Distant metastasis of rectal adenocarcinoma in a temporary tracheostoma.

BACKGROUND: The temporary tracheostoma's metastases of head and neck cancer had already been reported in the literature. So far, they had been considered as regional dissemination of the malignant disease. We report a case of temporary tracheostoma's metastasis of carcinoma from non-head-and-neck primary site, what has not been reported in the literature, yet. Therefore, it is the first reported case of the systemic dissemination of malignant tumour into temporary tracheostoma. CASE REPORT: Fifty-four-year-old female patient, previously treated for a rectal adenocarcinoma, reported in our office with exophytic pink tissue masses around the temporary tracheostoma. The biopsy and immunohistochemistry findings were consistent with temporary tracheostoma's metastasis of the rectal adenocarcinoma. The patient received palliative radiotherapy and died of systemic progression of the disease. CONCLUSIONS: The patients with history of primary cancer of any origin and exophytic proliferating changes around the tracheostoma require an appropriate diagnostic work-up including a biopsy. The type of treatment depends on the extent of the disease, previous therapy and general condition of the patient.

Laryngeal Myxoglobulosis: A Rare Histologic Variant of Mucocele. The First Reported Case.

Myxoglobulosis is a rare histologic variant of mucocele that is characterized by transformation of mucin into eosinophilic globules. The globules frequently demonstrate a lamellar pattern and are surrounded by an inflammatory cell infiltrate. Myxoglobulosis has not yet been described in laryngeal mucosa. A 62 year old man presented for a check-up with hoarseness of 2 months duration. He was a current smoker and reported a 40 year habit. An asymmetrical swelling along the length of both vocal cords was consistent with a clinical diagnosis of Reinke's edema. The histopathologic examination demonstrated bilateral pseudocyst formation within Reinke's space. Extravasated mucin was present in the form of eosinophilic globules that filled the left Reinke's space almost entirely and were also seen on the right side. The pseudocyst, mucinous globules, and accompanying inflammatory cells were characteristic of myxoglobulosis. The sequelae of nicotine abuse, including inflammation, increased mucous secretion, and a rasping cough, are considered to be the main etiological factors of laryngeal myxoglobulosis. The patient had no evidence of voice disorder at 18 month follow-up. This case report contributes to the recognition of an exceptionally rare histologic variant of laryngeal mucocele.