Detalhe da pesquisa
1.
Pancreatic ß-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).
J Biol Chem
; 292(36): 14977-14988, 2017 09 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28698383
2.
Central role and mechanisms of ß-cell dysfunction and death in friedreich ataxia-associated diabetes.
Ann Neurol
; 72(6): 971-82, 2012 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-23280845
3.
In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo.
Front Cell Dev Biol
; 10: 967765, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36060810
4.
DNAJC3 deficiency induces ß-cell mitochondrial apoptosis and causes syndromic young-onset diabetes.
Eur J Endocrinol
; 184(3): 455-468, 2021 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-33486469
5.
Cell-permeable peptides induce dose- and length-dependent cytotoxic effects.
Biochim Biophys Acta
; 1768(9): 2222-34, 2007 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-17626783
6.
Guanabenz Sensitizes Pancreatic ß Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis.
Endocrinology
; 158(6): 1659-1670, 2017 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28323924
7.
High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced ß-cell apoptosis.
Biochem Pharmacol
; 138: 140-149, 2017 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28522407
8.
MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic ß-Cells.
Diabetes
; 66(1): 100-112, 2017 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-27737950
9.
Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.
Diabetes
; 54(8): 2396-403, 2005 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-16046307
10.
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.
Endocrinology
; 145(11): 5087-96, 2004 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-15297438
11.
Metabolism of 13C-enriched D-fructose in hepatocytes from Goto-Kakizaki rats.
Int J Mol Med
; 13(5): 697-703, 2004 May.
Artigo
Inglês
| MEDLINE | ID: mdl-15067373
12.
Pharmacodynamics, insulinotropic action and hypoglycemic effect of nateglinide and glibenclamide in normal and diabetic rats.
Int J Mol Med
; 11(1): 105-9, 2003 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-12469228
13.
Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis.
Mol Nutr Food Res
; 58(10): 1980-90, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25044754
14.
RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.
Diabetes
; 63(6): 1978-93, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24379348
15.
Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction.
Mol Cell Endocrinol
; 367(1-2): 1-10, 2013 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-23246353
16.
Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1ß in pancreatic rat ß-cells via the IRE1α/XBP1s pathway.
Endocrinology
; 153(7): 3017-28, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22529213
17.
Perturbation of glycerol metabolism in hepatocytes from n3-PUFA-depleted rats.
Int J Mol Med
; 29(6): 1121-6, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22426780
18.
In vitro use of free fatty acids bound to albumin: A comparison of protocols.
Biotechniques
; 58(5): 228-33, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-25967901
19.
Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.
J Clin Endocrinol Metab
; 95(3): 1442-9, 2010 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-20080856
20.
Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells.
Diabetes
; 59(2): 358-74, 2010 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19934004