Detalhe da pesquisa
1.
Development of Cilofexor, an intestinally-biased Farnesoid X Receptor agonist, for the treatment of fatty liver disease.
J Pharmacol Exp Ther
; 2024 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38409114
2.
Discovery and optimization of substituted oxalamides as novel heme-displacing IDO1 inhibitors.
Bioorg Med Chem Lett
; 33: 127744, 2021 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33333163
3.
Discovery of highly potent heme-displacing IDO1 inhibitors based on a spirofused bicyclic scaffold.
Bioorg Med Chem Lett
; 33: 127738, 2021 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33316404
4.
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.
Bioorg Med Chem Lett
; 30(12): 127205, 2020 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32336498
5.
Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.
Bioorg Med Chem Lett
; 30(12): 127174, 2020 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32334912
6.
Nonsteroidal FXR Ligands: Current Status and Clinical Applications.
Handb Exp Pharmacol
; 256: 167-205, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31197565
7.
Identification and biological evaluation of thiazole-based inverse agonists of RORγt.
Bioorg Med Chem Lett
; 28(9): 1446-1455, 2018 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29631962
8.
Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties.
Bioorg Med Chem Lett
; 26(15): 3746-53, 2016 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27268696
9.
The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein.
Int J Cancer
; 136(11): 2693-704, 2015 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25363753
10.
Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice.
J Pharmacol Exp Ther
; 343(3): 556-67, 2012 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-22918042
11.
Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 1.
Bioorg Med Chem Lett
; 21(15): 4422-8, 2011 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21737272
12.
Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2.
Bioorg Med Chem Lett
; 21(15): 4429-35, 2011 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21737263
13.
Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534.
Sci Rep
; 11(1): 11066, 2021 05 26.
Artigo
Inglês
| MEDLINE | ID: mdl-34040108
14.
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.
Bioorg Med Chem Lett
; 20(16): 4911-7, 2010 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20638278
15.
Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).
Bioorg Med Chem Lett
; 20(3): 1094-9, 2010 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20031401
16.
Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells.
Bioorg Med Chem Lett
; 20(3): 1100-5, 2010 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20022747
17.
Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation.
ACS Med Chem Lett
; 11(2): 179-187, 2020 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-32071686
18.
3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 19(7): 1930-4, 2009 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19269170
19.
Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway.
Bioorg Med Chem Lett
; 19(15): 4191-5, 2009 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19540115
20.
A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo.
J Med Chem
; 51(8): 2350-3, 2008 Apr 24.
Artigo
Inglês
| MEDLINE | ID: mdl-18370373