[Innovative technologies and multimodal correction in medical rehabilitation of motor and neuropsychological disturbances due to stroke]. / Innovatsionnye tekhnologii i vozmozhnosti mul'timodal'noi korrektsii postinsul'tnykh dvigatel'nykh i neiropsikhologicheskikh narushenii.

The article presents an overview of innovative technologies based on the methods of sensorimotor retraining of the patient using various types of biofeedback (BFB) as the most promising in the medical rehabilitation (MR) of patients with cerebral stroke (CS). The works of a high level of evidence (RCTs, national and international clinical guidelines, meta-analyses, systematic reviews) of the Medline, Pubmed, PubMed Cochrane Library databases are analyzed, ClinicalTrials.gov. It is emphasized that training with multisensory effects on visual, auditory, vestibular and kinesthetic analyzers have a beneficial effect on cognitive-motor training and retraining, neuropsychological status of the patient and increase the level of motivation to achieve success in the rehabilitation process. The synergy of multimodal effects of digital technologies, BFB, virtual reality, and the brain-computer interface will expand the capabilities and improve the efficiency of MR of after stroke-patients.

[Lifestyle factors and medical activity of patients with COVID-19 treated on an outpatient basis using telemedicine technologies].

The aim of the study was to study the factorial conditionality of the state of health and the features of medical activity (MA) of patients with COVID-19 who were treated on an outpatient basis using telemedicine technologies. MATERIAL AND METHODS: The study of lifestyle factors (LS) and MA was conducted by an anonymous survey of 7,743 patients with COVID-19. The patients' health was assessed based on the study of the course of the underlying disease and the presence of concomitant diseases, which were detected in 24.3% of COVID-19 patients according to the data of copying information from medical records. RESULTS: It was revealed that the prevalence of tobacco smoking was 33.25 cases per 100 respondents, 45.4% of respondents were overweight, 75.6% of patients had a low level of physical activity, 68.2% and 53.8% of patients had low medical literacy and MA, respectively. It is established that the greatest impact on the health status of the patients interviewed was provided by the bio-social activity (Smoking) (h = 0.702; m = 0.0063; p = 0.0022), physical activity (h = 0.624; m = 0.0026; p < 0.001, health behavior (h = 0.527; m = 0.0030; p < 0.001) and health literacy (h = 0.532; m = 0.0028; p < 0.001). CONCLUSION: The studied risk factors affecting the health status of COVID-19 patients, most of which are manageable, should be taken into account when forming therapeutic and preventive measures.

DENTAL STATUS FEATURES IN PATIENTS DURING ANTI-CANCER CHEMOTHERAPY (TRANSCARPATHIAN ANTITUMOR CENTER EXPERIENCE).

One of the most common complications of complex anticancer therapy is the development of various lesions of the oral cavity, including mucositis, which adversely affects the quality of life of the patient, limits the dose of chemotherapy and radiotherapy, and further adversely affects the effectiveness of complex therapy. Objective - to investigate the dental status of patients who are in anticancer chemotherapy and radiotherapy through clinical examination and calculation hygienic indices. During the study, the oral cavity was examined in 130 patients from 2015-2020, during the examination the dental status was registered and complaints were recorded. The dental status of patients on antitumor chemotherapy and radiotherapy by the method of clinical examination and calculation of hygienic indices (CSR (caries: sealed: removed), CPI index, Green Vermilion index, Fedorov-Volodkina index) was studied. A clinical examination of the oral cavity of patients who were on anticancer therapy in a cancer hospital revealed that the patients had poor oral hygiene and needed specialized dental treatment. Burning of the oral mucosa was present in 92.3% of patients, paresthesia - in 97.7%, taste disturbance and xerostomia - in all patients. In 30.0% there was angular cheilitis, in 96.2% bleeding gums, pus from periodontal pockets in - 17.7%, the formation of ulcers of the oral mucosa - 63.9%, mouth opening disorders - in 19.2%. The need for dental care was in 13.1% of patients in the study group. During the year before hospitalization, patients had 0.8±0.4 visits to the dentist per year, rarely used additional personal hygiene products for oral care - in 9.2%. The results indicate the presence of oral problems in 100.0% of patients receiving specialized antitumor chemotherapy and radiotherapy, as well as the presence of a sufficiently high need for specialized dental treatment.

[The role of extracorporeal shock wave therapy in the combined restorative treatment of the patients presenting with myofascial pain syndrome]. / Ékstrakorporal'naia udarno-volnovaia terapiia v kompleksnom vosstanovitel'nom lechenii patsientov s miofastsial'nym bolevym sindromom.

The myofascial pain syndromes (MPS) is ranked among the most frequent clinical manifestations of acute and chronic pain in the lumbar region. The authors of the article undertook the analysis of scientific publications from the Pubmed, Medline, and Scopus databases that appeared during the recent years. The analysis has demonstrate that extracorporeal shock wave therapy (ESWT) can be considered as a method of choice to be used in the framework of the complex programs of the treatment and rehabilitation of the condition of interest. The specific etiopathogenetic features of ESWT are considered in terms of the contemporary views with special reference to their influence on the choice of the treatment strategies and concrete methods for the treatment of the myofascial pain syndromes. It is shown that extracorporeal shock wave therapy makes it possible to enhance the blood flow and circulation and increase the permeability of cell membranes thereby facilitating the activation of the regenerative processes in the structural elements of the vertebral-motor segment undergoing the dystrophic changes. Moreover, ESWT produces the anti-inflammatory effects and causes muscle relaxation. There is strong evidence of the possibility to use such modern modalities of manual needs tlomethods of ESWT and manual therapy in patients with MFBS that requires further research. The expected effects of the combined application of extracorporeal shock wave therapy and manual therapy for the treatment of the patients presenting with myofascial pain syndrome remain to be verified in the further studies.

[The Medical Social Efficiency of Rehabilitation of Patients Having Cerebral Stroke in Ambulatory Conditions].

The article substantiates efficiency of medical social rehabilitation activities in out-patient conditions on the basis of study of health conditions, life-style and medical care organization of patients with ischemic stroke. The obtained data demonstrated a higher efficiency of complex rehabilitation therapy. The efficient application of possibilities of out-patient polyclinic institution increases the level of physiological, psychological and social adaptation of patients.

[The depressive disorders during the early rehabilitation period following preceding ischemic stroke: the possibilities for the application of the enhanced external counterpulsation method].

The authors present arguments in favour of the necessity to reveal and treat the co-morbid conditions with special reference to depressive disorders in the patients during the early rehabilitation period following preceding ischemic stroke. They demonstrate the importance of the application of non-medicamentous therapy in combination with the standard medicamental treatment. Special emphasis is placed on the analysis of the data obtained during evaluation of the effectiveness of combined therapy with the use of the enhanced external counterpulsation method in the early post-stroke period. It is concluded that the early diagnostics and timely correction of anxio-depressive conditions promotes the efficiency of rehabilitative measures and improves the quality of life of the patients with such disorders.

[The enhanced external counterpulsation as a method of non-invasive auxiliary blood circulation used for the combined rehabilitative treatment of the patients surviving after ischemic stroke (a review)].

The present review of the foreign and domestic literature is concerned with the application of the method of enhanced external counterpulsation (EECP) therapy for the treatment of the patients presenting with various diseases. It is shown that many recent publications report extensive investigations of the clinical and neurophysiological aspects of the application of this method for the combined regenerative treatment of the patients surviving after ischemic stroke (IS). The possibility of the influence of EECP therapy on the system of regulation of the cerebral blood flow, the formation of collateral circulation in the ischemic tissue, and the cellular-humoral mechanisms are considered. It is concluded that the introduction of enhanced external counterpulsation therapy into the program of the combined rehabilitative treatment on an individual basis for the patients surviving after ischemic stroke is pathogenetically substantiated as promoting regression of clinical, neurological, and neuropsychological disorders.

[The use of botulinum toxin type A in symptomatic therapy and medical rehabilitation of patients with multiple sclerosis]. / Primenenie botulinicheskogo toksina tipa A v simptomaticheskoi terapii i meditsinskoi reabilitatsii patsientov s rasseyannym sklerozom.

The review of the current state of the problem of symptomatic therapy and medical rehabilitation (MR) of patients with multiple sclerosis (MS) is presented. The search was conducted in the databases Medline, Web of Science, PubMed and Scopus. Information is given about the most common symptoms of MS, among which sensory and motor disorders, bladder dysfunction, and pain have the greatest impact on the quality of life of patients, their functioning and independence in everyday life. The clinical characteristics of spasticity syndrome in MS and its relationship with quality of life indicators are considered. The features of the use of botulinum therapy (BT) in MS are considered. A high level of effectiveness of the use of BT in the treatment of neurogenic hyperactivity of detrusor and neurogenic bladder (the level of persuasiveness of recommendation A) and spasticity (the level of persuasiveness of recommendation B) is shown. Symptomatic treatment of MS and MR with the use of multidisciplinary programs helps to reduce disability, improve the quality of life of patients. When choosing symptomatic treatment and MR methods, it is customary to focus on the needs of patients.

[Effectiveness of rehabilitation with virtual reality and biofeedback in recovery of hand function after stroke]. / Effektivnost' reabilitatsii s virtual'noi real'nost'yu i biologicheskoi obratnoi svyaz'yu v vosstanovlenii funktsii kisti posle insul'ta.

OBJECTIVE: To evaluate the effectiveness and safety of the rehabilitation glove (RG) with virtual reality (VR) and biofeedback (BFB) on recovery of the hand function in patients during the late recovery period after first hemispheric ischemic stroke (IS). MATERIAL AND METHODS: The study was randomized and controlled. One hundred and six patients (age 58.8±4.3 years, time after stroke onset - 8.7±2.1 months) were included in the final analysis. The intervention group (n=56) received rehabilitation with RG and VR. The control group (n=50) received individualized physical therapy. The primary end points were a change in the Fugl-Meyer scale score (FMA-UE), in the Action Research Arm Test (ARAT), and in the nine holes peg test (NHPT). Secondary end points included changes in MRCS, MAS, MoCA, HADS, modified Barthel index (MBI) and quality of life (EQ-5D-5L). RESULTS: Improvement of the motor function in the intervention group on FMA-UE scale (an increase of ≥7 points in sections A-D) was observed in 46.4% of patients, on ARAT (an increase of ≥5 points) in 53.6% of patients. There was a significant decrease in time from 36.8±6.3 sec. to 22.0±3.9 sec. on NHPT. A negative correlation was observed between the average ARAT score and anxiety (r=-0.7; p<0.05) and depression (r=-0.67; p<0.05). There was also a significant increase in EQ-5D-5L (VAS) by the end of rehabilitation in both groups with better scores in the intervention group (p=0.03). CONCLUSION: Rehabilitation based on VR, RG, and BFB is effective in the rehabilitation of dexterous hand function in patients with first hemispheric IS.

[Multimodal technology in the correction of post-stroke motor disorders]. / Mul'timodal'naya tekhnologiya korrektsii postinsul'tnykh dvigatel'nykh narushenii.

OBJECTIVE: To evaluate the effectiveness of a comprehensive rehabilitation program with the inclusion of programmable FES and BFB-stabilometric training in patients with post-stroke statolocomotor disorders in the late recovery period of ischemic stroke (IS). MATERIAL AND METHODS: The study included 120 patients in the late recovery period of IS, 57 women and 63 men, average age 58.4±6.4 years. The duration of the stroke was 228.59±31.9 days. The main group (MG) included 30 patients who underwent FES and BFB-stabilometric training. Comparison group 1 (CG1, n=30) received computer stabilometric training with BFB. Comparison group 2 (CG2, n=30) received FES. The control group (CG3, n=30) received a standard rehabilitation program. MR programs were carried out for all patients in the amount of 15 procedures every other day (5 weeks). RESULTS: The complex of rehabilitation measures with the inclusion of FES and BFB-stabilometric training significantly improve the function of walking in the form of restoration of the motor stereotype by the 5th week of the study, which was confirmed by neurological scales and stabilometry data. CONCLUSIONS: The inclusion of FES and BFB-stabilometric training methods in the rehabilitation process leads to earlier motor adaptation of the patient, restoration of impaired balance function and quality of life, which is associated with an increase in plastic and associative processes of the brain.

[The effect of rehabilitation with sensory glove and virtual reality on concentration of brain-derived neurotrophic factor and event related potential P300 in the early rehabilitation period after ischemic stroke]. / Vliyanie reabilitatsii s sensornoi perchatkoi i virtual'noi real'nost'yu na dinamiku neirotroficheskogo faktora golovnogo mozga i kognitivnykh vyzvannykh potentsialov P300 v rannem vosstanovitel'nom periode ishemicheskogo insul'ta.

OBJECTIVE: To study the effect of rehabilitation with sensory glove (SG) and virtual reality (VR) on changes in brain-derived neurotrophic factor (BDNF) concentration and amplitude and latency of event related potential (ERP) P300 in the early rehabilitation period after hemispheric ischemic stroke (IS). MATERIAL AND METHODS: Ninety patients (mean age 58.0±9.7 years, time after stroke onset - 3.8±1.6 months) were randomized into intervention (IG) and control (CG) groups. Patients in both groups received 15 sessions of rehabilitation (30 min, 3 times a week). Patients in the IG (n=46) received rehabilitation with SG and VR. Patients in CG (n=44) received individualized physical therapy. The end points were a change in the MMSE, MoCA, 10-word Luria test, subtests of Wechsler Adult Intelligence Scale IV (WAIS IV) test, amplitude and latency of P300, and BDNF concentration on admission and at the end of rehabilitation. RESULTS: There was an improvement on MoCA test (p=0.049) and working memory index of the WAIS IV test (p=0.045) iIn the IG after completing rehabilitation the improvement on MoCA test (p=0.049) and working memory index of the WAIS IV test (p=0.045) was observed. There was aA trend tendency towards an significant increase on MMSE (p=0.093) and 10-word Luria test (p=0.052) was observed. In CG, an improvement with a trend towards significant differences (p≤0.12) on all above mentioned tests was also observednoted. In both groups there were no significant changes in the amplitude or latency of P300. Concentration of BDNF increased significantly in the IG (p=0.042), while in the CG a tendency (p=0.064) was observed (p=0.064). By the end of rehabilitation, the delta between groups in the increase of BDNF concentration was 17.9%, p=0.072. In both groups, there was a correlation between scores on cognitive tests and BDNF concentration. Absence/presence of cognitive disorders was not associated with initial or final BDNF concentrations or delta between groups. RESULTS: In the IG after completing rehabilitation the improvement on MoCA test (p=0.049) and working memory index of the WAIS IV test (p=0.045) was observed. There was a tendency towards significant increase on MMSE (p=0.093) and 10 word Luria test (p=0.052). In CG an improvement with a trend towards significant differences (p≤0.12) on all above mentioned tests was also observed. In both groups there were no significant changes in the amplitude or latency of P300. Concentration of BDNF increased significantly in the IG (p=0.042), while in the CG a tendency was observed (p=0.064). By the end of rehabilitation, the delta between groups in the increase of BDNF concentration was 17.9%, p=0.072. In both groups there was a correlation between scores on cognitive tests and BDNF concentration. Absence/presence of cognitive disorders was not associated with initial or final BDNF concentration or delta between groups. CONCLUSION: VR and SG in the early rehabilitation period after IS is are as equally effective as rehabilitation with individualized physical therapy (aerobic training) in increasing BDNF concentration and in improvement on cognitive tests.

[Effectiveness of correction of post-stroke motor disorders using the methods of functional electrostimulation and BFB-stabilometric postural control]. / Éffektivnost' korrektsii postinsul'tnykh dvigatel'nykh narushenii s primeneniem metodov funktsional'noi élektrostimuliatsii i BOS-stabilometricheskogo postural'nogo kontrolia.

AIM: To evaluate the effectiveness of complex rehabilitation with the inclusion of functional electrostimulation (FES) and BFB-stabilometric postural control in patients with post-stroke motor disorders in the late recovery period. MATERIAL AND METHODS: Sixty-seven patients in the late recovery period of stroke, 31 women and 36 men, mean age 58.4±6.4 years, were studied. The duration of stroke was 228.59±31.9 days. Ischemic stroke was in 71.9% of patients, hemorrhagic stroke in 28.1%. The first group included 42 patients with stroke, who, in addition to standard treatment regimen, had FES and BFB stabilometric training. The second group comprised 25 patients with stroke, the rehabilitation of which did not include above-mentioned methods. RESULTS AND CONCLUSION: A complex of rehabilitation measures with the inclusion of FES and BFB stabilometric postural training made it possible to significantly improve the function of walking in the form of restoration of the motor stereotype. The clinical effect was traced 3 weeks after the beginning of rehabilitation, reaching a maximum by the 5th week. Inclusion of BFB-based methods in the rehabilitation process leads to earlier motor and social adaptation of the patient, restoration of the disturbed equilibrium function, which is associated with an increase in the plastic and associative processes of the brain.

[Modern aspects of the pathophysiology of walking disorders and their rehabilitation in post-stroke patients]. / Sovremennye aspekty patofiziologii narushenii khod'by u patsientov posle insul'ta i osobennosti ikh reabilitatsii.

The problem of rehabilitation of post-stroke patients with motor deficit remains relevant with growing prevalence of disability and decreasing mortality, despite all measures aimed at stroke prevention and morbidity reduction. One of the most common consequences of stroke is gait impairment as a result of spastic paresis of the lower limb (decreased gait velocity, shortened step, excessive loading of intact limb etc.), which leads to significant maladaptation, increased risk of falls, decrease in quality of life. The article presents a detailed review of motor action in normal and pathologic conditions, analysis of neuronal structures involved into a movement act in healthy individuals and in stroke patients, current aspects of gait pathophysiology, characteristics of post-stroke gait (speed and asymmetry of gain, balance control impairment). A separate paragraph is devoted to gait recovery after stroke with analysis of existing and developing strategies of rehabilitation, aimed at the improvement of vertical posture, balance control and movement, condition, tone and functioning of skeletal muscles. Authors also analyze new research information on the efficacy of botulinum toxin preparations and programs of Guided Self-Rehabilitation Contracts (GSC), present the results of clinical trials demonstrating the efficacy of combination of these two methods.

Use of the new levodopa agent Stalevo (levodopa/carbidopa/entacapone) in the treatment of Parkinson's disease in out-patient clinical practice (the START-M open trial).

Despite the significant symptomatic effects of levodopa, stable 24-h treatment responses are in the vast majority of patients replaced 2-3 years from the start of treatment by oscillations in motor symptoms (fluctuation, dyskinesia), amelioration of which requires addition of constant (physiological) stimulation of postsynaptic dopamine receptors. To some extent this is provided by Stalevo, which contains levodopa and two enzyme inhibitors: the DDC inhibitor carbidopa and the COMT inhibitor entacapone. The results obtained in the present study demonstrated the advantages of Stalevo over traditional agents in patients with the "wearing off" and "on-off" phenomena.

[Treatment of a spastic increase of muscle tone in multiple sclerosis with botulinum toxin]. / Korrektsiia spasticheskogo povysheniia myshechnogo tonusa pri rasseiannom skleroze s ispol'zovaniem botulinoterapii.

The article presents data of the reviews, consensus and recommendations on the use of botulinum toxin type A (BTA) in multiple sclerosis (MS) patients with spasticity syndrome. It presents the results of randomized clinical trials that confirm the efficacy and favorable safety profile of dysport in treatment of MS patients. The complex approach to spasticity therapy and rehabilitation in MS is discussed.

[The efficacy of semax in the tretament of patients at different stages of ischemic stroke]. / Éffektivnost' semaksa pri lechenii bol'nykh na raznykh stadiiakh ishemicheskogo insul'ta.

AIM: To evaluate the efficacy of semax and timing of rehabilitation on the dynamics of plasma BDNF levels, motor performance, and Barthel index score in patients after ischemic stroke (IS). MATERIAL AND METHODS: One hundred and ten patients after IS (43 men, 67 women, mean age 58.0±9.7, Ме 63 years) were examined. All patients were divided into early (89±9 days) and late (214±22 days) rehabilitation groups. Each group was subdivided into semax+ and semax- subgroups. Standard regimen of semax included 2 courses (6000 mcg/day) for 10 days with 20 day interval. Plasma BDNF levels, motor performance on the British Medical Research Council scale and Barthel index were assessed in all groups. RESULTS: Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period. In semax- subgroups high BDNF plasma levels were positively correlated with early rehabilitation. Administration of semax and high BDNF levels accelerated the improvement and ameliorated the final outcome of Barthel score index. There was a positive correlation between BDNF plasma levels and Barthel score, as well as a correlation between early rehabilitation and motor performance improvement. The correlation between BDNF plasma levels and Barthel score was modified by the timing of rehabilitation. CONCLUSION: Early rehabilitation and administration of semax increase BDNF plasma level, speed functional recovery, and improve motor performance.

[Influence chronopharmacology therapy methionine (melaxen) on the dynamics of sleep disturbance, cognitive and emotional disorders, brain-derived neurotrophic factor (BDNF) in patients with cerebral stroke in the early and late recovery periods]. / Vliianie khronofarmakologicheskoi terapii melatoninom (melaksen) na dinamiku narushenii sna, kognitivnykh i émotsional'nykh rasstroistv, neirotroficheskogo faktora mozga u patsientov v vosstanovitel'nom periode insul'ta.

AIM: To study the efficacy of melaxen on the dynamics of sleep disturbance, cognitive and emotional disorders, BDNF and the level of secretion of melatonin (6-SOMT) in patients with stroke in the early and late recovery phase. MATERIAL AND METHODS: One hundred and ten patients in the rehabilitation period of stroke (mean age of 58.4±6.4 years), including 60 patients in the early recovery phase (group 1) and 50 patients in the late phase (group 2), were studied. Patients received melaxen in dose of 3 mg/day for 3 months along with standard treatment. The efficacy of therapy was assessed by the dynamics of sleep disorders, emotional status, dynamics of serum BDNF levels, 6-SOMT concentration in the urine. RESULTS AND CONCLUSION: The study has demonstrated the high efficacy of melaxen in the rehabilitation of patients in early and late recovery phase of stroke. The drug significantly increased the BDNF level that correlated with improved sleep, emotional status, quality of life of patients.

[An effect of education and health literacy on the efficacy of rehabilitation of post-stroke patients]. / Vliianie urovnia obrazovaniia i meditsinskoi gramotnosti na éffektivnost' reabilitatsionnykh meropriiatii u bol'nykh, perenesshikh insul't.

AIM: To study an effect of education, health literacy and adherence to treatment on the efficacy of rehabilitation of post-stroke patients. MATERIAL AND METHODS: The study included 1317 post-stroke patients. Information on education, health literacy and implementation of complex rehabilitation was obtained using anonymous survey. The duration of follow-up was 18 month. Patients were examined at baseline and after 6, 12 and 18 month. RESULTS: A significant correlation between adherence to rehabilitation treatment and the level of health literacy and education was shown. An analysis of the efficacy of comprehensive rehabilitation demonstrated the statistically significant prevalence of patients with positive dynamics of neurological disorders among those who had fully completed the program. CONCLUSION: Differentiated and individual personal selection of rehabilitation programs improves their efficacy.

[Conversion ratio between different botulinum neuroprotein product in neurological practice]. / Sootnoshenie edinits deistviia razlichnykh preparatov botulinicheskogo neiroproteina pri ispol'zovanii v nevrologicheskoi praktike.

Despite nearly 30 years of experience in the application of botulinum toxin type A (BTA) in clinical practice, many fundamental questions of therapy remain valid. There are 5 botulinum toxin type A used for neurological indications in the Russian Federation in 2017. They contain different number of active neuroprotein (150 kDa) in a therapeutic dose of the drug that may have a potential impact on the efficacy and duration of action. The current SmPC of each BTA stated that the unit of activity is unique and can not be compared with any other BTA. In scientific publications one can find many details concerning the equivalence doses of onabotulinumtoxin A (botox) and abobotulinumtoxin A (dysport) and the ratio of units varies from 1:1 to 1:11. However, according to clinical guidelines, systematic reviews and high quality research evidence of recent years, the ratio of units of abobotulinumtoxin A (dysport) and onabotulinumtoxin A (botox) is 3(2,5):1. Use of a fixed ratio of units is possible only when switching from one drug to another or in case of limiting access to specific drug. Botulinum toxin type A is the first line of therapy in the treatment of several neurological diseases. The most commonly used drugs of botulinum toxin type A (botox, dysport, xeomin) have a significant evidence base that confirms their efficacy and optimal safety profile. The main difference between botulinum toxin type A is their potential activity of action, i.e., activity units and total therapeutic dose.