Detalhe da pesquisa
1.
Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249.
Bioorg Med Chem Lett
; 29(13): 1601-1604, 2019 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31072652
2.
Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges.
Bioorg Med Chem Lett
; 25(3): 690-4, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25542588
3.
Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists.
J Med Chem
; 49(14): 4140-52, 2006 Jul 13.
Artigo
Inglês
| MEDLINE | ID: mdl-16821774
4.
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).
J Med Chem
; 57(18): 7804-10, 2014 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-25147929
5.
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe.
ChemMedChem
; 9(8): 1677-82, 2014 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-24692176
6.
Lewis acid catalysis in water with a hydrophilic substrate: scandium-catalyzed hydroxymethylation with aqueous formaldehyde in water.
Angew Chem Int Ed Engl
; 47(36): 6909-11, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18666189
7.
Suppressive effects of a novel CC chemokine receptor 4 antagonist on Th2 cell trafficking in ligand- and antigen-induced mouse models.
Eur J Pharmacol
; 720(1-3): 335-43, 2013 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24140571
8.
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).
J Med Chem
; 56(22): 9351-5, 2013 Nov 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24164599
9.
One-Pot Sequential Asymmetric Hydrogenation Utilizing Rh(I) and Ru(II) Catalysts.
J Org Chem
; 63(3): 428-429, 1998 Feb 06.
Artigo
Inglês
| MEDLINE | ID: mdl-11672026
10.
Nazarov-type reactions in water.
Chem Asian J
; 4(4): 526-8, 2009 Apr 06.
Artigo
Inglês
| MEDLINE | ID: mdl-19212964
11.
Chiral scandium-catalyzed enantioselective hydroxymethylation of ketones in water.
Chem Asian J
; 5(3): 490-2, 2010 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20063342