Detalhe da pesquisa
1.
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Bioorg Med Chem Lett
; 27(8): 1840-1847, 2017 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28274633
2.
Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
Bioorg Med Chem Lett
; 25(5): 1040-3, 2015 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25650256
3.
Preclinical characterization of the novel hepatitis C virus NS3 protease inhibitor GS-9451.
Antimicrob Agents Chemother
; 58(2): 647-53, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-23939899
4.
Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.
Antimicrob Agents Chemother
; 58(4): 1943-51, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24419340
5.
Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
Antimicrob Agents Chemother
; 58(4): 1930-42, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24419349
6.
Novel, sulfonamide linked inhibitors of the hepatitis C virus NS3 protease.
Bioorg Med Chem Lett
; 24(3): 969-72, 2014 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24405705
7.
Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 24(14): 3092-5, 2014 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24907145
8.
Novel, potent and orally bioavailable indolizidinone-derived inhibitors of the hepatitis C virus NS3 protease.
Bioorg Med Chem Lett
; 22(2): 1095-8, 2012 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22189140
9.
Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides.
Bioorg Med Chem Lett
; 22(8): 2705-7, 2012 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22446091
10.
Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.
Bioorg Med Chem Lett
; 22(12): 4127-32, 2012 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22578461
11.
Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.
Bioorg Med Chem Lett
; 22(7): 2629-34, 2012 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22366653
12.
Discovery of GS-9256: a novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity.
Bioorg Med Chem Lett
; 22(3): 1394-6, 2012 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22244938
13.
Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease.
Bioorg Med Chem Lett
; 21(12): 3568-72, 2011 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21601450
14.
SAR studies on dihydropyrimidinone antibiotics.
Bioorg Med Chem Lett
; 21(6): 1670-4, 2011 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21324685
15.
N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg Med Chem Lett
; 20(5): 1589-92, 2010 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20138513
16.
N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg Med Chem Lett
; 20(5): 1585-8, 2010 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20137928
17.
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.
Antimicrob Agents Chemother
; 53(3): 1194-203, 2009 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19104010
18.
Tricyclic HIV integrase inhibitors: VI. SAR studies of 'benzyl flipped' C3-substituted pyrroloquinolines.
Bioorg Med Chem Lett
; 19(4): 1187-90, 2009 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19167883
19.
Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.
Bioorg Med Chem Lett
; 19(8): 2263-5, 2009 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19285389
20.
Discovery of novel phosphonate derivatives as hepatitis C virus NS3 protease inhibitors.
Bioorg Med Chem Lett
; 19(13): 3453-7, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19477126