RESUMO
Demographic changes in our society will lead to an increasing proportion of elderly people. Age-associated multimorbidity often results in polypharmacy and elevates the risk of adverse drug reactions. Decisive alterations in pharmacokinetics and pharmacodynamics are detectable in old age, primarily a decrease in total body water, an altered ratio of muscle mass to fatty tissue, and decreased renal function. Changes in gastrointestinal transit, plasma protein binding, hepatic drug metabolism, and an increased susceptibility to drug-induced cognitive decompensation have also been reported. All these alterations should be considered in geriatric dermatotherapy to minimize drug-related complications caused by over- or underdosage and drug interactions.
Assuntos
Fármacos Dermatológicos/efeitos adversos , Fármacos Dermatológicos/farmacocinética , Fatores Etários , Idoso , Fármacos Dermatológicos/uso terapêutico , Relação Dose-Resposta a Droga , Humanos , Taxa de Depuração Metabólica/fisiologia , Fatores de RiscoAssuntos
Anticorpos Monoclonais/efeitos adversos , Carcinoma de Célula de Merkel/tratamento farmacológico , Carcinoma de Célula de Merkel/secundário , Trombocitopenia/induzido quimicamente , Idoso , Anticorpos Monoclonais/uso terapêutico , Anticorpos Monoclonais Humanizados/efeitos adversos , Anticorpos Monoclonais Humanizados/uso terapêutico , Carcinoma de Célula de Merkel/patologia , Evolução Fatal , Humanos , Masculino , Púrpura Trombocitopênica Idiopática/induzido quimicamenteAssuntos
Carcinoma Basocelular/patologia , Dermoscopia/métodos , Neoplasias de Cabeça e Pescoço/patologia , Neoplasias do Sistema Nervoso Periférico/patologia , Neoplasias Cutâneas/patologia , Idoso de 80 Anos ou mais , Carcinoma Basocelular/terapia , Diagnóstico Diferencial , Feminino , Avaliação Geriátrica , Humanos , Masculino , Invasividade Neoplásica , Neoplasias do Sistema Nervoso Periférico/terapia , Neoplasias Cutâneas/terapiaRESUMO
Clinically, pyoderma gangrenosum (PG) is characterized by a rapidly progressive, painful cutaneous ulcer with an irregular, violaceous and undermined border. PG occurs most frequently on the lower extremities and the trunk of middle-aged individuals. The face is only very rarely affected. We present an 89- and a 90-year-old patient, who developed a facial ulcer consistent with PG.
RESUMO
OBJECTIVE: To study adipokines as a potential link between obesity and male subfertility. DESIGN: Cross-sectional study of subjects stratified into subgroups according to body mass index (BMI): normal-weight (18.50-24.99 kg/m(2)), overweight (25-29.99 kg/m(2)), and obese (>30 kg/m(2)). SETTING: Leipzig, Germany from 2007 to 2011. PATIENT(S): Ninety-six male volunteers without spermatogenesis-associated diseases. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Semen parameters, reproductive hormones in serum, and leptin, adiponectin, resistin, chemerin, progranulin, vaspin, and visfatin concentrations in serum and seminal plasma. RESULT(S): All measured adipokines were detectable in human seminal plasma. The levels of progranulin, visfatin, and vaspin were statistically significantly higher in seminal plasma than in serum. An increase in body weight was associated with decreased levels of seminal plasma progranulin. Additionally, overweight/obese men had statistically significantly lower progranulin levels in seminal plasma than normal weight men. Adiponectin and progranulin concentrations in seminal plasma statistically significantly positively correlated with sperm concentration, sperm count, and total normomorphic spermatozoa. CONCLUSION(S): Adipokines are differently regulated in human male reproductive tract compared with the peripheral blood, and they could influence sperm functionality.