Detalhe da pesquisa
1.
Unexpected Single-Ligand Occupancy and Negative Cooperativity in the SARS-CoV-2 Main Protease.
J Chem Inf Model
; 64(3): 892-904, 2024 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-38051605
2.
Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation.
Biol Chem
; 404(4): 355-375, 2023 03 28.
Artigo
Inglês
| MEDLINE | ID: mdl-36774650
3.
Design, synthesis and biological evaluation of antiparasitic dinitroaniline-ether phospholipid hybrids.
Bioorg Chem
; 138: 106615, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37244229
4.
Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L.
Int J Mol Sci
; 22(21)2021 Oct 29.
Artigo
Inglês
| MEDLINE | ID: mdl-34769210
5.
Design, Synthesis and Antiparasitic Evaluation of Click Phospholipids.
Molecules
; 26(14)2021 Jul 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34299479
6.
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.
Proc Natl Acad Sci U S A
; 113(44): 12544-12549, 2016 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27791151
7.
Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.
Arch Toxicol
; 92(4): 1435-1451, 2018 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-29356861
8.
Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.
Molecules
; 22(3)2017 Mar 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28282886
9.
Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex.
Virus Res
; 343: 199356, 2024 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38490582
10.
DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action.
Viruses
; 15(5)2023 05 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37243214
11.
Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy.
J Med Chem
; 66(15): 10252-10264, 2023 08 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37471520
12.
High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents.
J Med Chem
; 66(22): 15230-15255, 2023 11 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37921561
13.
High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1.
Biomed Pharmacother
; 151: 113104, 2022 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-35643072
14.
Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route.
Eur J Med Chem
; 244: 114853, 2022 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36332546
15.
Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.
J Med Chem
; 65(13): 9011-9033, 2022 07 14.
Artigo
Inglês
| MEDLINE | ID: mdl-35675511
16.
Corrigendum to "Machine Learning Based Prediction of COVID-19 Mortality Suggests Repositioning of Anticancer Drug for Treating Severe Cases"[Artificial Intelligence in Life Sciences] 1(2021), 100020.
Artif Intell Life Sci
; 2: 100032, 2022 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-35156080
17.
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort.
Sci Data
; 9(1): 405, 2022 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-35831315
18.
A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection.
Sci Data
; 8(1): 70, 2021 02 26.
Artigo
Inglês
| MEDLINE | ID: mdl-33637768
19.
A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics.
ACS Pharmacol Transl Sci
; 4(3): 1079-1095, 2021 Jun 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34136757
20.
The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines.
Eur J Med Chem
; 209: 112871, 2021 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33070078