The role of various physiological and bioelectrical parameters for estimating the weight status in infants and juveniles cohort from the Southern Cuba region: a machine learning study.

OBJECTIVE: The search for other indicators to assess the weight status of individuals is important as it may provide more accurate information and assist in personalized medicine.This work is aimed to develop a machine learning predictions of weigh status derived from bioimpedance measurements and other physical parameters of healthy infant juvenile cohort from the Southern Cuba Region, Santiago de Cuba. METHODS: The volunteers were selected between 2002 and 2008, ranging in age between 2 and 18 years old. In total, 393 female and male infant and juvenile individuals are studied. The bioimpedance parameters are obtained by measuring standard tetrapolar whole-body configuration. A classification model are performed, followed by a prediction of other bioparameters influencing the weight status. RESULTS: The results obtained from the classification model indicate that fat-free mass, reactance, and corrected resistance primarily influence the weight status of the studied population. Specifically, the regression model demonstrates that other bioparameters derived from impedance measurements can be highly accurate in estimating weight status. CONCLUSION: The classification and regression predictive models developed in this work are of the great importance for accessing to the weigh status with high accuracy of younger individuals at the Oncological Hospital in Santiago de Cuba, Cuba.

Integrating classification and regression learners with bioimpedance methods for estimating weight status in infants and juveniles from the southern Cuba region.

OBJECTIVE: The search for other indicators to assess the weight and nutritional status of individuals is important as it may provide more accurate information and assist in personalized medicine. This work is aimed to develop a machine learning predictions of weigh status derived from bioimpedance measurements and other physical parameters of healthy younger volunteers from Southern Cuba Region. METHODS: A pilot random study at the Pediatrics Hospital was conducted. The volunteers were selected between 2002 and 2008, ranging in age between 2 and 18 years old. In total, 776 female and male volunteers are studied. Along the age and sex in the cohort, volunteers with class I obesity, overweight, underweight and with normal weight are considered. The bioimpedance parameters are obtained by measuring standard tetrapolar whole-body configuration. The bioimpedance analyser is used, collecting fundamental bioelectrical and other parameters of interest. A classification model are performed, followed by a prediction of the body mass index. RESULTS: The results derived from the classification leaner reveal that the size, body density, phase angle, body mass index, fat-free mass, total body water volume according to Kotler, body surface area, extracellular water according to Kotler and sex largely govern the weight status of this population. In particular, the regression model shows that other bioparameters derived from impedance measurements can be associated with weight status estimation with high accuracy. CONCLUSION: The classification and regression predictive models developed in this work are of the great importance to assist the diagnosis of weigh status with high accuracy. These models can be used for prompt weight status evaluation of younger individuals at the Pediatrics Hospital in Santiago de Cuba, Cuba.

Bioelectrical parameters of the whole human body obtained through bioelectrical impedance analysis.

Knowledge of electrical properties of body tissues across the frequency spectrum is useful for tissue characterization. The bioelectric impedance analysis method, operating from 1 to 250 kHz (multi-frequency), was used in 23 normal male human subjects between the ages of 21 and 52 years, for estimation of their bioelectrical parameters. Amplitude of the output current was set to 800 microA(RMS). The experimental data showed that bioelectric parameters were highly dependent on frequency and the presence of a threshold frequency around 4 kHz. In order to explain the unusual features observed in our experimental data, the human body was simulated through the Cole-Fricke-Cole model (RC circuit) and the Extended Cole-Fricke-Cole model (RLC circuit). The simulated data showed that the Extended Cole-Fricke-Cole model had a higher accuracy than the traditional Cole-Fricke-Cole model. These results suggest that the unusual features could be due to the possible existence of inductive effects in biological cells and body tissues and that the inductive parameter and the threshold frequency could be used for characterizing the healthy tissues as well as the traditional bioelectric parameters.

Efectos de la corriente eléctrica directa en el tumor murino subcutáneo de Ehrlich. I: Estudios de necrosis y volumen del tumor en estadíos avanzados / Direct eletric current effects on the Ehrlich subcutaneous murine tumor. I: Necrosis and volume of tumor studies in advanced stages

La electroterapia con corriente eléctrica direta se aplicó a un modelo de tumor murino subcutáneo (tumor de Ehrlich). La corriente fue suministrada a través de electrodos de Pt, donde el cátodo fue introducido directamente en los tumores y el ánodo subcutáneamente en la vencidad de éstos. Después de la electroterapia de un solo estímulo se observó que la disminución del volumen y el porcentaje de necrosis de los tumores fueron significativos y dependientes de la intensidad de corriente directa (1,8 y 4 mA). En la electroterapia repetitiva con 1,8 y 4 mA en diferentes días y zonas del tumor, también se observó disminución del volumen del tumor. Los grupos controles en ambos casos fueron sometidos a las mismas condiciones, pero no se les suministró corriente eléctrica. Estos resultados indican que la electroterapia en estadíos avanzados también puede ser una terapia antitumoral efectiva y que sus efectos son mejores a mayores intensidades de corriente. Se concluyó que la electroterapia para estos estadíos debe aplicarse mediante el empleo de un arreglo de electrodos dispuesto simétricamente en todo el tumor o en secciones de éste por separado, con el objetivo de disminuir los altos voltajes que se aplican entre los electrodos.