Detalhe da pesquisa
1.
Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes.
Diabetologia
; 61(2): 399-412, 2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-28988346
2.
[Interaction between environment and genetic background in type 2 diabetes: lessons from animal models]. / Interaction entre facteurs d'environnement et fonds génétique dans le diabète de type 2 - L'apport des modèles animaux.
Med Sci (Paris)
; 29(8-9): 791-9, 2013.
Artigo
Francês
| MEDLINE | ID: mdl-24005636
3.
Synthesis and evaluation of new polyenic compounds as potential PPARs modulators.
Org Biomol Chem
; 10(30): 6169-85, 2012 Aug 14.
Artigo
Inglês
| MEDLINE | ID: mdl-22641289
4.
Chromosomal mapping of pancreatic islet morphological features and regulatory hormones in the spontaneously diabetic (Type 2) Goto-Kakizaki rat.
Mamm Genome
; 21(9-10): 499-508, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-20878524
5.
Synthesis of new 8(S)-HETE analogs and their biological evaluation as activators of the PPAR nuclear receptors.
J Enzyme Inhib Med Chem
; 25(5): 653-72, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-20518620
6.
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.
Bioorg Med Chem Lett
; 19(10): 2683-7, 2009 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19376700
7.
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation.
Bioorg Med Chem Lett
; 18(5): 1617-22, 2008 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18255290
8.
Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing.
Diabetes
; 55(7): 2084-90, 2006 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-16804079
9.
Transgenic expression of human INS gene in Ins1/Ins2 double knockout mice leads to insulin underproduction and diabetes in some male mice.
Front Biosci
; 12: 1586-93, 2007 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17127405
10.
[Anatomical and functional plasticity of pancreatic beta-cells and type 2 diabetes]. / Plasticité anatomique et fonctionnelle des cellules bêta du pancréas endocrine et diabète de type 2.
Med Sci (Paris)
; 23(10): 885-94, 2007 Oct.
Artigo
Francês
| MEDLINE | ID: mdl-17937902
11.
Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.
Eur J Med Chem
; 137: 310-326, 2017 Sep 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28609708
12.
Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans.
Cell Rep
; 18(9): 2269-2279, 2017 02 28.
Artigo
Inglês
| MEDLINE | ID: mdl-28249170
13.
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.
Mol Metab
; 6(4): 340-351, 2017 04.
Artigo
Inglês
| MEDLINE | ID: mdl-28377873
14.
Psammomys obesus, a model for environment-gene interactions in type 2 diabetes.
Diabetes
; 54 Suppl 2: S137-44, 2005 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-16306331
15.
Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control.
Diabetes
; 54(1): 138-45, 2005 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-15616021
16.
Structure-Activity Relationship of Azaindole-Based Glucokinase Activators.
J Med Chem
; 59(2): 687-706, 2016 Jan 28.
Artigo
Inglês
| MEDLINE | ID: mdl-26685731
17.
Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.
Physiol Genomics
; 19(1): 1-10, 2004 Sep 16.
Artigo
Inglês
| MEDLINE | ID: mdl-15266047
18.
Specific and combined effects of insulin and glucose on functional pancreatic beta-cell mass in vivo in adult rats.
Endocrinology
; 144(6): 2717-27, 2003 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-12746336
19.
Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production.
Eur J Med Chem
; 39(6): 473-80, 2004 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15183905
20.
Analysis of sterol-regulatory element-binding protein 1c target genes in mouse liver during aging and high-fat diet.
J Nutrigenet Nutrigenomics
; 6(2): 107-22, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23774190