Detalhe da pesquisa
1.
Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells.
Nat Immunol
; 19(1): 29-40, 2018 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-29242539
2.
Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE.
J Biol Chem
; 291(7): 3520-30, 2016 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-26663084
3.
Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines.
Mol Pharm
; 13(3): 720-8, 2016 Mar 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26824142
4.
Fatty acid synthase is required for mammary gland development and milk production during lactation.
Am J Physiol Endocrinol Metab
; 306(10): E1132-43, 2014 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24668799
5.
Inhibition of the thioesterase activity of human fatty acid synthase by 1,4- and 9,10-diones.
Chem Pharm Bull (Tokyo)
; 62(9): 933-6, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-25177021
6.
Pyruvate Dehydrogenase Inhibition Leads to Decreased Glycolysis, Increased Reliance on Gluconeogenesis and Alternative Sources of Acetyl-CoA in Acute Myeloid Leukemia.
Cancers (Basel)
; 15(2)2023 Jan 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36672433
7.
Polyunsaturated fatty acid metabolism in prostate cancer.
Cancer Metastasis Rev
; 30(3-4): 295-309, 2011 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-22015690
8.
Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat.
Nat Struct Mol Biol
; 14(8): 704-9, 2007 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-17618296
9.
Role of extracellular vesicles secretion in paclitaxel resistance of prostate cancer cells.
Cancer Drug Resist
; 5(3): 612-624, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36176762
10.
Metabolomic credentialing of murine carcinogen-induced urothelial cancer.
Sci Rep
; 11(1): 22085, 2021 11 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34764423
11.
Fatty acid synthase activity in tumor cells.
Subcell Biochem
; 49: 169-94, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18751912
12.
Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.
Cancer Res
; 67(3): 1262-9, 2007 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17283163
13.
Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library.
Cancer Res
; 67(18): 8791-9, 2007 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17875720
14.
Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death.
Mol Cancer Ther
; 7(12): 3816-24, 2008 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19074856
15.
1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer.
J Nucl Med
; 49(2): 327-34, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18199615
16.
SPARC Inhibits Metabolic Plasticity in Ovarian Cancer.
Cancers (Basel)
; 10(10)2018 Oct 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30332737
17.
CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools.
Mol Cancer Res
; 16(11): 1687-1700, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30076241
18.
Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells.
Mol Cancer Ther
; 16(9): 1819-1830, 2017 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28615298
19.
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity.
Cancer Res
; 64(6): 2070-5, 2004 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-15026345
20.
Palmitoylation regulates the intracellular trafficking and stability of c-Met.
Oncotarget
; 7(22): 32664-77, 2016 May 31.
Artigo
Inglês
| MEDLINE | ID: mdl-27081699