Pesquisa | Secretaria de Estado da Saúde

1.

Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats.

Fishman, Cindy; Caverly Rae, Jessica M; Posobiec, Lorraine M; Laffan, Susan B; Lerman, Steven A; Pearson, Neil; Janmohamed, Salim; Dumont, Etienne; Nunn-Floyd, Deatra; Stanislaus, Dinesh J.

Antimicrob Agents Chemother ; 66(11): e0048322, 2022 11 15.

Artigo Inglês | MEDLINE | ID: mdl-36255258

2.

The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.

Cadilla, Rodolfo; Deaton, David N; Do, Young; Elkins, Patricia A; Ennulat, Daniela; Guss, Jeffrey H; Holt, Jason; Jeune, Michael R; King, Andrew G; Klapwijk, Jan C; Kramer, H Fritz; Kramer, Nicholas J; Laffan, Susan B; Masuria, Paresh I; McDougal, Alan V; Mortenson, Paul N; Musetti, Caterina; Peckham, Gregory E; Pietrak, Beth L; Poole, Chuck; Price, Daniel J; Rendina, Alan R; Sati, Girish; Saxty, Gordon; Shearer, Barry G; Shewchuk, Lisa M; Sneddon, Helen F; Stewart, Eugene L; Stuart, J Darren; Thomas, Dean N; Thomson, Stephen A; Ward, Paris; Wilson, Joseph W; Xu, Tiahshun; Youngman, Mark A.

Bioorg Med Chem ; 28(23): 115791, 2020 12 01.

Artigo Inglês | MEDLINE | ID: mdl-33059303

3.

Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects.

Theunissen, Peter T; Beken, Sonia; Beyer, Bruce; Breslin, William J; Cappon, Gregg D; Chen, Connie L; Chmielewski, Gary; de Schaepdrijver, Luc; Enright, Brian; Foreman, Jennifer E; Harrouk, Wafa; Hew, Kok-Wah; Hoberman, Alan M; Y Hui, Julia; Knudsen, Thomas B; Laffan, Susan B; Makris, Susan L; Martin, Matthew; McNerney, Mary Ellen; Siezen, Christine L; Stanislaus, Dinesh J; Stewart, Jane; Thompson, Kary E; Tornesi, Belen; Van der Laan, Jan Willem; Weinbauer, Gerhard F; Wood, Sandra; Piersma, Aldert H.

Crit Rev Toxicol ; 47(5): 402-414, 2017 May.

Artigo Inglês | MEDLINE | ID: mdl-27766926

4.

Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects.

Theunissen, Peter T; Beken, Sonja; Beyer, Bruce K; Breslin, William J; Cappon, Gregg D; Chen, Connie L; Chmielewski, Gary; De Schaepdrijver, Luc; Enright, Brian; Foreman, Jennifer E; Harrouk, Wafa; Hew, Kok-Wah; Hoberman, Alan M; Hui, Julia Y; Knudsen, Thomas B; Laffan, Susan B; Makris, Susan L; Martin, Matt; McNerney, Mary Ellen; Siezen, Christine L; Stanislaus, Dinesh J; Stewart, Jane; Thompson, Kary E; Tornesi, Belen; Van der Laan, Jan Willem; Weinbauer, Gerhard F; Wood, Sandra; Piersma, Aldert H.

Crit Rev Toxicol ; 46(10): 900-910, 2016 11.

Artigo Inglês | MEDLINE | ID: mdl-27848393

5.

Early Vaginal Opening in Juvenile Female Rats Given BRAF-Inhibitor Dabrafenib Is Not Associated with Early Physiologic Sexual Maturation.

Posobiec, Lorraine M; Vidal, Justin D; Hughes-Earle, Angela; Laffan, Susan B; Hart, Timothy.

Birth Defects Res B Dev Reprod Toxicol ; 104(6): 244-52, 2015 Dec.

Artigo Inglês | MEDLINE | ID: mdl-26626128

6.

The inhibin B response to a motilin receptor agonist in male rats.

Ziejewski, Mary K; Vidal, Justin D; Stanislaus, Dinesh; Apostoli, April; Chowdhury, Probash; Laffan, Susan.

Birth Defects Res B Dev Reprod Toxicol ; 98(1): 63-71, 2013 Feb.

Artigo Inglês | MEDLINE | ID: mdl-23348917

7.

Dihydroartemisinin (DHA) treatment causes an arrest of cell division and apoptosis in rat embryonic erythroblasts in whole embryo culture.

Posobiec, Lorraine M; Clark, Robert L; Bushdid, Paul B; Laffan, Susan B; Wang, Kai-Fen; White, Tacey E K.

Birth Defects Res B Dev Reprod Toxicol ; 98(6): 445-58, 2013 Dec.

Artigo Inglês | MEDLINE | ID: mdl-24391093

8.

Summary of the HESI consortium studies exploring circulating inhibin B as a potential biomarker of testis damage in the rat.

Chapin, Robert; Weinbauer, Gerhard; Thibodeau, Michael S; Sonee, Manisha; Saldutti, Louise Parks; Reagan, William J; Potter, David; Moffit, Jeffrey S; Laffan, Susan; Kim, James H; Goldstein, Richard A; Erdos, Zoltan; Enright, Brian P; Coulson, Michelle; Breslin, William J.

Birth Defects Res B Dev Reprod Toxicol ; 98(1): 110-8, 2013 Feb.

Artigo Inglês | MEDLINE | ID: mdl-23364877

9.

The benefits, limitations and opportunities of preclinical models for neonatal drug development.

Campion, Sarah; Inselman, Amy; Hayes, Belinda; Casiraghi, Costanza; Joseph, David; Facchinetti, Fabrizio; Salomone, Fabrizio; Schmitt, Georg; Hui, Julia; Davis-Bruno, Karen; Van Malderen, Karen; Morford, LaRonda; De Schaepdrijver, Luc; Wiesner, Lutz; Kourula, Stephanie; Seo, Suna; Laffan, Susan; Urmaliya, Vijay; Chen, Connie.

Dis Model Mech ; 15(4)2022 04 01.

Artigo Inglês | MEDLINE | ID: mdl-35466995

10.

Dose range finding approach for rodent preweaning juvenile animal studies.

Posobiec, Lorraine M; Laffan, Susan B.

Birth Defects Res ; 113(5): 409-426, 2021 03 15.

Artigo Inglês | MEDLINE | ID: mdl-33314670

11.

The spirit of nursing.

Laffan, Susan.

Nursing ; 45(4): 8, 2015 Apr.

Artigo Inglês | MEDLINE | ID: mdl-25954781

12.

Absence of developmental and reproductive toxicity in animals exposed to dolutegravir.

Stanislaus, Dinesh J; Posobiec, Lorraine M; Laffan, Susan B; Solomon, Howard M; Ziejewski, Mary K; Romach, Elizabeth H.

Birth Defects Res ; 112(3): 245-261, 2020 02 01.

Artigo Inglês | MEDLINE | ID: mdl-31859466

13.

Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates.

Laffan, Susan B; Thomson, Andrew S; Mai, Shing; Fishman, Cindy; Kambara, Takahito; Nistala, Kiran; Raymond, James T; Chen, Shugui; Ramani, Thulasi; Pageon, Laura; Polsky, Rodd; Watkins, Mark; Ottolangui, Gemma; White, John R; Maier, Curtis; Herdman, Michael; Bouma, Gerben.

PLoS One ; 15(4): e0231655, 2020.

Artigo Inglês | MEDLINE | ID: mdl-32325480

14.

Memorable moments.

Laffan, Susan.

Nursing ; 44(12): 9, 2014 Dec.

Artigo Inglês | MEDLINE | ID: mdl-25406774

15.

Species Comparison of Postnatal Development of the Female Reproductive System.

Laffan, Susan B; Posobiec, Lorraine M; Uhl, Jenny E; Vidal, Justin D.

Birth Defects Res ; 110(3): 163-189, 2018 02 15.

Artigo Inglês | MEDLINE | ID: mdl-29243395

16.

Imaging MS in Toxicology: An Investigation of Juvenile Rat Nephrotoxicity Associated with Dabrafenib Administration.

Groseclose, M Reid; Laffan, Susan B; Frazier, Kendall S; Hughes-Earle, Angela; Castellino, Stephen.

J Am Soc Mass Spectrom ; 26(6): 887-98, 2015 Jun.

Artigo Inglês | MEDLINE | ID: mdl-25804893

17.

Assessing a theoretical risk of dolutegravir-induced developmental immunotoxicity in juvenile rats.

Rhodes, Melissa; Laffan, Susan; Genell, Caroline; Gower, Jill; Maier, Curtis; Fukushima, Tamio; Nichols, Garrett; Bassiri, Ashlyn Eaton.

Toxicol Sci ; 130(1): 70-81, 2012 Nov.

Artigo Inglês | MEDLINE | ID: mdl-22790968

18.

The 'inside look' on correctional nursing: a unique nursing speciality.

Laffan, Susan.

N J Nurse ; 35(1): 6, 2005.

Artigo Inglês | MEDLINE | ID: mdl-15790009

19.

Job satisfaction and the effects of the current nationwide nursing shortage.

Laffan, Susan.

N J Nurse ; 32(7): 5-6, 2002.

Artigo Inglês | MEDLINE | ID: mdl-12400197

20.

Artesunate-induced depletion of embryonic erythroblasts precedes embryolethality and teratogenicity in vivo.

White, Tacey E K; Bushdid, Paul B; Ritter, Sandra; Laffan, Susan B; Clark, Robert L.

Birth Defects Res B Dev Reprod Toxicol ; 77(5): 413-29, 2006 Oct.

Artigo Inglês | MEDLINE | ID: mdl-17066416

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Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats.

The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.

Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects.

Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects.

Early Vaginal Opening in Juvenile Female Rats Given BRAF-Inhibitor Dabrafenib Is Not Associated with Early Physiologic Sexual Maturation.

The inhibin B response to a motilin receptor agonist in male rats.

Dihydroartemisinin (DHA) treatment causes an arrest of cell division and apoptosis in rat embryonic erythroblasts in whole embryo culture.

Summary of the HESI consortium studies exploring circulating inhibin B as a potential biomarker of testis damage in the rat.

The benefits, limitations and opportunities of preclinical models for neonatal drug development.

Dose range finding approach for rodent preweaning juvenile animal studies.

The spirit of nursing.

Absence of developmental and reproductive toxicity in animals exposed to dolutegravir.

Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates.

Memorable moments.

Species Comparison of Postnatal Development of the Female Reproductive System.

Imaging MS in Toxicology: An Investigation of Juvenile Rat Nephrotoxicity Associated with Dabrafenib Administration.

Assessing a theoretical risk of dolutegravir-induced developmental immunotoxicity in juvenile rats.

The 'inside look' on correctional nursing: a unique nursing speciality.

Job satisfaction and the effects of the current nationwide nursing shortage.

Artesunate-induced depletion of embryonic erythroblasts precedes embryolethality and teratogenicity in vivo.