An analysis of quantum effects on the thermodynamic properties of cryogenic hydrogen using the path integral method.

In this paper, we describe the analysis of the thermodynamic properties of cryogenic hydrogen using classical molecular dynamics (MD) and path integral MD (PIMD) method to understand the effects of the quantum nature of hydrogen molecules. We performed constant NVE MD simulations across a wide density-temperature region to establish an equation of state (EOS). Moreover, the quantum effect on the difference of molecular mechanism of pressure-volume-temperature relationship was addressed. The EOS was derived based on the classical mechanism idea only using the MD simulation results. Simulation results were compared with each MD method and experimental data. As a result, it was confirmed that although the EOS on the basis of classical MD cannot reproduce the experimental data of saturation property of hydrogen in the high-density region, the EOS on the basis of PIMD well reproduces those thermodynamic properties of hydrogen. Moreover, it was clarified that taking quantum effects into account makes the repulsion force larger and the potential well shallower. Because of this mechanism, the intermolecular interaction of hydrogen molecules diminishes and the virial pressure increases.

Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia.

Benzodiazepine (diazepam), triazolobenzodiazepines (brotizolam, triazolam) and platelet activating factor (PAF) antagonist (BN 52021) are administered to mice before acquisition and retrieval trials conducted using Morris water maze. Benzodiazepine has produced only anterograde amnesia and it has not produced retrograde amnesia. Triazolobenzodiazepines have produced both anterograde and retrograde amnesia. PAF antagonist (BN 52021) has only produced retrograde amnesia and it has not produced anterograde amnesia. The anterograde amnesia produced by benzodiazepine and triazolobenzodiazepines, has been prevented by benzodiazepine receptor antagonist (flumazenil). It suggests that benzodiazepine- and triazolobenzodiazepines-induced anterograde amnesia may be mediated through benzodiazepine receptors. On the other hand, retrograde amnesia produced by PAF antagonist (BN 52021) and triazolobenzodiazepines has been attenuated by PAF and PAF acetyl hydrolase inhibitors such as cigarette smoke extract (CSE) and phenylmethanesulfonylflouride. It suggests that triazolobenzodiazepine-induced retrograde amnesia may be mediated through blockade of PAF receptors.

A method to cope with the random errors of observed accident rates in regression analysis.

The paper is concerned with linear multiregression analysis on accident rates related to road geometric design elements. Supposing that a data set of accident records and geometric design elements of a certain stretch of a road is given, there are two steps for regression analysis: first, division of the road into a number of segments; and second, application of regression analysis to the set of segments. The main interest of the present paper is the first step. Occurrence of a traffic accident in a road segment is a stochastic event and an observed accident rate in a segment contains a certain magnitude of random error that deteriorates the explanatory power and reliability of the regression analysis. Random errors are required to be appropriately controlled for an effective regression analysis. The first part of the paper discusses how to evaluate a random error contained in an accident rate of a road segment and shows that a random error depends on the number of accidents and vehicle-kilometerage of the segment. It is then shown that random errors of the segment should be as much as possible equal to each other and small enough compared with the accident rate variance based on the discussion of how the random errors affect the efficiency of regression analysis. Several alternative criteria on the random errors for dividing a road into segments are proposed and numerical examples of Tokyo-Kobe Expressway are presented to examine the appropriateness of the alternative criteria. One of them is finally recommended as the most practically useful criterion.