RESUMO
Several cell lines that were derived from primates and inoculated with virus originally obtained from a spontaneous mammary carcinoma showed cytopathic effects characterized by multinucleation. These cytopathic effects appeared as early as 24 holurs after inoculation. Multinucleated cells contained virus particles characteristic of the original virus isolate.
Assuntos
Transformação Celular Neoplásica , Células Cultivadas , Vírus Oncogênicos/crescimento & desenvolvimento , Animais , Neoplasias da Mama/microbiologia , Carcinoma/microbiologia , Linhagem Celular , Núcleo Celular , Feto , Haplorrinos , Microscopia Eletrônica , Vírus Oncogênicos/isolamento & purificação , Coloração e RotulagemRESUMO
Rhesus monkeys neonatally inoculated with Mason-Pfizer monkey virus (M-PMV) and virus-infected cells frequently developed viral and/or bacterial pneumonia and enteritis. Three characteristic hematologic patterns occurred among the inoculated animals and correlated well with the probability of survival. Postmortem examination of the animals revealed lymphadenopathy and thymic atrophy. M-PMV was present in lymph nodes, blood, brain, spleen, thymus, kidneys, and bone marrow. The disease induced in some animals had characteristics suggestive of a slow-virus-induced autoimmune response.