Detalhe da pesquisa
1.
Definition of a Threshold for the Plasma Aß42/Aß40 Ratio Measured by Single-Molecule Array to Predict the Amyloid Status of Individuals without Dementia.
Int J Mol Sci
; 25(2)2024 Jan 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38256246
2.
Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide.
J Biol Chem
; 294(15): 5854-5866, 2019 04 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30755484
3.
How to Build and to Protect the Neuromuscular Junction: The Role of the Glial Cell Line-Derived Neurotrophic Factor.
Int J Mol Sci
; 22(1)2020 Dec 24.
Artigo
Inglês
| MEDLINE | ID: mdl-33374485
4.
Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
J Cell Mol Med
; 22(2): 823-833, 2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-28994238
5.
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.
Acta Neuropathol
; 133(5): 731-749, 2017 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28083634
6.
APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation.
FASEB J
; 30(5): 1696-711, 2016 05.
Artigo
Inglês
| MEDLINE | ID: mdl-26718890
7.
Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.
J Biol Chem
; 290(11): 7169-84, 2015 Mar 13.
Artigo
Inglês
| MEDLINE | ID: mdl-25614624
8.
Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease.
J Neuroinflammation
; 13: 20, 2016 Jan 27.
Artigo
Inglês
| MEDLINE | ID: mdl-26818951
9.
Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.
Acta Neuropathol
; 131(4): 549-69, 2016 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-26739002
10.
Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.
Acta Neuropathol
; 129(6): 875-94, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25862635
11.
Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.
FASEB J
; 28(6): 2620-31, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24604080
12.
Gamma-secretase inhibitor activity of a Pterocarpus erinaceus extract.
Neurodegener Dis
; 14(1): 39-51, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24192706
13.
Structural features of the KPI domain control APP dimerization, trafficking, and processing.
FASEB J
; 26(2): 855-67, 2012 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-22085646
14.
Specific post-translational modifications of soluble tau protein distinguishes Alzheimer's disease and primary tauopathies.
Nat Commun
; 14(1): 3706, 2023 06 22.
Artigo
Inglês
| MEDLINE | ID: mdl-37349319
15.
Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-ß accumulation in a mouse model of amyloid pathology.
Acta Neuropathol Commun
; 11(1): 82, 2023 05 17.
Artigo
Inglês
| MEDLINE | ID: mdl-37198698
16.
A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.
Proc Natl Acad Sci U S A
; 106(5): 1421-6, 2009 Feb 03.
Artigo
Inglês
| MEDLINE | ID: mdl-19164538
17.
Deconstruction of Neurotrypsin Reveals a Multi-factorially Regulated Activity Affecting Myotube Formation and Neuronal Excitability.
Mol Neurobiol
; 59(12): 7466-7485, 2022 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-36197591
18.
Structural Determinant of ß-Amyloid Formation: From Transmembrane Protein Dimerization to ß-Amyloid Aggregates.
Biomedicines
; 10(11)2022 Oct 29.
Artigo
Inglês
| MEDLINE | ID: mdl-36359274
19.
An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-ß.
Sci Rep
; 11(1): 11570, 2021 06 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34078941
20.
Erratum: Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization.
iScience
; 24(2): 102057, 2021 Feb 19.
Artigo
Inglês
| MEDLINE | ID: mdl-33554063