RESUMO
Currently, the only effective method of treatment and rehabilitation of patients with inactive thyroid eye disease (TED) is orbital decompression. This review analyzes the prospects of using prostaglandin analogues (PGF2ß) to decrease the volume of orbital fat in order to reduce proptosis and periorbital changes in TED. Despite the fact that the available data on the results of using PGF2ß analogues in patients with TED are contradictory, were based on short follow-up periods and involved only a small number of patients, we believe that this topic is a very promising avenue for further research.
Assuntos
Exoftalmia , Oftalmopatia de Graves , Humanos , Oftalmopatia de Graves/diagnóstico , Oftalmopatia de Graves/tratamento farmacológico , Oftalmopatia de Graves/cirurgia , Prostaglandinas Sintéticas , Exoftalmia/cirurgia , Órbita/cirurgia , Descompressão Cirúrgica/métodos , Estudos RetrospectivosRESUMO
A comparative study was performed of the processes of autolytic degradation of the cells of Saccharomyces cerevisiae and Schizosaccharomyces pombe under conditions simulating the phase of cell death in microbial cultures: (1) during autolysis induced by oleic acid, which is the chemical analogue of factors d2 (autolysis autoinducer), (2) under the effect of extracellular microbial proteinases (enzymatic lysis), and (3) under concomitant effect of the enzymes of the endogenous autolytic complex and exogenous proteinases (heterolysis). Regulatory mechanisms controlling the rate and profundity of autolysis were elucidated, relying on the stabilization of hydrolytic enzymes and enhancement of their activity in their complexes with a chemical analogue of microbial autoregulatory factors d1, which belong to alkylhydroxybenzenes and fulfil functions of chemical chaperons. The changes in the activity of proteinases and enzymes of the autolytic complex were shown to be dependent on the concentration of the analogue at the moment of complex formation.