Detalhe da pesquisa
1.
Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.
Cell
; 152(1-2): 340-51, 2013 Jan 17.
Artigo
Inglês
| MEDLINE | ID: mdl-23332765
2.
Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence.
Proc Natl Acad Sci U S A
; 116(7): 2603-2611, 2019 02 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30683717
3.
Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes.
Blood
; 117(12): 3257-67, 2011 Mar 24.
Artigo
Inglês
| MEDLINE | ID: mdl-21245485
4.
LKB1 modulates lung cancer differentiation and metastasis.
Nature
; 448(7155): 807-10, 2007 Aug 16.
Artigo
Inglês
| MEDLINE | ID: mdl-17676035
5.
Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice.
Arterioscler Thromb Vasc Biol
; 31(4): 827-33, 2011 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-21233453
6.
Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation.
Arterioscler Thromb Vasc Biol
; 31(11): 2483-92, 2011 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-21868699
7.
p16INK4a induces an age-dependent decline in islet regenerative potential.
Nature
; 443(7110): 453-7, 2006 Sep 28.
Artigo
Inglês
| MEDLINE | ID: mdl-16957737
8.
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.
Nature
; 443(7110): 448-52, 2006 Sep 28.
Artigo
Inglês
| MEDLINE | ID: mdl-16957738
9.
Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.
Cancer Res
; 67(10): 4732-41, 2007 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17510401
10.
Ink4a/Arf expression is a biomarker of aging.
J Clin Invest
; 114(9): 1299-307, 2004 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-15520862
11.
Chemotherapy and Stem Cell Transplantation Increase p16INK4a Expression, a Biomarker of T-cell Aging.
EBioMedicine
; 11: 227-238, 2016 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-27591832
12.
A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1.
Oncogene
; 21(10): 1469-76, 2002 Feb 28.
Artigo
Inglês
| MEDLINE | ID: mdl-11896574
13.
p16INK4a reporter mice reveal age-promoting effects of environmental toxicants.
J Clin Invest
; 124(1): 169-73, 2014 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-24334456
14.
Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer.
J Natl Cancer Inst
; 106(4): dju057, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24681605
15.
Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy.
Aging Cell
; 11(5): 916-8, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22738669
16.
p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age.
Dev Cell
; 17(1): 142-9, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19619499
17.
Stem cells and the rate of living.
Cell Stem Cell
; 1(1): 9-11, 2007 Jun 07.
Artigo
Inglês
| MEDLINE | ID: mdl-18371325
18.
RNA expression analysis of formalin-fixed paraffin-embedded tumors.
Lab Invest
; 87(4): 383-91, 2007 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-17297435
19.
Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses.
J Biol Chem
; 277(45): 43359-68, 2002 Nov 08.
Artigo
Inglês
| MEDLINE | ID: mdl-12213815