Detalhe da pesquisa
1.
Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
Bioorg Med Chem Lett
; 27(6): 1478-1483, 2017 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28190634
2.
Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonists.
Bioorg Med Chem Lett
; 26(9): 2303-7, 2016 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27020304
3.
Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.
Bioorg Med Chem Lett
; 26(19): 4824-4828, 2016 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27554445
4.
Discovery and characterization of a potent and selective EP4 receptor antagonist.
Bioorg Med Chem Lett
; 25(16): 3176-8, 2015 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26091726
5.
Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain.
Eur J Nucl Med Mol Imaging
; 40(2): 245-53, 2013 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23135321
6.
3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity.
Bioorg Med Chem Lett
; 22(7): 2514-7, 2012 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22386665
7.
Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury.
J Med Chem
; 61(5): 2041-2051, 2018 03 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29425457
8.
Analgesic and anti-inflammatory properties of novel, selective, and potent EP4 receptor antagonists.
Pharmacol Res Perspect
; 5(3): e00316, 2017 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28603634
9.
Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.
J Med Chem
; 59(1): 194-205, 2016 Jan 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26653180
10.
Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J Med Chem
; 58(11): 4727-37, 2015 Jun 11.
Artigo
Inglês
| MEDLINE | ID: mdl-25961169
11.
Privileged structure based ligands for melanocortin-4 receptors--aliphatic piperazine derivatives.
Bioorg Med Chem Lett
; 16(13): 3449-53, 2006 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16650763
12.
Privileged structure based ligands for melanocortin receptors--4,4-disubstituted piperidine derivatives.
Bioorg Med Chem Lett
; 16(14): 3843-6, 2006 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16697186