Detalhe da pesquisa
1.
Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy.
Med Res Rev
; 44(2): 686-706, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-37983866
2.
Selective, C-3 Friedel-Crafts acylation to generate functionally diverse, acetylated Imidazo[1,2-a]pyridine derivatives.
Tetrahedron
; 74(35): 4592-4600, 2018 Aug 30.
Artigo
Inglês
| MEDLINE | ID: mdl-30344351
3.
Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose.
J Med Chem
; 65(2): 1536-1551, 2022 01 27.
Artigo
Inglês
| MEDLINE | ID: mdl-35081714
4.
Tocotrienols as an Anti-Breast Cancer Agent.
Antioxidants (Basel)
; 10(9)2021 Aug 29.
Artigo
Inglês
| MEDLINE | ID: mdl-34573015
5.
Discovery of 4-aminoquinolines as highly selective TGFßR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology.
Eur J Med Chem
; 225: 113763, 2021 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34419892
6.
Discovery and biological evaluation of phthalazines as novel non-kinase TGFß pathway inhibitors.
Eur J Med Chem
; 223: 113660, 2021 Nov 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34246853
7.
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG.
Adv Sci (Weinh)
; 8(20): e2102555, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34397171
8.
Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor.
Eur J Med Chem
; 225: 113776, 2021 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34479037
9.
The Exploration of Chirality for Improved Druggability within the Human Kinome.
J Med Chem
; 63(2): 441-469, 2020 01 23.
Artigo
Inglês
| MEDLINE | ID: mdl-31550151
10.
Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts.
Chem Commun (Camb)
; 54(92): 12954-12957, 2018 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30375586