[Mechanism of the adjuvant action: effect on the stem cell and B-lymphocyte migration from the bone marrow]. / K mekhanizmu deistviia ad'iuvantov: vliianie na migratsiiu stvolovykh kletok i B-limfotsitov iz kostnogo mozga.

The authors studied the influence of synthetic polyelectrolytes of polyacrylic acid and poly-2-methyl-5-vinylpyridine and of complete Freund's adjuvant on the migration of stem cells and B-lymphocytes from mouse bone marrow. The stem cell count was evaluated by the number of splenic colonies; as to B-cell migration--it was assessed by the accumulation of the antibody-forming cells forming from B-lymphocytes migrating in the spleen in the transfer of fixed number of T-lymphocytes. As revealed the synthetic substances under study intensified the migration of stem cells and of B-lymphocytes to a much greater extent than Freund's adjuvant. The mechanisms of the influence of the adjuvants used on cell migration processes are discussed.

[Regulatory role of the bone marrow in immunogenesis. 1. Bone marrow suppressor cells in the in vitro culture]. / Reguliatornaia rol' kostnogo mozga v immunogeneze. Soobschenie 1. Kostno-mozgovye kletki-supressory v kul'ture in vitro.

Bone marrow cells added to the spleen cell culture (after Mishell and Dutton) stimulated with sheep red blood cells suppressed the production of plaque-forming cells. Bone marrow supressors-cells bear surface immunoglobulins and MBLA, they are referred to the actively prolferating cells, and, apparently, represent immature cells-precursors of B-lymphocytic series.