Detalhe da pesquisa
1.
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans.
Nature
; 477(7362): 99-102, 2011 Aug 31.
Artigo
Inglês
| MEDLINE | ID: mdl-21886163
2.
First-in-man study of western reserve strain oncolytic vaccinia virus: safety, systemic spread, and antitumor activity.
Mol Ther
; 23(1): 202-14, 2015 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-25292189
3.
Phase 1 study of intratumoral Pexa-Vec (JX-594), an oncolytic and immunotherapeutic vaccinia virus, in pediatric cancer patients.
Mol Ther
; 23(3): 602-8, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25531693
4.
Thrombotic microangiopathy following systemic AAV administration is dependent on anti-capsid antibodies.
J Clin Invest
; 134(1)2024 Jan 02.
Artigo
Inglês
| MEDLINE | ID: mdl-37988172
5.
The oncolytic poxvirus JX-594 selectively replicates in and destroys cancer cells driven by genetic pathways commonly activated in cancers.
Mol Ther
; 20(4): 749-58, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22186794
6.
A mechanistic proof-of-concept clinical trial with JX-594, a targeted multi-mechanistic oncolytic poxvirus, in patients with metastatic melanoma.
Mol Ther
; 19(10): 1913-22, 2011 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-21772252
7.
Sequential therapy with JX-594, a targeted oncolytic poxvirus, followed by sorafenib in hepatocellular carcinoma: preclinical and clinical demonstration of combination efficacy.
Mol Ther
; 19(6): 1170-9, 2011 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-21427706
8.
A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers.
Mol Ther
; 18(6): 1123-9, 2010 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-20389287
9.
Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing.
Mol Cancer Ther
; 20(8): 1481-1494, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34045231
10.
Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963.
J Clin Invest
; 117(11): 3350-8, 2007 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-17965776
11.
Oncolytic virotherapy for advanced liver tumours.
J Cell Mol Med
; 13(7): 1238-47, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19175689
12.
The targeted oncolytic poxvirus JX-594 demonstrates antitumoral, antivascular, and anti-HBV activities in patients with hepatocellular carcinoma.
Mol Ther
; 16(9): 1637-42, 2008 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-18628758
13.
Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial.
Lancet Oncol
; 9(6): 533-42, 2008 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-18495536
14.
Randomized phase 3 trial of interferon gamma-1b plus standard carboplatin/paclitaxel versus carboplatin/paclitaxel alone for first-line treatment of advanced ovarian and primary peritoneal carcinomas: results from a prospectively designed analysis of progression-free survival.
Gynecol Oncol
; 109(2): 174-81, 2008 May.
Artigo
Inglês
| MEDLINE | ID: mdl-18314182
15.
Oncolytic adenoviruses for cancer gene therapy.
Methods Mol Biol
; 433: 243-58, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18679628
16.
Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms.
Cancer Res
; 78(4): 922-937, 2018 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29259007
17.
Targeting of interferon-beta to produce a specific, multi-mechanistic oncolytic vaccinia virus.
PLoS Med
; 4(12): e353, 2007 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-18162040
18.
Redemption for the field of oncolytic virotherapy.
Mol Ther
; 19(4): 627-8, 2011 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-21455205
19.
Validation and analysis of a mathematical model of a replication-competent oncolytic virus for cancer treatment: implications for virus design and delivery.
Cancer Res
; 63(6): 1317-24, 2003 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-12649193
20.
Oncolytic activity of the E1B-55 kDa-deleted adenovirus ONYX-015 is independent of cellular p53 status in human malignant glioma xenografts.
Cancer Res
; 62(3): 764-72, 2002 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-11830531