1.
Antimicrob Agents Chemother
; 49(10): 4354-7, 2005 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16189120
RESUMO
We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.