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1.
Mycoses ; 62(4): 310-319, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30426598

RESUMO

BACKGROUND: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU). OBJECTIVES: To develop a standard set of definitions for IFD in critically ill adult patients in ICU. METHODS: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. The proposed definitions will be evaluated by a panel of 30 experts using the RAND/UCLA appropriateness methods. The panel will rank each of the proposed definitions on a 1-9 scale trough a dedicated questionnaire, in two rounds: one remote and one face-to-face. Based on their median rank and the level of agreement across panel members, selected definitions will be organised in a main consensus document and in an executive summary. The executive summary will be made available online for public comments. CONCLUSIONS: The present consensus project will seek to provide standard definitions for IFD in critically ill adult patients in ICU, with the ultimate aims of improving their clinical outcome and facilitating the comparison and generalizability of research findings.


Assuntos
Estado Terminal , Unidades de Terapia Intensiva , Infecções Fúngicas Invasivas/diagnóstico , Infecções Fúngicas Invasivas/patologia , Terminologia como Assunto , Consenso , Humanos
3.
Intensive Care Med ; 50(4): 502-515, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38512399

RESUMO

PURPOSE: The aim of this document was to develop standardized research definitions of invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted to intensive care units (ICUs). METHODS: After a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method. RESULTS: Standardized research definitions were developed for proven invasive candidiasis, probable deep-seated candidiasis, proven invasive aspergillosis, probable invasive pulmonary aspergillosis, and probable tracheobronchial aspergillosis. The limited evidence on the performance of existing definitions and laboratory tests for the diagnosis of IFD other than candidiasis and aspergillosis precluded the development of dedicated definitions, at least pending further data. The standardized definitions provided in the present document are aimed to speed-up the design, and increase the feasibility, of future comparative research studies.


Assuntos
Aspergilose , Candidíase Invasiva , Infecções Fúngicas Invasivas , Adulto , Humanos , Consenso , Infecções Fúngicas Invasivas/diagnóstico , Aspergilose/diagnóstico , Candidíase Invasiva/diagnóstico , Unidades de Terapia Intensiva
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