2011 Feb 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24900290
RESUMO
This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described.