Detalhe da pesquisa
1.
Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
PLoS Biol
; 20(5): e3001621, 2022 May.
Artigo
Inglês
| MEDLINE | ID: mdl-35507910
2.
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
PLoS Biol
; 19(12): e3001480, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34914695
3.
Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes.
Glia
; 69(3): 681-696, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33045109
4.
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
Neurobiol Dis
; 141: 104948, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32434048
5.
Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils.
Neurobiol Dis
; 129: 67-78, 2019 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31102768
6.
In vivo quantification of glial activation in minipigs overexpressing human α-synuclein.
Synapse
; 72(12): e22060, 2018 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30009467
7.
Toxic effects of human and rodent variants of alpha-synuclein in vivo.
Eur J Neurosci
; 45(4): 536-547, 2017 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27893183
8.
Assessment of brain metabolite correlates of adeno-associated virus-mediated over-expression of human alpha-synuclein in cortical neurons by in vivo (1) H-MR spectroscopy at 9.4 T.
J Neurochem
; 137(5): 806-19, 2016 06.
Artigo
Inglês
| MEDLINE | ID: mdl-26811128
9.
Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.
Neurobiol Dis
; 78: 100-14, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25818009
10.
Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.
Brain
; 137(Pt 9): 2493-508, 2014 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-25062696
11.
Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration.
Brain
; 136(Pt 7): 2130-46, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23757764
12.
Specific Detection of Physiological S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay.
J Parkinsons Dis
; 13(2): 255-270, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36847016
13.
Stereotaxic Intracranial Delivery of Chemicals, Proteins or Viral Vectors to Study Parkinson's Disease.
J Vis Exp
; (168)2021 02 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33682858
14.
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
EMBO Mol Med
; 13(9): e14745, 2021 09 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34309222
15.
LRRK2 mediates tubulation and vesicle sorting from lysosomes.
Sci Adv
; 6(46)2020 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33177079
16.
Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein.
Mol Neurodegener
; 15(1): 49, 2020 09 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32900375
17.
Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs.
Sci Rep
; 8(1): 15715, 2018 10 24.
Artigo
Inglês
| MEDLINE | ID: mdl-30356172
18.
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.
Mol Neurodegener
; 11(1): 61, 2016 08 22.
Artigo
Inglês
| MEDLINE | ID: mdl-27549140
19.
Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors.
PLoS One
; 8(5): e64844, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23705016
20.
Rapid, reproducible transduction of select forebrain regions by targeted recombinant virus injection into the neonatal mouse brain.
J Neurosci Methods
; 182(1): 55-63, 2009 Aug 30.
Artigo
Inglês
| MEDLINE | ID: mdl-19505498