Detalhe da pesquisa
1.
Di-fluoro azepane HBV capsid assembly modulators.
Bioorg Med Chem Lett
; 92: 129350, 2023 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37247697
2.
Diazepinone HBV capsid assembly modulators.
Bioorg Med Chem Lett
; 72: 128823, 2022 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35644301
3.
Tandem Amination/Oxetane Ring Opening toward Benzomorpholines.
J Org Chem
; 86(23): 17482-17486, 2021 12 03.
Artigo
Inglês
| MEDLINE | ID: mdl-34807596
4.
Oxadiazepinone HBV capsid assembly modulators.
Bioorg Med Chem Lett
; 52: 128353, 2021 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34492302
5.
Identification of a new class of HBV capsid assembly modulator.
Bioorg Med Chem Lett
; 39: 127848, 2021 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33610748
6.
A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.
Bioorg Med Chem Lett
; 30(22): 127589, 2020 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33007394
7.
Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus.
Antimicrob Agents Chemother
; 63(1)2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30373799
8.
SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.
Bioorg Med Chem Lett
; 29(16): 2405-2409, 2019 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31227344
9.
Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622.
J Pharmacol Exp Ther
; 365(3): 556-566, 2018 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29563325
10.
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists.
Bioorg Med Chem Lett
; 27(6): 1364-1370, 2017 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28216403
11.
Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain.
J Neurogenet
; 30(1): 32-41, 2016 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27276194
12.
Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology.
Bioorg Med Chem Lett
; 26(23): 5809-5814, 2016 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27818110
13.
The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys.
J Pharmacol Exp Ther
; 355(3): 442-50, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26446308
14.
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Bioorg Med Chem Lett
; 25(3): 444-50, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25577040
15.
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
Bioorg Med Chem Lett
; 25(12): 2488-92, 2015 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25981685
16.
Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
Bioorg Med Chem Lett
; 25(21): 4992-4999, 2015 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25613676
17.
Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators.
BMC Neurosci
; 15: 109, 2014 Sep 22.
Artigo
Inglês
| MEDLINE | ID: mdl-25242351
18.
Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.
Bioorg Med Chem Lett
; 24(5): 1417-20, 2014 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24485781
19.
Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant.
Bioorg Med Chem Lett
; 24(7): 1784-9, 2014 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24630562
20.
Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.
ACS Med Chem Lett
; 15(3): 381-387, 2024 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38505861