Detalhe da pesquisa
1.
Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.
Nature
; 527(7577): 245-8, 2015 Nov 12.
Artigo
Inglês
| MEDLINE | ID: mdl-26536115
2.
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Bioorg Med Chem Lett
; 30(3): 126784, 2020 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31761656
3.
Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.
Bioorg Med Chem Lett
; 30(22): 127531, 2020 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32890685
4.
Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.
Nat Chem Biol
; 13(10): 1115-1122, 2017 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-28825711
5.
Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy.
Bioorg Med Chem Lett
; 29(3): 466-470, 2019 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30579797
6.
A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling.
Angew Chem Int Ed Engl
; 57(44): 14560-14565, 2018 10 26.
Artigo
Inglês
| MEDLINE | ID: mdl-30212610
7.
A Functional NaV1.7-NaVAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site.
Mol Pharmacol
; 92(3): 310-317, 2017 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28645932
8.
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect.
Nature
; 465(7294): 96-100, 2010 May 06.
Artigo
Inglês
| MEDLINE | ID: mdl-20410884
9.
Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action.
Proteins
; 83(2): 331-50, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25401969
10.
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Bioorg Med Chem Lett
; 25(9): 1856-63, 2015 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25845281
11.
Genotypic correlates of susceptibility to HIV-1 attachment inhibitor BMS-626529, the active agent of the prodrug BMS-663068.
J Antimicrob Chemother
; 69(3): 573-81, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24128669
12.
Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT6 antagonists.
Bioorg Med Chem
; 22(5): 1782-90, 2014 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24495863
13.
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Proc Natl Acad Sci U S A
; 108(37): 15366-71, 2011 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-21896751
14.
Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Nat Struct Mol Biol
; 31(2): 311-322, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38177675
15.
Oral estrogen receptor PROTAC® vepdegestrant (ARV-471) is highly efficacious as monotherapy and in combination with CDK4/6 or PI3K/mTOR pathway inhibitors in preclinical ER+ breast cancer models.
Clin Cancer Res
; 2024 May 31.
Artigo
Inglês
| MEDLINE | ID: mdl-38819400
16.
PROTAC targeted protein degraders: the past is prologue.
Nat Rev Drug Discov
; 21(3): 181-200, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35042991
17.
Mutagenic Activation of Glutathione Peroxidase-4: Approaches toward Rational Design of Allosteric Drugs.
ACS Omega
; 7(34): 29587-29597, 2022 Aug 30.
Artigo
Inglês
| MEDLINE | ID: mdl-36061715
18.
In vivo patterns of resistance to the HIV attachment inhibitor BMS-488043.
Antimicrob Agents Chemother
; 55(2): 729-37, 2011 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-21078948
19.
Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 7): 768-74, 2011 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21795790
20.
Communication: Quantum polarized fluctuating charge model: a practical method to include ligand polarizability in biomolecular simulations.
J Chem Phys
; 135(23): 231101, 2011 Dec 21.
Artigo
Inglês
| MEDLINE | ID: mdl-22191857