Detalhe da pesquisa
1.
A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers.
Invest New Drugs
; 40(4): 747-755, 2022 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35404015
2.
Pharmacokinetics, distribution, and disposition of esaxerenone, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist, in rats and monkeys.
Xenobiotica
; 47(12): 1090-1103, 2017 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-27866463
3.
Physiologically based pharmacokinetic modeling to predict the clinical effect of azole antifungal agents as CYP3A inhibitors on azelnidipine pharmacokinetics.
Drug Metab Pharmacokinet
; 55: 101000, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38458122
4.
Edoxaban Exposure in Patients With Atrial Fibrillation and Estimated Creatinine Clearance Exceeding 100 mL/min.
Clin Pharmacol Drug Dev
; 11(5): 666-674, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34877813
5.
Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective.
Clin Pharmacol Ther
; 112(4): 770-781, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34862964
6.
Novel binding mode of the acidic CYP2D6 substrates pactimibe and its metabolite R-125528.
Drug Metab Dispos
; 36(9): 1938-43, 2008 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-18524873
7.
Effects of ketoconazole and quinidine on pharmacokinetics of pactimibe and its plasma metabolite, R-125528, in humans.
Drug Metab Dispos
; 36(8): 1505-11, 2008 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-18448569
8.
CYP2D6-Mediated metabolism of a novel acyl coenzyme A:cholesterol acyltransferase inhibitor, pactimibe, and its unique plasma metabolite, R-125528.
Drug Metab Dispos
; 36(3): 529-34, 2008 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-18056254
9.
Molecular imaging of T cell co-regulator factor B7-H3 with 89Zr-DS-5573a.
Theranostics
; 8(15): 4199-4209, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-30128047
10.
Molecular Simulation of Receptor Occupancy and Tumor Penetration of an Antibody and Smaller Scaffolds: Application to Molecular Imaging.
Mol Imaging Biol
; 19(5): 656-664, 2017 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28213834
11.
Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with 89Zr-DS-8895a.
J Nucl Med
; 57(6): 974-80, 2016 06.
Artigo
Inglês
| MEDLINE | ID: mdl-26940768
12.
In Vitro and In Vivo Evaluation of 89Zr-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy.
Theranostics
; 6(12): 2225-2234, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27924159
13.
Predictive Modeling of Drug Response in Non-Hodgkin's Lymphoma.
PLoS One
; 10(6): e0129433, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26061425
14.
Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer.
J Clin Oncol
; 33(24): 2609-16, 2015 Aug 20.
Artigo
Inglês
| MEDLINE | ID: mdl-26124477
15.
Regression of inflammation in atherosclerosis by the LXR agonist R211945: a noninvasive assessment and comparison with atorvastatin.
JACC Cardiovasc Imaging
; 5(8): 819-28, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22897996