RESUMO
A nanosecond-millisecond combined pulse laser (CPL) drilling method was proposed for drilling alumina ceramic. The total energy consumption of the CPL drilling was 1/7 of that of a conventional millisecond laser, and the drilling quality was better. The simulation results demonstrated that, due to the nonuniform reflection of the millisecond laser in the keyhole, the ellipse keyhole ablated by the off-axis incident nanosecond pulses had no effect on the circularity of the through hole. In addition, the multireflection of the laser in the keyhole enhanced the absorption, so the keyhole ablated by the nanosecond pulses could be used as a target for limiting the absorption of the subsequent millisecond pulses. In this context, the keyhole could be used to reduce the hole diameter if the subsequent millisecond laser had a bigger spot size, and this CPL drilling method could be used as an effective group hole drilling method.
RESUMO
Porphyrins are functional elements of important biomolecules, whose assemblies play a central role in fundamental processes such as electron transfer, oxygen transport, enzymatic catalysis, and light harvesting. Here we report an approach to formation of porphyrin supermolecules, a particular type of nanoparticles with unusually strong noncovalent intermolecular interactions. Key differences between the supermolecules and noncovalent nanostructures described earlier are as follows. (1) Supermolecules consist of molecules of the same type without side groups promoting the self-assembly and without any spacers; no surfactant or catalyst to assist the process is needed. (2) They exhibit unusual photophysical properties and remain stable even in organic solvents. Their formation occurs under specially selected conditions at the air-water interface at room temperature. Following this route, we have formed supermolecules of magnesium porphine, a functional element of chlorophyll. The properties of these supermolecules are markedly different from those of the constituent molecules. For example, in contrast to the pink color of the monomer solution, solutions of supermolecules are transparent for visible light and absorb in the ultraviolet and near-infrared regions. We also present atomic force microscopy visualization of the porphyrin two-dimensional nanoaggregates forming at the air-water interface that were predicted in our previous works. This approach offers a guideline for the discovery of new supermolecules, including complex biological ones, and the formation of supermolecular materials with novel properties.
RESUMO
Nano- and microstructures based on ferrimagnets can demonstrate high efficiency and dynamics of current-induced magnetization switching combined with high stability of spin textures such as bubble domains and skyrmions, which are of practical importance for the development of spintronics and spin-orbitronics. This set of features is usually associated with magnetic momentum or angular momentum compensation states. Here, we experimentally show that the compensation state can be realized locally using nonuniform Joule heating. This effect is observed in the variable-width current guide made of the ferrimagnetic W/Co76Tb24/Ru thin films, where the position of a region heated to the compensation temperature depends linearly on the current pulse amplitude. This approach makes it possible to observe the simultaneous coexistence of Co-dominant and Tb-dominant regions, where current pulses induce spin-orbit torques in opposite directions, leading to local magnetization switching. It is found that the position of a Néel domain wall constraining the switched region lies in the vicinity of the coordinate corresponding to the compensation point but does not coincide with it due to high mobility under the action of spin current. Our findings open an alternative approach for engineering of ferrimagnetic nanodevices with advanced properties for future applications in spintronics, spin-orbitronics, and nanoelectronics.
RESUMO
The fabrication approach of a magnonic crystal with a step-like hysteresis behavior based on a uniform non-monotonous iron layer made by shadow deposition on a preconfigured substrate is reported. The origin of the step-like hysteresis loop behavior is studied with local and integral magnetometry methods, including First-Order Reversal Curves (FORC) diagram analysis, accompanied with magnetic microstructure dynamics measurements. The results are validated with macroscopic magnetic properties and micromagnetic simulations using the intrinsic switching field distribution model. The proposed fabrication method can be used to produce magnonic structures with the controllable hysteresis plateau region's field position and width that can be used to control the magnonic crystal's band structure by changing of an external magnetic field.
RESUMO
An experimental study of the phenomenon of electric current influence on the value and orientation of the exchange bias field (HEB) in the Pt/Co/NiO structure is carried out. Depending on the direction of the magnetization in a ferromagnet (FM) layer and the current pulse amplitude, the value of the HEB field can be changed repeatedly in the range of ±7.5 mT. A few experiments are performed to separate the contributions from two current-induced effects: (i) an injection of the spin current into an antiferromagnet layer (AFM) and (ii) Joule heating. As a result, we conclude that the modification in the HEB field during current pulse transmission in the Pt/Co/NiO structure is due to heating and the low value of Néel temperature (TN = 162 °C). This fact explains the absence of the exchange bias effect on the spin-orbit torque (SOT)-assisted magnetization switching. The most striking observation to emerge from the experimental data analysis is that depending on the initial spin configuration of the domain structure in the FM layer and the current pulse amplitude, the exchange bias can be changed locally. This opens up prospects for creating exchange-coupled FM/AFM structures with dynamically tuned parameters of the exchange bias, which can be used for the development of magnetic memory, neuromorphic, and logic devices based on magnetic nanosystems.
RESUMO
BACKGROUND: Non-vitamin K oral anticoagulants (NOACs) are commonly used for prophylaxis of venous thromboembolism (VTE) in orthopedic patients. Despite known safety and high potency of NOACs, potential interactions of NOACs with genetic polymorphisms are poorly understood. Dabigatran etexilate is one of the most commonly prescribed direct thrombin inhibitors for the prevention of VTE. The objectives of this study were to assess the effect of ABCB1 (rs1045642 and rs4148738) and CES1 (rs2244613) polymorphisms on dabigatran pharmacokinetics in patients after total knee arthroplasty. PATIENTS AND METHODS: A total of 60 patients, aged 37-81 years, who underwent surgery for knee replacement have been included in the study. VTE prophylaxis was conducted via administration of dabigatran etexilate 220 mg once daily. Genotyping for carrier state of polymorphic variants such as rs1045642 and rs4148738 of the ABCB1 gene and rs2244613 of the CES1 gene was carried out using real-time polymerase chain reaction (PCR). We also measured the peak and trough concentrations of plasma dabigatran by using high-performance liquid chromatography (HPLC). RESULTS: Our study revealed that TT genotype of rs1045642 polymorphism of the ABCB1 gene was associated with higher dabigatran equilibrium peak concentrations and the higher risk of bleeding than the presence of CC genotype (p<0.008). There was no statistically significant genotype-dependent difference in the trough concentrations between rs1045642 and rs4148738 of the ABCB1 gene and rs2244613 of the CES1 gene. CONCLUSION: Our findings indicate that the polymorphisms of ABCB1 rs1045642 may have a prominent contribution to the safety of dabigatran in patients after knee surgery. Moreover, TT genotype may be associated with the higher risk of hemorrhagic complications in this population. There were no influence of polymorphism of ABCB1 rs4148738 and CES1 rs2244613 on dabigatran peak and through concentrations. Larger studies are needed to confirm our observations.