Detalhe da pesquisa
1.
Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.
Bioorg Med Chem Lett
; 89: 129303, 2023 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37146837
2.
Synthesis of biotinylated-LPG as a chemical biology tool enabling discovery of ALCAT1 modulators.
Bioorg Med Chem Lett
; 72: 128861, 2022 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35718103
3.
Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay.
Biochemistry
; 60(41): 3114-3124, 2021 10 19.
Artigo
Inglês
| MEDLINE | ID: mdl-34608799
4.
Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor.
Bioorg Med Chem Lett
; 30(23): 127602, 2020 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33038544
5.
Identification of potent inhibitors of the sortilin-progranulin interaction.
Bioorg Med Chem Lett
; 30(17): 127403, 2020 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32738972
6.
Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
Proc Natl Acad Sci U S A
; 114(3): E297-E306, 2017 01 17.
Artigo
Inglês
| MEDLINE | ID: mdl-28039433
7.
Discovery of Inactive Conformation-Selective Kinase Inhibitors by Utilizing Cascade Assays.
Biochemistry
; 56(34): 4449-4456, 2017 08 29.
Artigo
Inglês
| MEDLINE | ID: mdl-28574701
8.
Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett
; 23(12): 3584-8, 2013 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23664879
9.
Enzymatic capture of an extrahelical thymine in the search for uracil in DNA.
Nature
; 449(7161): 433-7, 2007 Sep 27.
Artigo
Inglês
| MEDLINE | ID: mdl-17704764
10.
Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1.
Sci Transl Med
; 15(684): eabn2038, 2023 02 22.
Artigo
Inglês
| MEDLINE | ID: mdl-36812345
11.
Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor.
Commun Biol
; 5(1): 787, 2022 08 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35931745
12.
Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.
ACS Med Chem Lett
; 12(4): 540-547, 2021 Apr 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33854701
13.
Development of a high-throughput cell-based assay for 11beta-hydroxysteroid dehydrogenase type 1 using BacMam technology.
Mol Biotechnol
; 39(2): 127-34, 2008 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-18327553
14.
Mimicking damaged DNA with a small molecule inhibitor of human UNG2.
Nucleic Acids Res
; 34(20): 5872-9, 2006.
Artigo
Inglês
| MEDLINE | ID: mdl-17062624
15.
Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity.
ACS Chem Biol
; 12(11): 2858-2865, 2017 11 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29024587
16.
Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) synthase is a zinc-metalloenzyme.
Biochim Biophys Acta
; 1594(2): 297-306, 2002 Feb 11.
Artigo
Inglês
| MEDLINE | ID: mdl-11904225
17.
Chronic inhibition of 11 ß -hydroxysteroid dehydrogenase type 1 activity decreases hypertension, insulin resistance, and hypertriglyceridemia in metabolic syndrome.
Biomed Res Int
; 2013: 427640, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23586038
18.
Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2.
Bioorg Med Chem
; 14(16): 5666-72, 2006 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16678429
19.
The catalytic power of uracil DNA glycosylase in the opening of thymine base pairs.
J Am Chem Soc
; 128(40): 13034-5, 2006 Oct 11.
Artigo
Inglês
| MEDLINE | ID: mdl-17017766
20.
The origins of high-affinity enzyme binding to an extrahelical DNA base.
Biochemistry
; 44(16): 5949-59, 2005 Apr 26.
Artigo
Inglês
| MEDLINE | ID: mdl-15835884