Detalhe da pesquisa
1.
The human microbiome encodes resistance to the antidiabetic drug acarbose.
Nature
; 600(7887): 110-115, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34819672
2.
Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response.
Mol Cell
; 75(6): 1218-1228.e6, 2019 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31494033
3.
Structural basis of the unfolded protein response.
Annu Rev Cell Dev Biol
; 28: 251-77, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-23057742
4.
Structure of human NADK2 reveals atypical assembly and regulation of NAD kinases from animal mitochondria.
Proc Natl Acad Sci U S A
; 119(26): e2200923119, 2022 06 28.
Artigo
Inglês
| MEDLINE | ID: mdl-35733246
5.
2-5A-Mediated decay (2-5AMD): from antiviral defense to control of host RNA.
Crit Rev Biochem Mol Biol
; 57(5-6): 477-491, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36939319
6.
Introns encode dsRNAs undetected by RIG-I/MDA5/interferons and sensed via RNase L.
Proc Natl Acad Sci U S A
; 118(46)2021 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-34772806
7.
Real-time 2-5A kinetics suggest that interferons ß and λ evade global arrest of translation by RNase L.
Proc Natl Acad Sci U S A
; 116(6): 2103-2111, 2019 02 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30655338
8.
A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.
PLoS Genet
; 13(11): e1007072, 2017 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-29117179
9.
Rapid RNase L-driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery.
RNA
; 23(11): 1660-1671, 2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28808124
10.
Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3.
Proc Natl Acad Sci U S A
; 112(13): 3949-54, 2015 Mar 31.
Artigo
Inglês
| MEDLINE | ID: mdl-25775560
11.
Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome.
Proc Natl Acad Sci U S A
; 112(52): 15916-21, 2015 Dec 29.
Artigo
Inglês
| MEDLINE | ID: mdl-26668391
12.
Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1.
Proc Natl Acad Sci U S A
; 110(5): 1652-7, 2013 Jan 29.
Artigo
Inglês
| MEDLINE | ID: mdl-23319625
13.
Messenger RNA targeting to endoplasmic reticulum stress signalling sites.
Nature
; 457(7230): 736-40, 2009 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-19079237
14.
The unfolded protein response signals through high-order assembly of Ire1.
Nature
; 457(7230): 687-93, 2009 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-19079236
15.
Cryo-EM Structure of HRSL Domain Reveals Activating Crossed Helices at the Core of GCN2.
bioRxiv
; 2024 Apr 25.
Artigo
Inglês
| MEDLINE | ID: mdl-38712127
16.
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering.
Proc Natl Acad Sci U S A
; 107(37): 16113-8, 2010 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-20798350
17.
Structural and functional basis for RNA cleavage by Ire1.
BMC Biol
; 9: 47, 2011 Jul 06.
Artigo
Inglês
| MEDLINE | ID: mdl-21729333
18.
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1.
BMC Biol
; 9: 48, 2011 Jul 06.
Artigo
Inglês
| MEDLINE | ID: mdl-21729334
19.
The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues.
Biochemistry
; 50(14): 3004-13, 2011 Apr 12.
Artigo
Inglês
| MEDLINE | ID: mdl-21417210
20.
The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins.
Nat Struct Mol Biol
; 13(5): 436-43, 2006 May.
Artigo
Inglês
| MEDLINE | ID: mdl-16604082