Detalhe da pesquisa
1.
Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey.
J Pharmacol Exp Ther
; 377(1): 169-180, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33509903
2.
In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey.
J Pharmacol Exp Ther
; 365(3): 688-699, 2018 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29643253
3.
Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey.
Drug Metab Dispos
; 46(8): 1179-1189, 2018 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-29880631
4.
Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance.
Drug Metab Dispos
; 46(7): 989-1000, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29720472
5.
Novel Method to Predict In Vivo Liver-to-Plasma Kpuu for OATP Substrates Using Suspension Hepatocytes.
Drug Metab Dispos
; 45(5): 576-580, 2017 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28258068
6.
Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides.
Drug Metab Dispos
; 45(7): 721-733, 2017 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28396527
7.
Relative contributions of cytochrome CYP3A4 versus CYP3A5 for CYP3A-cleared drugs assessed in vitro using a CYP3A4-selective inactivator (CYP3cide).
Drug Metab Dispos
; 42(7): 1163-73, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-24737844
8.
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
J Med Chem
; 64(1): 644-661, 2021 01 14.
Artigo
Inglês
| MEDLINE | ID: mdl-33356246
9.
Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats.
Bioorg Med Chem Lett
; 20(21): 6262-7, 2010 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20829042
10.
Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro-In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs.
J Pharm Sci
; 106(9): 2795-2804, 2017 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28456723
11.
Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate.
ACS Med Chem Lett
; 5(5): 474-9, 2014 May 08.
Artigo
Inglês
| MEDLINE | ID: mdl-24900864
12.
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
J Med Chem
; 55(3): 1318-33, 2012 Feb 09.
Artigo
Inglês
| MEDLINE | ID: mdl-22196621
13.
Impact of time-dependent inactivation on the estimation of enzyme kinetic parameters for midazolam.
Drug Metab Lett
; 3(1): 45-53, 2009 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-19356116