Detalhe da pesquisa
1.
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aß and tau.
Acta Neuropathol
; 147(1): 65, 2024 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38557897
2.
BiDiFuse: a FIJI plugin for fusing bi-directionally recorded microscopic image volumes.
Bioinformatics
; 32(23): 3691-3693, 2016 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27503222
3.
The Effects of Physiological and Methodological Determinants on 18F-FDG Mouse Brain Imaging Exemplified in a Double Transgenic Alzheimer Model.
Mol Imaging
; 152016.
Artigo
Inglês
| MEDLINE | ID: mdl-27030402
4.
Image Informatics Strategies for Deciphering Neuronal Network Connectivity.
Adv Anat Embryol Cell Biol
; 219: 123-48, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27207365
5.
Effect of stress and peripheral immune activation on astrocyte activation in transgenic bioluminescent Gfap-luc mice.
Glia
; 63(7): 1126-37, 2015 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-25690758
6.
The [18F]FDG µPET readout of a brain activation model to evaluate the metabotropic glutamate receptor 2 positive allosteric modulator JNJ-42153605.
J Pharmacol Exp Ther
; 350(2): 375-86, 2014 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-24898267
7.
Pharmacology of JNJ-42314415, a centrally active phosphodiesterase 10A (PDE10A) inhibitor: a comparison of PDE10A inhibitors with D2 receptor blockers as potential antipsychotic drugs.
J Pharmacol Exp Ther
; 349(1): 138-54, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24421319
8.
Differential interaction of neuroleptics with apomorphine-induced behavior in rats as a function of changing levels of dopamine receptor stimulation.
J Pharmacol Exp Ther
; 347(3): 681-96, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-24071734
9.
Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.
J Pharmacol Exp Ther
; 346(3): 514-27, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-23766542
10.
Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors.
Bioorg Med Chem Lett
; 23(3): 785-90, 2013 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23260348
11.
Systemic immune activation leads to neuroinflammation and sickness behavior in mice.
Mediators Inflamm
; 2013: 271359, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23935246
12.
Common mouse models of tauopathy reflect early but not late human disease.
Mol Neurodegener
; 18(1): 10, 2023 02 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36732784
13.
Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia.
J Pharmacol Exp Ther
; 342(1): 91-105, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22490380
14.
Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model.
iScience
; 25(1): 103658, 2022 Jan 21.
Artigo
Inglês
| MEDLINE | ID: mdl-35072001
15.
Patterns of brain glucose metabolism induced by phosphodiesterase 10A inhibitors in the mouse: a potential translational biomarker.
J Pharmacol Exp Ther
; 339(1): 210-7, 2011 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-21742809
16.
Molecular properties affecting fast dissociation from the D2 receptor.
Bioorg Med Chem
; 19(7): 2231-41, 2011 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21421319
17.
Adjunctive alpha2-adrenoceptor blockade enhances the antipsychotic-like effect of risperidone and facilitates cortical dopaminergic and glutamatergic, NMDA receptor-mediated transmission.
Int J Neuropsychopharmacol
; 13(7): 891-903, 2010 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-19835668
18.
Longitudinal Characterization of [18F]-FDG and [18F]-AV45 Uptake in the Double Transgenic TASTPM Mouse Model.
J Alzheimers Dis
; 55(4): 1537-1548, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-27911309
19.
Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission.
EJNMMI Radiopharm Chem
; 1(1): 3, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-29564380
20.
Evaluation of Small-Animal PET Outcome Measures to Detect Disease Modification Induced by BACE Inhibition in a Transgenic Mouse Model of Alzheimer Disease.
J Nucl Med
; 58(12): 1977-1983, 2017 12.
Artigo
Inglês
| MEDLINE | ID: mdl-28611242