Detalhe da pesquisa
1.
Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells.
Proc Natl Acad Sci U S A
; 109(20): 7835-40, 2012 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22547816
2.
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Toxicol Appl Pharmacol
; 268(3): 318-30, 2013 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23403069
3.
Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells.
Mol Ther
; 20(4): 808-19, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22233583
4.
Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology.
Proc Natl Acad Sci U S A
; 107(32): 14443-8, 2010 Aug 10.
Artigo
Inglês
| MEDLINE | ID: mdl-20660723
5.
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.
Proc Natl Acad Sci U S A
; 107(46): 20021-6, 2010 Nov 16.
Artigo
Inglês
| MEDLINE | ID: mdl-21030678
6.
Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen.
Mol Ther
; 19(10): 1793-801, 2011 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-21505426
7.
A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics.
J Virol
; 84(12): 6007-17, 2010 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-20375153
8.
HMGB1 mediates endogenous TLR2 activation and brain tumor regression.
PLoS Med
; 6(1): e10, 2009 Jan 13.
Artigo
Inglês
| MEDLINE | ID: mdl-19143470
9.
High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity.
J Virol
; 82(9): 4680-4, 2008 May.
Artigo
Inglês
| MEDLINE | ID: mdl-18287240
10.
CD20, CD3, and CD40 ligand microclusters segregate three-dimensionally in vivo at B-cell-T-cell immunological synapses after viral immunity in primate brain.
J Virol
; 82(20): 9978-93, 2008 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-18684835
11.
Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain.
Mol Ther
; 16(2): 343-51, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18180781
12.
Flt3L in Combination With HSV1-TK-mediated Gene Therapy Reverses Brain Tumor-induced Behavioral Deficits.
Mol Ther
; 16(4): 682-690, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-28178463
13.
Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.
Mol Ther
; 16(4): 682-90, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-18283279
14.
Efficacy of nonviral gene transfer in the canine brain.
J Neurosurg
; 107(1): 136-44, 2007 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-17639883
15.
Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter.
J Neurosurg
; 107(3): 568-77, 2007 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-17886557
16.
Combining cytotoxic and immune-mediated gene therapy to treat brain tumors.
Curr Top Med Chem
; 5(12): 1151-70, 2005.
Artigo
Inglês
| MEDLINE | ID: mdl-16248789
17.
Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial.
Hum Gene Ther Methods
; 23(4): 271-84, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22950971
18.
Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics.
Neoplasia
; 14(8): 757-70, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22952428
19.
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.
Neurotherapeutics
; 9(4): 827-43, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22996231
20.
Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design.
Clin Cancer Res
; 17(14): 4705-18, 2011 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21632862