Detalhe da pesquisa
1.
Precision proteoform design for 4R tau isoform selective templated aggregation.
Proc Natl Acad Sci U S A
; 121(15): e2320456121, 2024 Apr 09.
Artigo
Inglês
| MEDLINE | ID: mdl-38568974
2.
A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
J Biol Chem
; 300(4): 107163, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38484799
3.
Development of Receptor for Advanced Glycation End Products (RAGE) ligands through target directed dynamic combinatorial chemistry: a novel class of possible antagonists.
Chemistry
; 30(20): e202303255, 2024 Apr 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38317623
4.
Conformation and Affinity Modulations by Multiple Phosphorylation Occurring in the BIN1 SH3 Domain Binding Site of the Tau Protein Proline-Rich Region.
Biochemistry
; 62(11): 1631-1642, 2023 06 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37167199
5.
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.
Mol Ther
; 30(4): 1484-1499, 2022 04 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35007758
6.
NMR Spectroscopy of the Main Protease of SARS-CoV-2 and Fragment-Based Screening Identify Three Protein Hotspots and an Antiviral Fragment.
Angew Chem Int Ed Engl
; 60(48): 25428-25435, 2021 11 22.
Artigo
Inglês
| MEDLINE | ID: mdl-34570415
7.
Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.
J Am Chem Soc
; 142(27): 11772-11783, 2020 07 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32501683
8.
Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization.
Chemistry
; 26(31): 7131-7139, 2020 Jun 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32255539
9.
Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody.
Brain
; 142(6): 1736-1750, 2019 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31038156
10.
Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor.
Brain
; 142(11): 3636-3654, 2019 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31599329
11.
Identification of the Tau phosphorylation pattern that drives its aggregation.
Proc Natl Acad Sci U S A
; 114(34): 9080-9085, 2017 08 22.
Artigo
Inglês
| MEDLINE | ID: mdl-28784767
12.
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation.
Acta Neuropathol
; 138(4): 631-652, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31065832
13.
Nuclear Magnetic Resonance Spectroscopy Insights into Tau Structure in Solution: Impact of Post-translational Modifications.
Adv Exp Med Biol
; 1184: 35-45, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-32096026
14.
Zinc Binding to Tau Influences Aggregation Kinetics and Oligomer Distribution.
Int J Mol Sci
; 20(23)2019 Nov 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31783644
15.
NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.
J Biol Chem
; 292(44): 18024-18043, 2017 11 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28912275
16.
The O-ß-linked N-acetylglucosaminylation of the Lamin B receptor and its impact on DNA binding and phosphorylation.
Biochim Biophys Acta Gen Subj
; 1862(4): 825-835, 2018 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-29337275
17.
Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase.
J Biol Chem
; 291(14): 7742-53, 2016 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26858248
18.
Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25.
Nucleic Acids Res
; 43(14): 7110-21, 2015 Aug 18.
Artigo
Inglês
| MEDLINE | ID: mdl-26130716
19.
Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.
Proc Natl Acad Sci U S A
; 111(12): 4584-9, 2014 Mar 25.
Artigo
Inglês
| MEDLINE | ID: mdl-24623856
20.
A ß-Turn Motif in the Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52.
Biochemistry
; 55(38): 5366-76, 2016 09 27.
Artigo
Inglês
| MEDLINE | ID: mdl-27641460