Detalhe da pesquisa
1.
Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes.
Arterioscler Thromb Vasc Biol
; 41(4): 1309-1318, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33626909
2.
Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines.
J Neuroinflammation
; 16(1): 257, 2019 Dec 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31810478
3.
Safety of Anti-Reelin Therapeutic Approaches for Chronic Inflammatory Diseases.
Cells
; 13(7)2024 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-38607022
4.
Circulating Reelin promotes inflammation and modulates disease activity in acute and long COVID-19 cases.
Front Immunol
; 14: 1185748, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37441066
5.
Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.
J Biol Chem
; 285(49): 38042-52, 2010 Dec 03.
Artigo
Inglês
| MEDLINE | ID: mdl-20921220
6.
Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis.
Sci Immunol
; 6(62)2021 08 27.
Artigo
Inglês
| MEDLINE | ID: mdl-34452924
7.
Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes.
Sci Transl Med
; 12(556)2020 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32801146
8.
NGP 555, a γ-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses.
Alzheimers Dement (N Y)
; 5: 458-467, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31921961
9.
NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aß42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents.
Alzheimers Dement (N Y)
; 3(1): 65-73, 2017 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-28497107
10.
Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.
Biochem Pharmacol
; 69(4): 689-98, 2005 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-15670587
11.
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Neuron
; 67(5): 769-80, 2010 Sep 09.
Artigo
Inglês
| MEDLINE | ID: mdl-20826309
12.
NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease.
J Clin Invest
; 119(12): 3692-702, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19907078
13.
Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.
J Biol Chem
; 284(6): 3793-803, 2009 Feb 06.
Artigo
Inglês
| MEDLINE | ID: mdl-19074428
14.
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
J Biol Chem
; 284(3): 1373-84, 2009 Jan 16.
Artigo
Inglês
| MEDLINE | ID: mdl-19028695
15.
Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism.
Mol Neurodegener
; 2: 4, 2007 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-17288597
16.
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.
J Biol Chem
; 281(43): 32240-53, 2006 Oct 27.
Artigo
Inglês
| MEDLINE | ID: mdl-16945923