Multi-sensory feedback improves spatially compatible sensori-motor responses.

To interact with machines, from computers to cars, we need to monitor multiple sensory stimuli, and respond to them with specific motor actions. It has been shown that our ability to react to a sensory stimulus is dependent on both the stimulus modality, as well as the spatial compatibility of the stimulus and the required response. However, the compatibility effects have been examined for sensory modalities individually, and rarely for scenarios requiring individuals to choose from multiple actions. Here, we compared response time of participants when they had to choose one of several spatially distinct, but compatible, responses to visual, tactile or simultaneous visual and tactile stimuli. We observed that the presence of both tactile and visual stimuli consistently improved the response time relative to when either stimulus was presented alone. While we did not observe a difference in response times of visual and tactile stimuli, the spatial stimulus localization was observed to be faster for visual stimuli compared to tactile stimuli.

[A case of multiple liver metastasis from remnant gastric cancer responding to leucovorin.5-FU+UFT therapy].

We report a case of a 67-year-old male patient who experienced multiple liver metastasis 6 months after undergoing an operation for remnant gastric cancer. The histological classification of the cancer in gastric remnant was poorly-differentiated adenocarcinoma. The patient was treated with a low dose of LV.5-FU once a week and oral UFT as an outpatient. As a result, after 3 months of the treatment, CT showed that multiple liver lesions almost disappeared, a condition that lasted about 3 years without relapse. Toxic effects due to this treatment were temporary slight liver disfunction, mild anorexia and stomatitis. This case indicates that the regimen of LV.5-FU+UFT may be effective for multiple liver metastasis from postoperative remnant gastric cancer, enabling the patient to maintain an excellent QOL (quality of life).

[Continuous intraarterial infusion of 5-fluorouracil plus leucovorin for liver metastases from colorectal cancer].

Between September 1990 and August 1994, 11 patients (pts) with liver metastases (mets) from colorectal cancer were treated with continuous hepatic arterial infusion chemotherapy of 5-fluorouracil (FU) plus leucovorin (LV). Eight pts had non-resectable liver mets (H3: 7, H2: 1), and 3 had residual small mets after resection of major mets. Drugs were administered via an extracorporeal infusion device connected to the hepatic arterial infusion port. 5-FU and LV were given through a 5- to 7-day continuous infusion at 500-750 mg/body/day and 30 mg/body/day, respectively, with a 3- to 4-week rest period. In the recent 6 pts, cisplatin was administered as a 2-hour infusion at 25 mg/body, one or two times simultaneously. Grade 2 toxicity was noted in two pts (18%). One was stomatitis and another was uncontrolled ascites in an advanced cirrhotic pt. The response rate in the 9 evaluable pts was 67% with 6 PR and no CR. The duration of the response was 5 to 9 months. One- and two-year survival rates were 75% and 22%, respectively. These results were superior to those of the intermittent bolus injection of 5-FU plus MMC (or epirubicin) in 40 pts from 1977 to 1994. These results suggest that continuous 5-FU plus LV arterial infusion is an effective regimen in pts with liver metastases from colorectal cancer. However, the infusion with an extracorporeal device limits the pts' quality of life. Further investigation is needed for a schedule that can be practiced for a longer period.

Effects of color information on face processing using event-related potentials and gamma oscillations.

In humans, face configuration, contour and color may affect face perception, which is important for social interactions. This study aimed to determine the effect of color information on face perception by measuring event-related potentials (ERPs) during the presentation of natural- and bluish-colored faces. Our results demonstrated that the amplitude of the N170 event-related potential, which correlates strongly with face processing, was higher in response to a bluish-colored face than to a natural-colored face. However, gamma-band activity was insensitive to the deviation from a natural face color. These results indicated that color information affects the N170 associated with a face detection mechanism, which suggests that face color is important for face detection.

[Cytological and ultrastructural studies of cervical adenocarcinoma according to histological types].

This report describes the characteristic features of the exfoliated cells according to histological types, such as the type of early cervical adenocarcinoma for the diagnosis of cervical carcinoma of adenoid type (hereinafter called cervical adenocarcinoma). Further, the characteristics of cervical adenocarcinoma and its histogenesis were studied in an ultrastructural approach and we obtained the following results. 1) The exfoliated cells of adenocarcinoma in situ (hereinafter called AIS) show the characteristic features that assist the early detection of cancer. 2) The histological types for diagnostic use in characterizing the exfoliated cells are clear cell adenocarcinoma and adenosquamous carcinoma. Further, the histological structure of both well differentiated and poorly differentiated endocervical types can be deduced from the cytologic features. 3) Since the transitional cells of both squamous and columnar types and also the intestinal epithelial metaplastic cells were ultrastructurally observed in adenosquamous carcinoma and adenoacanthoma, the reserve cells are considered to act as an original cell and eventually participate in the histogenesis of these types of carcinomas. 4) The cells of both secretory granules and tonofibrils were detected in the AIS foci. This finding indicates the involvement of the subcolumnar basal cells which can eventually be differentiated into the secretory or ciliated cells of the columnar epithelium of the endocervical canal during the histogenesis of cervical adenocarcinoma of the endocervical type.

Surface discontinuity is critical in a moving observer's perception of objects' depth order and relative motion from retinal image motion.

The visual system perceptually decomposes retinal image motion into three basic components that are ecologically significant for the human observer: object depth, object motion, and self motion. Using this conceptual framework, we explored the relationship between them by examining perception of objects' depth order and relative motion during self motion. We found that the visual system obeyed what we call the parallax-sign constraint, but in different ways depending on whether the retinal image motion contained velocity discontinuity or not. When velocity discontinuity existed (e.g. in dynamic occlusion, transparent motion), the subject perceptually interpreted image motion as relative motion between surfaces with stable depth order. When velocity discontinuity did not exist, he/she perceived depth-order reversal but no relative motion. The results suggest that the existence of surface discontinuity or of multiple surfaces indexed by velocity discontinuity inhibits the reversal of global depth order.

'Generic-view principle' for three-dimensional-motion perception: optics and inverse optics of a moving straight bar.

The generic-view principle (GVP) states that given a 2-D image the visual system interprets it as a generic view of a 3-D scene when possible. The GVP was applied to 3-D-motion perception to show how the visual system decomposes retinal image motion into three components of 3-D motion: stretch/shrinkage, rotation, and translation. First, the optical process of retinal image motion was analyzed, and predictions were made based on the GVP in the inverse-optical process. Then experiments were conducted in which the subject judged perception of stretch/shrinkage, rotation in depth, and translation in depth for a moving bar stimulus. Retinal-image parameters-2-D stretch/shrinkage, 2-D rotation, and 2-D translation-were manipulated categorically and exhaustively. The results were highly consistent with the predictions. The GVP seems to offer a broad and general framework for understanding the ambiguity-solving process in motion perception. Its relationship to other constraints such as that of rigidity is discussed.