Detalhe da pesquisa
1.
Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.
Nucleic Acids Res
; 45(11): 6334-6349, 2017 Jun 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28369619
2.
Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance.
Int J Cancer
; 142(5): 968-975, 2018 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29055107
3.
Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels.
Antiviral Res
; 221: 105769, 2024 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38056603
4.
Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti-SARS-CoV-2 Activity.
ChemMedChem
; : e202400292, 2024 Jun 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38887198
5.
Safety and Dose-Response of Vidofludimus Calcium in Relapsing Multiple Sclerosis: Extended Results of a Placebo-Controlled Phase 2 Trial.
Neurol Neuroimmunol Neuroinflamm
; 11(3): e200208, 2024 May.
Artigo
Inglês
| MEDLINE | ID: mdl-38662979
6.
Development of a Potent Nurr1 Agonist Tool for In Vivo Applications.
J Med Chem
; 66(9): 6391-6402, 2023 05 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37127285
7.
Safety, Tolerability, and Pharmacokinetics of IMU-935, a Novel Inverse Agonist of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γt: Results From a Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study.
Clin Pharmacol Drug Dev
; 12(5): 525-534, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36938862
8.
Safety and Efficacy of Vidofludimus Calcium in Patients Hospitalized with COVID-19: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial.
Infect Dis Ther
; 11(6): 2159-2176, 2022 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-36242741
9.
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators.
ACS Chem Biol
; 17(11): 3159-3168, 2022 11 18.
Artigo
Inglês
| MEDLINE | ID: mdl-36318238
10.
Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication.
iScience
; 25(5): 104293, 2022 May 20.
Artigo
Inglês
| MEDLINE | ID: mdl-35492218
11.
Notch1, Notch2, and Epstein-Barr virus-encoded nuclear antigen 2 signaling differentially affects proliferation and survival of Epstein-Barr virus-infected B cells.
Blood
; 113(22): 5506-15, 2009 May 28.
Artigo
Inglês
| MEDLINE | ID: mdl-19339697
12.
Methodological Development of a Multi-Readout Assay for the Assessment of Antiviral Drugs against SARS-CoV-2.
Pathogens
; 10(9)2021 Aug 25.
Artigo
Inglês
| MEDLINE | ID: mdl-34578109
13.
Safety, Tolerability and Pharmacokinetics of Vidofludimus calcium (IMU-838) After Single and Multiple Ascending Oral Doses in Healthy Male Subjects.
Eur J Drug Metab Pharmacokinet
; 45(5): 557-573, 2020 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-32361977
14.
Vidofludimus calcium, a next generation DHODH inhibitor for the Treatment of relapsing-remitting multiple sclerosis.
Mult Scler Relat Disord
; 43: 102129, 2020 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-32428844
15.
Clinical relevance of intestinal barrier dysfunction in common gastrointestinal diseases.
World J Gastrointest Pathophysiol
; 11(6): 114-130, 2020 Dec 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33362939
16.
Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro.
Viruses
; 12(8)2020 07 29.
Artigo
Inglês
| MEDLINE | ID: mdl-32751087
17.
IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro.
Viruses
; 12(12)2020 12 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33291455
18.
The Selective Oral Immunomodulator Vidofludimus in Patients with Active Rheumatoid Arthritis: Safety Results from the COMPONENT Study.
Drugs R D
; 19(4): 351-366, 2019 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-31621054
19.
Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells.
J Hematol Oncol
; 12(1): 30, 2019 03 18.
Artigo
Inglês
| MEDLINE | ID: mdl-30885250
20.
Notch signaling in embryonic and adult myelopoiesis.
Cells Tissues Organs
; 188(1-2): 91-102, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18196925