[BIOLOGICAL TREATMENT OF PSORIASIS IN TIME OF NEW CORONAVIRUS INFECTION COVID-19].

Currently, the ongoing pandemic of the novel coronavirus infection is still a major public health problem worldwide. The questions of immunosuppressive therapy of patients with psoriasis and psoriatic arthritis, the possibility of vaccination against the background of the use of genetically engineered drugs remain open. The article is of an overview nature and includes up-to-date information on the feasibility and safety of the use of genetically engineered biological drugs in patients with psoriasis in a pandemic (COVID-19). According to the international recommendations of the National Psoriasis Foundation COVID-19 Task Force expert group, treatment of psoriasis and/or PsA does not significantly alter the risk of SARS-CoV-2 infection and does not lead to worse prognosis of COVID-19. Therefore, patients not infected with SARS-CoV-2 should continue biological or other systemic therapy for psoriasis and/or PsA. According to a registry from 25 countries, hospitalization with SARS-CoV-2 infection was more common in patients receiving nonbiological systemic therapy than in patients receiving BAs. Thus, genetically engineered biological drugs do not appear to cause an increased risk of coronavirus infection and do not determine a more severe course. With regard to vaccination of patients with psoriasis, many issues require further study. According to international agreements, vaccination is not contraindicated in patients with psoriatic disease. However, there is still insufficient data on how the treatment of psoriatic disease affects vaccination. Avoiding COVID-19 or reducing the severity of infection following SARS-CoV-2 vaccination is thought to far outweigh any risk directly related to vaccination complications.

[Combined action of low-intensity laser radiation and autologous plasma with blood cells on the microcirculatory apparatus of the skin during involution changes.]

Involutional changes of the skin are associated with changes in its microcirculatory apparatus, among which spastic, atonic and mixed types are distinguished. The effect of low-intensity laser radiation in combination with autologous plasma with blood cells on the vascular component of the skin was studied. In the light of the restoration of the microcirculatory apparatus of the skin in different types, the clinical efficacy of the therapy was analyzed. The study of the effectiveness of low-intensity laser radiation in combination with autologous plasma with blood cells was conducted in 57 patients with clinical signs of involutive skin changes. Depending on the type of microcirculatory skin changes, all patients were divided into 3 comparable groups: the 1st - atonic type (n=24), the 2nd - spastic (n=12), the 3rd - mixed (n=21). The obtained data of a complex assessment of the dynamics of skin microcirculation, features of passive and active blood flow, indicate a significant pronounced positive effect of low-intensity laser radiation in combination with autologous plasma with blood cells in patients with spastic type of microcirculation.

Recovery treatment of lower limbs trophic ulcers in patients with chronic venous insufficiency (review of literature).

Trophic ulcers are complications of chronic venous insufficiency in 15-18% of cases and appear in 1-2% of able- bodied population. The frequency increases with age up to 4-5% among the patients aged over 65, and radical removalof the disease can be achieved only in one tenth of the patients. With that, even healed trophic ulcers recur frequently: after surgery in 4,8-31,6% of cases (according to various authors), after conservative treatment in 15-100% of cases. Main treatment modalities for trophic ulcers are medical and surgical. Recent researches necessitate including physical therapy methods into the treatment complex, as combined techniques that enable to improve results of various treatment variants.

Prophylaxis and rehabilitation of patients with chronic dermatosis (review of literature).

The article covers main aspects of sanatorium-and-spa treatment in chronic skin diseases.

Physical therapy methods for treatment and rehabilitation of oncologic patients (review of literature).

Oncologic morbidity has a tendency to steady rise. Treatment of oncologic patients, aimed to remove or cease malignant cells growth and prevent metastases, has considerable side effects and is conducted on psychologic stress background. Rehabilitation measures hence get crucial importance. Rehabilitation of oncologic patients in complex treatment is a multi-stage continuous recovery process that includes various influences. Correct implementation of physical therapy factors in rehabilitation program causes no tumor growth and metastases, and sometimes inhibits tumor cells growth. On recommendations of sanatorium-and-spa treatment for oncologic patients, the complex promotes rapid recovery of disordered functions, activation of adaptive responses, psychologic and social adjustment.

[Combined treatment of palmoplantar syndrome in patients under antitumor therapy].

Observation covered 12 patients under various antitumor medications. Group 1 was formed of patients with developed palmoplantar syndrome varying in severity, who received complex treatment including IR-therapy and local antioxidant medication. Group 2 included patients without palmoplantar syndrome, who received preventive treatment with IR-therapy. All patients of group 1 demonstrated lower severity of palmoplantar syndrome manifestations. In group 2, 80% of the patients avoided palmoplantar syndrome development, and 20% of the patients had light course of the syndrome manifestations. Patients at high risk of palmoplantar syndrome under antitumor therapy are recommended to undergo IR-therapy and local antioxidant medication.

[Approaches to phototherapy in children with chronic dermatosis (review of literature)].

The article covers main aspects of phototherapy and photochemotherapy in treatment of skin diseases in children, risks of such methods usage, prophylactic and therapeutic measures, and precaution means for such treatment in pediatrics.

[Variations of HBD-2 and TLR-2 gene expression in patients presenting with lichen ruber planus under effect of ultraviolet irradiation].

The combination of narrow-band range UV-A (311 nm) and middle/broad-band UV-B (320-400 nm) irradiation was shown to significantly reduce manifestations of objective and subjective symptoms in the patients presenting with lichen ruber planus. Moreover, it promoted elimination ofdisbalance between characteristics of congenital immunity and normalization of HBD-2 and TLR-2 gene expression.

[Mental disorders, social maladaptation and quality of life of patients with acne and post-acne symptoms]. / Psikhicheskie rasstroistva, sotsial'naia dezadaptatsiia i kachestvo zhizni patsientov s akne i simptomami postakne.

AIM: A comparative analysis of the psycho-emotional status and quality of life of patients with acne and post-acne. MATERIAL AND METHODS: There were 147 patients included in the study, 84 (57%) women and 63 (43%) men, aged from 14 to 48 years. The following parameters were studied: CADI score, APSEA score, DLQI score. Anxiety and depression were assessed with HAM-D and HAM-A. RESULTS: Higher scores on CADI, APSEA and DLQI and dissatisfaction with the results of therapy were noted in older patients. Significant changes in CADI, APSEA and DLQI scores in patients with post-acne symptoms were recorded later compared to patients with acne. Anxiety and depression symptoms measured with HAM-D and HAM-A reached the level of depressive disorder of moderate severity and moderate anxiety in patients over 20 years old. Mental disorders were qualified within the nosogenic anxiety-phobic reactions developing in connection with dermatosis manifestation. CONCLUSION: Acnes substantially better give in to correction than post-acne symptom complex. Regardless of age, post-acne symptoms considerably reduce quality of life of patients, sometimes causing more expressed changes (anxiety and depression) than dermatosis.